Analyses of single-amino-acid substitution mutants of adenovirus type 5 E1B-55K protein
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Analysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery.The role of cullin 5-containing ubiquitin ligasesAdenovirus type 5 early region 1B 55K oncoprotein-dependent degradation of cellular factor Daxx is required for efficient transformation of primary rodent cellsDegradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complexThe Mre11 complex is required for ATM activation and the G2/M checkpointAdenovirus E1B 55-kilodalton protein is required for both regulation of mRNA export and efficient entry into the late phase of infection in normal human fibroblastsE4orf6 variants with separate abilities to augment adenovirus replication and direct nuclear localization of the E1B 55-kilodalton protein.Developing novel oncolytic adenoviruses through bioselectionComparative effect of oncolytic adenoviruses with E1A-55 kDa or E1B-55 kDa deletions in malignant gliomas2-aminopurine enhances the oncolytic activity of an E1b-deleted adenovirus in hepatocellular carcinoma cells.Effects of mutations in the adenoviral E1B 55-kilodalton protein coding sequence on viral late mRNA metabolism.Impact of the adenoviral E4 Orf3 protein on the activity and posttranslational modification of p53.Adenovirus replaces mitotic checkpoint controls.Adenovirus ubiquitin-protein ligase stimulates viral late mRNA nuclear export.Timely synthesis of the adenovirus type 5 E1B 55-kilodalton protein is required for efficient genome replication in normal human cells.The use of gene therapy in cancer research and treatment.The Role of Elongin BC-Containing Ubiquitin Ligases.Future directions and treatment strategies for head and neck squamous cell carcinomasViruses with deletions in antiapoptotic genes as potential oncolytic agents.Viruses - seeking and destroying the tumor program.The adenoviral E1B 55-kilodalton protein controls expression of immune response genes but not p53-dependent transcription.Adenovirus E1B 55-kilodalton protein: multiple roles in viral infection and cell transformation.Adenoviral vector-based strategies for cancer therapy.A proteomic approach to identify candidate substrates of human adenovirus E4orf6-E1B55K and other viral cullin-based E3 ubiquitin ligases.Adenovirus degradation of cellular proteins.Role of E1B55K in E4orf6/E1B55K E3 ligase complexes formed by different human adenovirus serotypes.Serotype-specific inactivation of the cellular DNA damage response during adenovirus infection.The E4orf6/E1B55K E3 ubiquitin ligase complexes of human adenoviruses exhibit heterogeneity in composition and substrate specificity.Infection with E1B-mutant adenovirus stabilizes p53 but blocks p53 acetylation and activity through E1A.Comparison of oncolytic adenoviruses for selective eradication of oral cancer and pre-cancerous lesions.Distinct requirements of adenovirus E1b55K protein for degradation of cellular substrates.Adenovirus E1B55K region is required to enhance cyclin E expression for efficient viral DNA replication.Normal human cell proteins that interact with the adenovirus type 5 E1B 55kDa protein.Mitochondrial localization of p53 during adenovirus infection and regulation of its activity by E1B-19K.E1B-55-kilodalton protein is not required to block p53-induced transcription during adenovirus infection.An armed oncolytic adenovirus system, ZD55-gene, demonstrating potent antitumoral efficacy.Adenovirus 2 E1B-55K protein relieves p53-mediated transcriptional repression of the survivin and MAP4 promoters.Characterization of the recombinant adenovirus vector AdYB-1: implications for oncolytic vector development.The adenovirus E1b55K/E4orf6 complex induces degradation of the Bloom helicase during infection.Telomerase-dependent oncolytic adenovirus for cancer treatment.
P2860
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P2860
Analyses of single-amino-acid substitution mutants of adenovirus type 5 E1B-55K protein
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Analyses of single-amino-acid substitution mutants of adenovirus type 5 E1B-55K protein
@en
Analyses of single-amino-acid substitution mutants of adenovirus type 5 E1B-55K protein.
@nl
type
label
Analyses of single-amino-acid substitution mutants of adenovirus type 5 E1B-55K protein
@en
Analyses of single-amino-acid substitution mutants of adenovirus type 5 E1B-55K protein.
@nl
prefLabel
Analyses of single-amino-acid substitution mutants of adenovirus type 5 E1B-55K protein
@en
Analyses of single-amino-acid substitution mutants of adenovirus type 5 E1B-55K protein.
@nl
P2093
P2860
P1433
P1476
Analyses of single-amino-acid substitution mutants of adenovirus type 5 E1B-55K protein
@en
P2093
P2860
P304
P356
10.1128/JVI.75.9.4297-4307.2001
P407
P577
2001-05-01T00:00:00Z