Three-dimensional collagen I promotes gemcitabine resistance in pancreatic cancer through MT1-MMP-mediated expression of HMGA2. - Wikidata - awgldk - TriplyDB

Three-dimensional collagen I promotes gemcitabine resistance in pancreatic cancer through MT1-MMP-mediated expression of HMGA2.

Three-dimensional collagen I promotes gemcitabine resistance in pancreatic cancer through MT1-MMP-mediated expression of HMGA2.

http://www.wikidata.org/entity/Q39621410

about

Emerging concepts in pancreatic cancer medicine: targeting the tumor stroma Biomarkers and Targeted Therapy in Pancreatic Cancer Orchestrating the Tumor Microenvironment to Improve Survival for Patients With Pancreatic Cancer: Normalization, Not Destruction Moving targets: Emerging roles for MMPs in cancer progression and metastasis Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma A bioengineered heterotypic stroma-cancer microenvironment model to study pancreatic ductal adenocarcinoma.Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.Recent treatment advances and novel therapies in pancreas cancer: a review.Influence of the microenvironment on cell fate determination and migration Thiol-ene hydrogels as desmoplasia-mimetic matrices for modeling pancreatic cancer cell growth, invasion, and drug resistance.Three-dimensional collagen I promotes gemcitabine resistance in vitro in pancreatic cancer cells through HMGA2-dependent histone acetyltransferase expression.Contribution of epithelial-to-mesenchymal transition and cancer stem cells to pancreatic cancer progression Interplay between β1-integrin and Rho signaling regulates differential scattering and motility of pancreatic cancer cells by snail and Slug proteins.Inactivation of Ink4a/Arf leads to deregulated expression of miRNAs in K-Ras transgenic mouse model of pancreatic cancer.Magnetization transfer MRI in pancreatic cancer xenograft models.Targeting the cancer-stroma interaction: a potential approach for pancreatic cancer treatment Validation of Polo-like kinase 1 as a therapeutic target in pancreatic cancer cells Cancer Cell Invasion in Three-dimensional Collagen Is Regulated Differentially by Gα13 Protein and Discoidin Domain Receptor 1-Par3 Protein Signaling Inhibition of endotrophin, a cleavage product of collagen VI, confers cisplatin sensitivity to tumours.Collecting duct carcinoma of the kidney is associated with CDKN2A deletion and SLC family gene up-regulation.Quantitative magnetization transfer MRI of desmoplasia in pancreatic ductal adenocarcinoma xenografts.A furin inhibitor downregulates osteosarcoma cell migration by downregulating the expression levels of MT1-MMP via the Wnt signaling pathway.Biochemical role of the collagen-rich tumour microenvironment in pancreatic cancer progression.FOLFIRINOX - a new paradigm in the treatment of pancreatic cancer.Ethanol differentially regulates snail family of transcription factors and invasion of premalignant and malignant pancreatic ductal cells.Targeting the microenvironment of pancreatic cancer: overcoming treatment barriers and improving local immune responses.Stroma-regulated HMGA2 is an independent prognostic marker in PDAC and AAC.Circulating high mobility group AT-hook 2 and pleomorphic adenoma gene 1 in blood of patients with oral squamous cell carcinoma.Anti-stromal treatment together with chemotherapy targets multiple signalling pathways in pancreatic adenocarcinoma GLI2-dependent c-MYC upregulation mediates resistance of pancreatic cancer cells to the BET bromodomain inhibitor JQ1.Neutralizing murine TGFβR2 promotes a differentiated tumor cell phenotype and inhibits pancreatic cancer metastasis.Snail cooperates with Kras G12D in vivo to increase stem cell factor and enhance mast cell infiltration.3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing.Biology of pancreatic stellate cells-more than just pancreatic cancer.Mapping lung tumor cell drug responses as a function of matrix context and genotype using cell microarrays.The non-receptor tyrosine kinase c-Src mediates the PDGF-induced association between Furin and pro-MT1-MMP in HPAC pancreatic cells.HMGA2 induces epithelial-to-mesenchymal transition in human hepatocellular carcinoma cells.Multicellular tumor spheroid model to evaluate spatio-temporal dynamics effect of chemotherapeutics: application to the gemcitabine/CHK1 inhibitor combination in pancreatic cancer Snail cooperates with KrasG12D to promote pancreatic fibrosis Collagen gel protects L929 cells from TNFα-induced death by activating NF-κB.

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P2860

Three-dimensional collagen I promotes gemcitabine resistance in pancreatic cancer through MT1-MMP-mediated expression of HMGA2.

http://www.wikidata.org/entity/Q39621410

description

2010 nî lūn-bûn

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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2010年论文

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2010年论文

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name

Three-dimensional collagen I p ...... -mediated expression of HMGA2.

@en

Three-dimensional collagen I p ...... -mediated expression of HMGA2.

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type

label

Three-dimensional collagen I p ...... -mediated expression of HMGA2.

@en

Three-dimensional collagen I p ...... -mediated expression of HMGA2.

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prefLabel

Three-dimensional collagen I p ...... -mediated expression of HMGA2.

@en

Three-dimensional collagen I p ...... -mediated expression of HMGA2.

@nl

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0008-5472.CAN-10-1855

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Cancer Research

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Three-dimensional collagen I p ...... -mediated expression of HMGA2.

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David J Bentrem

http://www.w3.org/2001/XMLSchema#string

Hidayatullah G Munshi

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Mario A Shields

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Michael J Heiferman

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Morgan R Barron

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Paul J Grippo

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Seth B Krantz

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Surabhi Dangi-Garimella

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P2860

High mobility group A2 protein and its derivatives bind a specific region of the promoter of DNA repair gene ERCC1 and modulate its activity

Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2

High mobility group A2 potentiates genotoxic stress in part through the modulation of basal and DNA damage-dependent phosphatidylinositol 3-kinase-related protein kinase activation

HMGA2 exhibits dRP/AP site cleavage activity and protects cancer cells from DNA-damage-induced cytotoxicity during chemotherapy

Suppression of nonhomologous end joining repair by overexpression of HMGA2

Collagen regulation of let-7 in pancreatic cancer involves TGF-β1-mediated membrane type 1-matrix metalloproteinase expression

Gemcitabine-based chemogene therapy for pancreatic cancer using Ad-dCK::UMK GDEPT and TS/RR siRNA strategies

Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7

Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation

The tumor suppressor microRNA let-7 represses the HMGA2 oncogene.

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1019-1028

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10.1158/0008-5472.CAN-10-1855

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3

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71

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2010-12-08T00:00:00Z

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21148071

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3076124

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