beta-TrCP-mediated ubiquitination and degradation of PHLPP1 are negatively regulated by Akt.
about
The CK1 Family: Contribution to Cellular Stress Response and Its Role in CarcinogenesisPHLPP-mediated dephosphorylation of S6K1 inhibits protein translation and cell growthThe de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signalingCullin-RING ligases in regulation of autophagyNuclear PI3K signaling in cell growth and tumorigenesisTurning off AKT: PHLPP as a drug targetMaximising the potential of AKT inhibitors as anti-cancer treatmentsWD repeat protein WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1)Suppression of survival signalling pathways by the phosphatase PHLPPThe pursuit of oncotargets through understanding defective cell regulationSAG/RBX2 E3 ligase complexes with UBCH10 and UBE2S E2s to ubiquitylate β-TrCP1 via K11-linkage for degradationDiscovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening.The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs.SCFβ-TRCP regulates osteoclastogenesis via promoting CYLD ubiquitination.Cullins and cancer.mTOR-dependent regulation of PHLPP expression controls the rapamycin sensitivity in cancer cells.Contactin-1 reduces E-cadherin expression via activating AKT in lung cancer.Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt.AP-1 regulates cyclin D1 and c-MYC transcription in an AKT-dependent manner in response to mTOR inhibition: role of AIP4/Itch-mediated JUNB degradationPleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP): a new player in cell signaling.Targeting the mTOR-DEPTOR pathway by CRL E3 ubiquitin ligases: therapeutic applicationS6 Kinase- and β-TrCP2-Dependent Degradation of p19Arf Is Required for Cell ProliferationmTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2.Greatwall promotes cell transformation by hyperactivating AKT in human malignancies.Diacylglycerol kinase δ modulates Akt phosphorylation through pleckstrin homology domain leucine-rich repeat protein phosphatase 2 (PHLPP2)Downregulation of vascular endothelial growth factor receptor-2 under oxidative stress conditions is mediated by β-transduction repeat-containing protein via glycogen synthase kinase-3β signalingNeddylation inhibitor MLN4924 suppresses growth and migration of human gastric cancer cells.Protein phosphatase PPM1G regulates protein translation and cell growth by dephosphorylating 4E binding protein 1 (4E-BP1)Pharmacological inhibition of pleckstrin homology domain leucine-rich repeat protein phosphatase is neuroprotective: differential effects on astrocytesBerberine Suppresses Cyclin D1 Expression through Proteasomal Degradation in Human Hepatoma Cells.Depletion of SAG/RBX2 E3 ubiquitin ligase suppresses prostate tumorigenesis via inactivation of the PI3K/AKT/mTOR axis.A GNAS mutation found in pancreatic intraductal papillary mucinous neoplasms induces drastic alterations of gene expression profiles with upregulation of mucin genes.Nutrient-induced FNIP degradation by SCFβ-TRCP regulates FLCN complex localization and promotes renal cancer progressionAKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis.Therapeutic targeting of the phosphatidylinositol 3-kinase signaling pathway: novel targeted therapies and advances in the treatment of colorectal cancer.The role of ubiquitin-proteasome system in glioma survival and growth.PHLPP phosphatases as a therapeutic target in insulin resistance-related diseases.USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKT signaling.Deubiquitinating enzyme Usp12 regulates the interaction between the androgen receptor and the Akt pathway.PHLPPing through history: a decade in the life of PHLPP phosphatases.
P2860
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P2860
beta-TrCP-mediated ubiquitination and degradation of PHLPP1 are negatively regulated by Akt.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
beta-TrCP-mediated ubiquitinat ...... e negatively regulated by Akt.
@en
beta-TrCP-mediated ubiquitinat ...... e negatively regulated by Akt.
@nl
type
label
beta-TrCP-mediated ubiquitinat ...... e negatively regulated by Akt.
@en
beta-TrCP-mediated ubiquitinat ...... e negatively regulated by Akt.
@nl
prefLabel
beta-TrCP-mediated ubiquitinat ...... e negatively regulated by Akt.
@en
beta-TrCP-mediated ubiquitinat ...... e negatively regulated by Akt.
@nl
P2093
P2860
P356
P1476
beta-TrCP-mediated ubiquitinat ...... e negatively regulated by Akt.
@en
P2093
P2860
P304
P356
10.1128/MCB.00681-09
P407
P577
2009-09-21T00:00:00Z