Werner syndrome protein limits MYC-induced cellular senescence. - Wikidata - awgldk - TriplyDB

Werner syndrome protein limits MYC-induced cellular senescence.

Werner syndrome protein limits MYC-induced cellular senescence.

http://www.wikidata.org/entity/Q39895677

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The effect of eukaryotic release factor depletion on translation termination in human cell lines N-methyl-N'-nitro-N-nitrosoguanidine-induced senescence-like growth arrest in colon cancer cells is associated with loss of adenomatous polyposis coli protein, microtubule organization, and telomeric DNA Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex Human premature aging, DNA repair and RecQ helicases MYC activation is a hallmark of cancer initiation and maintenance c-Myc accelerates S-phase and requires WRN to avoid replication stress A human T-cell lymphotropic virus type 1 enhancer of Myc transforming potential stabilizes Myc-TIP60 transcriptional interactions The Werner syndrome exonuclease facilitates DNA degradation and high fidelity DNA polymerization by human DNA polymerase δ Quantitative proteomic analysis of myc-induced apoptosis: a direct role for Myc induction of the mitochondrial chloride ion channel, mtCLIC/CLIC4 Sp1 is essential for p16 expression in human diploid fibroblasts during senescence.Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation.The Werner syndrome protein suppresses telomeric instability caused by chromium (VI) induced DNA replication stress.MYC and the control of DNA replication.Inactivation of MYC reverses tumorigenesis.The transcriptional repressor dMnt is a regulator of growth in Drosophila melanogaster Acrolein-exposed normal human lung fibroblasts in vitro: cellular senescence, enhanced telomere erosion, and degradation of Werner's syndrome protein Stable cellular senescence is associated with persistent DDR activation Monogenic syndromes of abnormal glucose homeostasis: clinical review and relevance to the understanding of the pathology of insulin resistance and beta cell failure.Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a).Viral-mediated noisy gene expression reveals biphasic E2f1 response to MYC Myc influences global chromatin structure.The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds.PP2A-B56α controls oncogene-induced senescence in normal and tumor human melanocytic cells MYC is a critical target of FBXW7 Discovering new medicines targeting helicases: challenges and recent progress.Novel ARF/p53-independent senescence pathways in cancer repression."...Rewritten in the skin": clues to skin biology and aging from inherited disease.Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation Epigallocatechin-3-gallate decreases UVA-induced HPRT mutations in human skin fibroblasts accompanied by increased rates of senescence and apoptosis.Depletion of WRN enhances DNA damage in HeLa cells exposed to the benzene metabolite, hydroquinone.Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability Unique and important consequences of RECQ1 deficiency in mammalian cells.RNAi screening uncovers Dhx9 as a modifier of ABT-737 resistance in an Eμ-myc/Bcl-2 mouse model.Helicases as prospective targets for anti-cancer therapy.Camptothecin targets WRN protein: mechanism and relevance in clinical breast cancer.Werner syndrome protein, WRN, protects cells from DNA damage induced by the benzene metabolite hydroquinone Fibroblasts from Werner syndrome patients: cancer cells derived by experimental introduction of oncogenes maintain malignant properties despite entering crisis.Cdc45 is a critical effector of myc-dependent DNA replication stress.The regulatory role of c-MYC on HDAC2 and PcG expression in human multipotent stem cells.

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P2860

Werner syndrome protein limits MYC-induced cellular senescence.

http://www.wikidata.org/entity/Q39895677

description

2003 nî lūn-bûn

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2003年の論文

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年學術文章

@yue

2003年學術文章

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2003年學術文章

@zh-hant

name

Werner syndrome protein limits MYC-induced cellular senescence.

@en

Werner syndrome protein limits MYC-induced cellular senescence.

@nl

type

label

Werner syndrome protein limits MYC-induced cellular senescence.

@en

Werner syndrome protein limits MYC-induced cellular senescence.

@nl

prefLabel

Werner syndrome protein limits MYC-induced cellular senescence.

@en

Werner syndrome protein limits MYC-induced cellular senescence.

@nl

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Genes & Development

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Werner syndrome protein limits MYC-induced cellular senescence.

@en

P2093

Bruce E Clurman

http://www.w3.org/2001/XMLSchema#string

Carla Grandori

http://www.w3.org/2001/XMLSchema#string

Celine Ngouenet

http://www.w3.org/2001/XMLSchema#string

David W Russell

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Jonathan Grim

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Junko Oshima

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Karen Swisshelm

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Kou-Juey Wu

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Michael J Moser

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Raymond J Monnat

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P2860

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

A system for stable expression of short interfering RNAs in mammalian cells

The Myc/Max/Mad network and the transcriptional control of cell behavior

Excess of rare cancers in Werner syndrome (adult progeria)

Myc activates telomerase

Mutations in the WRN gene in mice accelerate mortality in a p53-null background

A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

Induction of apoptosis in fibroblasts by c-myc protein

Improved retroviral vectors for gene transfer and expression.

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1569-1574

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10.1101/GAD.1100303

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13

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17

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Paula Fernandez

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2003-07-01T00:00:00Z

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10676644

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12842909

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196129

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