Truncation of titin's elastic PEVK region leads to cardiomyopathy with diastolic dysfunction. - Wikidata - awgldk - TriplyDB

Truncation of titin's elastic PEVK region leads to cardiomyopathy with diastolic dysfunction.

Truncation of titin's elastic PEVK region leads to cardiomyopathy with diastolic dysfunction.

http://www.wikidata.org/entity/Q39955523

about

Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease Titin-based tension in the cardiac sarcomere: molecular origin and physiological adaptations Pathophysiological defects and transcriptional profiling in the RBM20-/- rat model What global diastolic function is, what it is not, and how to measure it Titin-isoform dependence of titin-actin interaction and its regulation by S100A1/Ca2+ in skinned myocardium Genetic epidemiology of titin-truncating variants in the etiology of dilated cardiomyopathy.Hypertrophic cardiomyopathy and sudden cardiac death Experimentally increasing titin compliance in a novel mouse model attenuates the Frank-Starling mechanism but has a beneficial effect on diastole.Transcriptional regulation and alternative splicing cooperate in muscle fiber-type specification in flies and mammals.Excision of titin's cardiac PEVK spring element abolishes PKCalpha-induced increases in myocardial stiffness Physiologic basis and pathophysiologic implications of the diastolic properties of the cardiac muscle Genetics of mechanosensation in the heart.Deleting titin's I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function.Titin-based mechanosensing and signaling: role in diaphragm atrophy during unloading?Increased myocardial stiffness due to cardiac titin isoform switching in a mouse model of volume overload limits eccentric remodeling Titin based viscosity in ventricular physiology: an integrative investigation of PEVK-actin interactions.Titin visualization in real time reveals an unexpected level of mobility within and between sarcomeres Hyperphosphorylation of mouse cardiac titin contributes to transverse aortic constriction-induced diastolic dysfunction Titin-actin interaction: PEVK-actin-based viscosity in a large animal Investigation of Pathogenic Genes in Chinese sporadic Hypertrophic Cardiomyopathy Patients by Whole Exome Sequencing Conformational dynamics of titin PEVK explored with FRET spectroscopy.The multifunctional Ca(2+)/calmodulin-dependent protein kinase II delta (CaMKIIδ) phosphorylates cardiac titin's spring elements.Shortening of the elastic tandem immunoglobulin segment of titin leads to diastolic dysfunction.Inhibition of DNA methylation reverses norepinephrine-induced cardiac hypertrophy in rats.Removal of immunoglobulin-like domains from titin's spring segment alters titin splicing in mouse skeletal muscle and causes myopathy.Cardiac titin: a multifunctional giant Conformation-regulated mechanosensory control via titin domains in cardiac muscle.The genetic landscape of cardiomyopathy and its role in heart failure.Animal Models of Congenital Cardiomyopathies Associated With Mutations in Z-Line Proteins.Interspecies differences in virus uptake versus cardiac function of the coxsackievirus and adenovirus receptor.Overview of the Muscle Cytoskeleton.Alternative Splicing of Titin Restores Diastolic Function in an HFpEF-Like Genetic Murine Model (TtnΔIAjxn)The effects of PKCalpha phosphorylation on the extensibility of titin's PEVK element.Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy.Experimentally Increasing the Compliance of Titin Through RNA Binding Motif-20 (RBM20) Inhibition Improves Diastolic Function In a Mouse Model of Heart Failure With Preserved Ejection Fraction.Mechanical responses of the mechanosensitive unstructured domains in cardiac titin.Dilated Cardiomyopathy: Genetic Determinants and Mechanisms.Exploiting the CRISPR/Cas9 system to study alternative splicing in vivo: application to titin.Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling.

P2860

Q24608485-F5C01ADD-32BF-4117-B046-FCC6CD18A021 Q26996063-85109846-8AAD-4EE3-B1C8-7F2519F2718E Q27335405-E610FCEC-D306-4EB3-AF7C-0AD87ECC9573 Q28087043-FB179CD1-AC3C-4E96-8B28-77E3AB3E9C94 Q28280473-1A9837F8-13F1-448B-9201-D378DB618DB1 Q30234440-2B78DB33-0A46-441B-AC54-94A86C14E3D1 Q30433865-0F54DCD8-FB55-4FCB-88B5-7200FE8E797D Q33654696-2F003A40-B7B7-453F-B2A3-8E4876FFC61D Q33693614-DDDBE51B-E025-4BDD-8F4B-D788137D4B5E Q33787977-8DFA6631-B4DA-4576-B31C-8C565E259674 Q33961078-40C86A0D-92A4-497E-BC8C-F0A76613B508 Q34167579-DA2649F1-E972-481E-9570-396742294941 Q34407578-F2207992-5495-4F38-95AC-65E8C2C74D93 Q34598730-5A385C3E-C429-43B6-8FD2-6AAA567B144B Q34995889-82915993-1F65-424C-BBD8-F9EC3C3132AC Q35147808-FE470236-67E0-44DB-A7BB-DF8D5E9CCAA3 Q35196059-8A94C213-77DA-4E0A-B29C-32A754EFF9AC Q35316187-649ED9D8-A2E9-4707-95B9-70336EBEAD8E Q35582401-2A223161-A934-49AE-8C71-BC42352A6ABF Q36287303-0D48DBB5-C9E8-4E80-BE45-5FB121431AB8 Q36317978-BE2EF8C7-AD78-4D05-8B83-3B31D70A5BC4 Q36504127-172A4AAF-0106-479C-A3A4-F8291D46273E Q37292468-3AD40ED5-B4F4-4B97-BA40-07375F2795BD Q37591215-ACF1B00E-CFC9-4342-9444-4DEFD4E5F41C Q37727056-226906EB-3847-4B82-A819-410D2BB75E1C Q37755897-BB2A2107-BA55-433B-8C8A-BF2781A6EDDB Q37846578-DE5CDDAE-C38E-4582-9F11-CEE82D5ECA07 Q38343935-DA6542B8-DE44-4454-8C6D-2C6CB6ABBA2D Q38832827-C860DE3B-5794-4C4A-9FB1-392777806955 Q39208267-14C0188C-CA38-4B91-B576-8D4D7130B21B Q39391006-A7624973-95C5-49D3-81C8-E9AE288FB590 Q39547806-36477782-CA70-4487-BD4C-A7338EA775EC Q40094035-DCC30C2F-3ED5-4D51-98D8-2833C1C193E5 Q42356685-4EB2B51F-B0CC-4698-8B06-CBBC96986CB5 Q42382004-CCB7A3BC-42D9-426C-A857-28B9C20523CD Q47308838-21A810F8-F1A9-42FA-9EAA-22077002570A Q50083275-765D7985-2A3B-40E4-A9F2-2575CCE73BCF Q51148325-98920D02-1941-4AC3-935C-FF7795C92BAB Q55437377-FEC4BC82-FD23-4552-A62C-9765D126CDCE

P2860

Truncation of titin's elastic PEVK region leads to cardiomyopathy with diastolic dysfunction.

http://www.wikidata.org/entity/Q39955523

description

2009 nî lūn-bûn

@nan

2009年の論文

@ja

2009年学术文章

@wuu

2009年学术文章

@zh-cn

2009年学术文章

@zh-hans

2009年学术文章

@zh-my

2009年学术文章

@zh-sg

2009年學術文章

@yue

2009年學術文章

@zh

2009年學術文章

@zh-hant

name

Truncation of titin's elastic ...... hy with diastolic dysfunction.

@en

Truncation of titin's elastic ...... hy with diastolic dysfunction.

@nl

type

label

Truncation of titin's elastic ...... hy with diastolic dysfunction.

@en

Truncation of titin's elastic ...... hy with diastolic dysfunction.

@nl

prefLabel

Truncation of titin's elastic ...... hy with diastolic dysfunction.

@en

Truncation of titin's elastic ...... hy with diastolic dysfunction.

@nl

P1433

Q39955523-BBEF22A0-B3DD-4246-8A7D-100DC834E168

P1476

Q39955523-7EC67661-CCAD-4FAD-A79B-8FCE41C0CE96

P2093

Q39955523-0B0E5644-B5F4-4099-B649-900888A6EFD7

Q39955523-0E88F544-C6C6-4641-A001-36C56C94866B

Q39955523-168951F9-405C-4F6F-AFA2-931A95AAA3DA

Q39955523-1E5B4B41-D8AF-4200-B89F-A64F2FAEEE2A

Q39955523-3BCD7E1E-892F-4FE3-A8BD-653595845F00

Q39955523-43D6A5F7-6A2C-4582-B15F-9BA0E292FB0D

Q39955523-654F8707-6C74-466E-8337-082AA47188AD

Q39955523-81824253-9B42-41F4-97AE-452469BDF44C

Q39955523-9C2C851F-31CC-4002-B912-56D543587E44

Q39955523-9F532077-6D2A-46FE-B30F-6EFF2F031DDB

P2860

Q39955523-054130CE-7E9F-45A6-8C15-E69A2B84E4C9

Q39955523-06AA6C92-3B71-4DBD-B0AF-8BDDFD78CACB

Q39955523-0BDC36B5-B78D-401B-93EC-43AF9942969A

Q39955523-16F93420-E90F-4182-B1FF-603AC62BE3D4

Q39955523-1CF019EF-5899-4467-9C33-AEC566C93577

Q39955523-229B2A07-657C-4831-A976-1A94870CEFA7

Q39955523-2B83ECF1-D512-457C-A50B-815FFE5BD330

Q39955523-33823D58-B657-4C69-891F-D02B41302BAF

Q39955523-36D80A5F-E738-42CE-A474-1F67F81F4128

Q39955523-3FC5024F-C299-4575-86C5-6BE2C97E8BEB

P304

Q39955523-2698A237-B51B-411C-9C89-157EC36B0343

P31

Q39955523-4C487A32-1569-445B-9B27-DE8F7A0E4F0D

P356

Q39955523-B715B656-B405-4D43-A0C3-ADB9503CE755

P433

Q39955523-4B8F3571-DE54-474A-B3C9-108EFA3568D0

P478

Q39955523-27A6CA9D-5186-434C-9856-308818109552

P50

Q39955523-940B8B83-0A03-4B61-9FB7-045991E55FE8

Q39955523-B600D3AA-43DB-43AD-AB79-3C26328F715B

P577

Q39955523-05582D2E-AA8F-492B-9EAC-50D1DD2A0FC0

P698

Q39955523-694C2EA0-0B7B-44AB-9881-0EE9C7899A54

P921

Q39955523-9391611E-4B64-449A-A5E6-824DB4414FB5

P932

Q39955523-2BB814FC-D71B-408C-8A71-DCB931688980

P356

CIRCRESAHA.109.200964

P1433

Circulation Research

P1476

Truncation of titin's elastic ...... hy with diastolic dysfunction.

@en

P2093

Carsten Tschöpe

http://www.w3.org/2001/XMLSchema#string

Dirk Westermann

http://www.w3.org/2001/XMLSchema#string

Douglas F Larson

http://www.w3.org/2001/XMLSchema#string

Henk L Granzier

http://www.w3.org/2001/XMLSchema#string

Jun Peng

http://www.w3.org/2001/XMLSchema#string

Katharina Rost

http://www.w3.org/2001/XMLSchema#string

Mark McNabb

http://www.w3.org/2001/XMLSchema#string

Nicholas M P King

http://www.w3.org/2001/XMLSchema#string

O Lynne Nelson

http://www.w3.org/2001/XMLSchema#string

Qianli Yu

http://www.w3.org/2001/XMLSchema#string

P2860

Titins: giant proteins in charge of muscle ultrastructure and elasticity

Titin-actin interaction in mouse myocardium: passive tension modulation and its regulation by calcium/S100A1

Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2

Ischemia-induced association of the stress protein alpha B-crystallin with I-band portion of cardiac titin

Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy

M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere

High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP

Molecular dissection of N2B cardiac titin's extensibility

The giant protein titin: a major player in myocardial mechanics, signaling, and disease.

An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice

P304

557-564

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1161/CIRCRESAHA.109.200964

http://www.w3.org/2001/XMLSchema#string

P433

6

http://www.w3.org/2001/XMLSchema#string

P478

105

http://www.w3.org/2001/XMLSchema#string

P50

Michael Gotthardt

Michael H Radke

P577

2009-08-13T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

19679835

http://www.w3.org/2001/XMLSchema#string

P921

P932

2785004

http://www.w3.org/2001/XMLSchema#string