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Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of LckBruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding proteinEtk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation.Interaction of Bruton's tyrosine kinase and protein kinase Ctheta in platelets. Cross-talk between tyrosine and serine/threonine kinasesRegulation of nuclear localization and transcriptional activity of TFII-I by Bruton's tyrosine kinaseThe Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancyIdentification of the binding site for Gqalpha on its effector Bruton's tyrosine kinaseNeuropeptide-induced androgen independence in prostate cancer cells: roles of nonreceptor tyrosine kinases Etk/Bmx, Src, and focal adhesion kinaseCrystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobulinemiaInteraction of SLP adaptors with the SH2 domain of Tec family kinasesLck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activityThe role of Tec protein-tyrosine kinase in T cell signalingRegulation of nucleocytoplasmic shuttling of Bruton's tyrosine kinase (Btk) through a novel SH3-dependent interaction with ankyrin repeat domain 54 (ANKRD54).Expression of kinase-defective mutants of c-Src in human metastatic colon cancer cells decreases Bcl-xL and increases oxaliplatin- and Fas-induced apoptosis.Itk phosphorylation sites are required for functional activity in primary T cells.Interaction between Btk TH and SH3 domain.Nucleocytoplasmic shuttling of Bruton's tyrosine kinase.A phosphorylation site in Bruton's tyrosine kinase selectively regulates B cell calcium signaling efficiency by altering phospholipase C-gamma activation.Bruton's tyrosine kinase regulates immunoglobulin promoter activation in association with the transcription factor Bright.Phosphatidylinositol 3-kinase-gamma activates Bruton's tyrosine kinase in concert with Src family kinases.Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation.Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies.The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species.Bruton's tyrosine kinase: cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling.Tyrosine kinase BMX phosphorylates phosphotyrosine-primed motif mediating the activation of multiple receptor tyrosine kinasesA novel role for Bruton's tyrosine kinase in hepatocyte growth factor-mediated immunoregulation of dendritic cells.A role for the Tec family tyrosine kinase Txk in T cell activation and thymocyte selectionPhosphatidylinositol 3,4,5-trisphosphate regulates Ca(2+) entry via btk in platelets and megakaryocytes without increasing phospholipase C activity.Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways.Phosphorylation of two regulatory tyrosine residues in the activation of Bruton's tyrosine kinase via alternative receptors.Btk dosage determines sensitivity to B cell antigen receptor cross-linkingIbrutinib: an evidence-based review of its potential in the treatment of advanced chronic lymphocytic leukemia.The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile InflammationConformational snapshots of Tec kinases during signaling.PCI-32765: a novel Bruton's tyrosine kinase inhibitor for the treatment of lymphoid malignancies.Bruton tyrosine kinase (BTK) and its role in B-cell malignancy.Tyrosine kinase inhibitors as potential drugs for B-cell lymphoid malignancies and autoimmune disorders.BCR signaling in chronic lymphocytic leukemia and related inhibitors currently in clinical studies.Signaling pathways in lymphoma: pathogenesis and therapeutic targets.Lipid and Protein Co-Regulation of PI3K Effectors Akt and Itk in Lymphocytes.
P2860
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P2860
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Regulation of Btk by Src family tyrosine kinases.
@en
type
label
Regulation of Btk by Src family tyrosine kinases.
@en
prefLabel
Regulation of Btk by Src family tyrosine kinases.
@en
P2093
P2860
P356
P1476
Regulation of Btk by Src family tyrosine kinases.
@en
P2093
P2860
P304
P356
10.1128/MCB.16.7.3465
P407
P577
1996-07-01T00:00:00Z