The 86-kilodalton IE-2 protein of human cytomegalovirus is a sequence-specific DNA-binding protein that interacts directly with the negative autoregulatory response element located near the cap site of the IE-1/2 enhancer-promoter.
about
Functional interaction between pleiotropic transactivator pUL69 of human cytomegalovirus and the human homolog of yeast chromatin regulatory protein SPT6Proteasome-independent disruption of PML oncogenic domains (PODs), but not covalent modification by SUMO-1, is required for human cytomegalovirus immediate-early protein IE1 to inhibit PML-mediated transcriptional repression.RNA-binding of the human cytomegalovirus transactivator protein UL69, mediated by arginine-rich motifs, is not required for nuclear export of unspliced RNA.Open reading frame UL26 of human cytomegalovirus encodes a novel tegument protein that contains a strong transcriptional activation domain.Human cytomegalovirus and human herpesvirus 6 genes that transform and transactivateDisruption of PML subnuclear domains by the acidic IE1 protein of human cytomegalovirus is mediated through interaction with PML and may modulate a RING finger-dependent cryptic transactivator function of PMLTranscription factor Sp1 mediates cell-specific trans-activation of the human cytomegalovirus DNA polymerase gene promoter by immediate-early protein IE86 in glioblastoma U373MG cells.Defective growth correlates with reduced accumulation of a viral DNA replication protein after low-multiplicity infection by a human cytomegalovirus ie1 mutant.Covalent modification of the transactivator protein IE2-p86 of human cytomegalovirus by conjugation to the ubiquitin-homologous proteins SUMO-1 and hSMT3b.Identification of a boundary domain adjacent to the potent human cytomegalovirus enhancer that represses transcription of the divergent UL127 promoter.The major immediate-early gene ie3 of mouse cytomegalovirus is essential for viral growth.Glucocorticosteroids trigger reactivation of human cytomegalovirus from latently infected myeloid cells and increase the risk for HCMV infection in D+R+ liver transplant patients.Absence of IE1 p72 protein function during low-multiplicity infection by human cytomegalovirus results in a broad block to viral delayed-early gene expression.The IE2 60-kilodalton and 40-kilodalton proteins are dispensable for human cytomegalovirus replication but are required for efficient delayed early and late gene expression and production of infectious virus.Isolation and characterization of a low-abundance splice variant from the human cytomegalovirus major immediate-early gene region.Human cytomegalovirus upregulates NF-kappa B activity by transactivating the NF-kappa B p105/p50 and p65 promoters.The autoregulatory and transactivating functions of the human cytomegalovirus IE86 protein use independent mechanisms for promoter binding.Cellular or viral protein binding to a cytomegalovirus promoter transcription initiation site: effects on transcription.The IE2 regulatory protein of human cytomegalovirus induces expression of the human transforming growth factor beta1 gene through an Egr-1 binding site.The human cytomegalovirus UL37 immediate-early regulatory protein is an integral membrane N-glycoprotein which traffics through the endoplasmic reticulum and Golgi apparatusThe human cytomegalovirus IE1-72 protein interacts with the cellular p107 protein and relieves p107-mediated transcriptional repression of an E2F-responsive promoter.Synergistic interactions between overlapping binding sites for the serum response factor and ELK-1 proteins mediate both basal enhancement and phorbol ester responsiveness of primate cytomegalovirus major immediate-early promoters in monocyte and T-The major immediate-early proteins IE1 and IE2 of human cytomegalovirus colocalize with and disrupt PML-associated nuclear bodies at very early times in infected permissive cells.The human cytomegalovirus 86-kilodalton immediate-early 2 protein: synthesis as a precursor polypeptide and interaction with a 75-kilodalton protein of probable viral origin.Protein-protein interactions between human cytomegalovirus IE2-580aa and pUL84 in lytically infected cells.Human cytomegalovirus immediate-early gene 2 protein interacts with itself and with several novel cellular proteinsIdentification and mapping of dimerization and DNA-binding domains in the C terminus of the IE2 regulatory protein of human cytomegalovirus.Dynamic histone H3 acetylation and methylation at human cytomegalovirus promoters during replication in fibroblasts.A deletion mutant in the human cytomegalovirus gene encoding IE1(491aa) is replication defective due to a failure in autoregulationMultiple Transcripts Encode Full-Length Human Cytomegalovirus IE1 and IE2 Proteins during Lytic Infection.Inhibition of the association of RNA polymerase II with the preinitiation complex by a viral transcriptional repressorFunctional interaction between the human cytomegalovirus 86-kilodalton IE2 protein and the cellular transcription factor CREB.CCAAT box-dependent activation of the TATA-less human DNA polymerase alpha promoter by the human cytomegalovirus 72-kilodalton major immediate-early proteinSite-specific binding of the human cytomegalovirus IE2 86-kilodalton protein to an early gene promoter.Minor groove contacts are essential for an interaction of the human cytomegalovirus IE2 protein with its DNA target.Direct interaction of the human cytomegalovirus IE86 protein with the cis repression signal does not preclude TBP from binding to the TATA box.Separate DNA elements containing ATF/CREB and IE86 binding sites differentially regulate the human cytomegalovirus UL112-113 promoter at early and late times in the infectionThe 6-Aminoquinolone WC5 inhibits different functions of the immediate-early 2 (IE2) protein of human cytomegalovirus that are essential for viral replication.Cytomegalovirus IE2 protein stimulates interleukin 1beta gene transcription via tethering to Spi-1/PU.1.Characterization of the transcriptional repressive element of the human cytomegalovirus immediate-early US3 gene.
P2860
Q22254757-53CD48CD-B163-4A3D-8444-6A489AB3864AQ24529191-62DA7B10-385D-4AE5-8806-CA9A20ED197FQ25255330-16511D0E-26F9-4CC8-AAD1-746543DEB206Q31049140-6F91A139-13D6-4416-AD8D-0F6F132581E5Q33558299-32B3E176-0172-4E52-B371-1C9CA84716BDQ33776312-6CF772E1-FA20-482A-814D-D8C7A7BA995EQ33781947-01DE4BE7-F219-4956-9F29-EE005924B620Q33782001-F38737CC-7745-4F9B-B455-A3AFB6A24B7AQ33799527-484C3418-AD4D-44CF-8758-6A9E5283A73FQ33800239-EFDB4FAA-4276-4542-B805-F883F9FF1B5BQ33826853-94E7E6BB-5F7D-4EF8-A26F-F40EDF9DA7D6Q34720787-586CC3FD-B49A-461E-9EE9-230D433FDFA2Q34998851-61EC36AF-833B-4B09-A73B-0CBD945B9E7AQ35784878-77A4E00C-27D4-4F7A-9852-3FE8377DE0E9Q35840154-267F31D7-D354-4433-989E-064D4C5A4682Q35845633-25E7A974-AE3A-4203-A2CA-E45458D133DAQ35857758-D7964876-3239-4C43-8D59-2A4B36157516Q35861289-E0C95A8E-AD54-4983-AD5F-A7EF00A0717FQ35870737-76C7DEF1-CDAD-47FF-B873-347B97F2CAC0Q35870987-D4A5B846-0ACE-4821-9057-D3853ED16F0FQ35872328-0BCA65D8-F835-4264-AE85-1E1E3DD8E065Q35873576-FDA8B996-FBFF-4C36-BE04-AE625625B316Q35886859-D536102A-8931-4C9C-A5CA-38909D4668A2Q36626536-A8E7B232-7D21-4E1B-A75C-FE9C2695E00CQ36637352-9FA516BD-0DC0-47FD-93DC-A3BDE3244BC3Q36651434-F319BFE3-82AB-4BA7-905C-71BC7280AA89Q36653844-0CA1FFC4-98DF-41B1-BE43-72B0C2060ADFQ36898831-61CF76BE-6C43-4F75-8E8E-B7BFF9E71BE1Q37248409-C291824A-5883-46CE-A6CA-CCCF9D43FEB9Q37252997-8BE98F2D-8984-4FC5-8A8B-818A5C4B8063Q37698157-B5833F9A-10BF-45D3-A2F3-83FA656796E3Q38290895-82F09CF7-C6B5-4AF5-9614-2D1CB394573BQ38300339-4B417239-3930-4469-ACE5-845C30D1CA5AQ38304794-94FE7D61-CCA5-4FAC-B3B5-869D852D5850Q38305234-E4EABBE0-79CC-43B1-90CE-1C4E07B7D5ACQ38316296-88E7DA06-0909-40F3-A36B-E6B3B81DDF74Q38338839-B4869C4A-54A3-4915-8002-3728BA22824DQ38962962-AB2A3BC1-71ED-4841-8526-45C2C44D99D5Q39448135-8920784C-04A2-4ED6-BDBD-2D2B10129328Q39581391-680D1705-9C1B-48E5-B9E4-6BE64A277ACF
P2860
The 86-kilodalton IE-2 protein of human cytomegalovirus is a sequence-specific DNA-binding protein that interacts directly with the negative autoregulatory response element located near the cap site of the IE-1/2 enhancer-promoter.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
The 86-kilodalton IE-2 protein ...... the IE-1/2 enhancer-promoter.
@en
type
label
The 86-kilodalton IE-2 protein ...... the IE-1/2 enhancer-promoter.
@en
prefLabel
The 86-kilodalton IE-2 protein ...... the IE-1/2 enhancer-promoter.
@en
P2860
P1433
P1476
The 86-kilodalton IE-2 protein ...... f the IE-1/2 enhancer-promoter
@en
P2093
P2860
P304
P407
P577
1993-01-01T00:00:00Z