Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease.
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The Alzheimer's amyloid-degrading peptidase, neprilysin: can we control it?Mediator is a transducer of amyloid-precursor-protein-dependent nuclear signallingInsights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's diseaseAPP intracellular domain-WAVE1 pathway reduces amyloid-β production.In vitro Pb exposure disturbs the balance between Aβ production and elimination: the role of AβPP and neprilysinHistone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the alzheimer amyloid precursor proteinCurcumin inhibits the AKT/NF-κB signaling via CpG demethylation of the promoter and restoration of NEP in the N2a cell line.Epigenetic mechanisms during ageing and neurogenesis as novel therapeutic avenues in human brain disorders.Hypoxia-induced down-regulation of neprilysin by histone modification in mouse primary cortical and hippocampal neurons.Cellular prion protein expression is not regulated by the Alzheimer's amyloid precursor protein intracellular domain.The β-secretase-derived C-terminal fragment of βAPP, C99, but not Aβ, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus.Epigenetic induction of EGR-1 expression by the amyloid precursor protein during exposure to novelty.Epigenetic regulations of immediate early genes expression involved in memory formation by the amyloid precursor protein of Alzheimer diseaseLipid rafts and Alzheimer's disease: protein-lipid interactions and perturbation of signaling.Amyloid Precursor Protein (APP) Metabolites APP Intracellular Fragment (AICD), Aβ42, and Tau in Nuclear Roles.Tip off the HAT- Epigenetic control of learning and memory by Drosophila Tip60APP intracellular domain acts as a transcriptional regulator of miR-663 suppressing neuronal differentiation.Current advances in the treatment of Alzheimer's disease: focused on considerations targeting Aβ and tau.Nanoliposomes protect against human arteriole endothelial dysfunction induced by β-amyloid peptide.Endothelin-converting enzymes degrade intracellular β-amyloid produced within the endosomal/lysosomal pathway and autophagosomes.Mechanisms of Amyloid-β Peptide Clearance: Potential Therapeutic Targets for Alzheimer's Disease.Neprilysin and Aβ Clearance: Impact of the APP Intracellular Domain in NEP Regulation and Implications in Alzheimer's DiseaseNeurogenesis and Alzheimer's disease: at the crossroads.Prion protein and Alzheimer disease.Pharmacological targeting of the β-amyloid precursor protein intracellular domain.Epigenetic modifications of chronic hypoxia-mediated neurodegeneration in Alzheimer's disease.DNA methylation in neurodegenerative disorders: a missing link between genome and environment?Emerging roles of epigenetic mechanisms in Parkinson's disease.Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer's disease?The physiology of the β-amyloid precursor protein intracellular domain AICD.Neurodegeneration in Alzheimer disease: role of amyloid precursor protein and presenilin 1 intracellular signaling.Peroxisome proliferator-activated receptors and Alzheimer's disease: hitting the blood-brain barrier.From synaptic spines to nuclear signaling: nuclear and synaptic actions of the amyloid precursor protein.The amyloid precursor protein: a biochemical enigma in brain development, function and disease.Amyloid-clearing proteins and their epigenetic regulation as a therapeutic target in Alzheimer's disease.β-Amyloid peptides and amyloid plaques in Alzheimer's disease.New Insights into Epigenetic and Pharmacological Regulation of Amyloid-Degrading Enzymes.Mercury Reduces the Enzymatic Activity of Neprilysin in Differentiated SH-SY5Y Cells.Epigenetic regulation of angiotensin-converting enzyme 2 (ACE2) by SIRT1 under conditions of cell energy stress.The amyloid precursor protein represses expression of acetylcholinesterase in neuronal cell lines
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P2860
Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Neprilysin gene expression req ...... cations for Alzheimer disease.
@en
Neprilysin gene expression req ...... cations for Alzheimer disease.
@nl
type
label
Neprilysin gene expression req ...... cations for Alzheimer disease.
@en
Neprilysin gene expression req ...... cations for Alzheimer disease.
@nl
prefLabel
Neprilysin gene expression req ...... cations for Alzheimer disease.
@en
Neprilysin gene expression req ...... cations for Alzheimer disease.
@nl
P2093
P2860
P921
P356
P1433
P1476
Neprilysin gene expression req ...... cations for Alzheimer disease.
@en
P2093
Anthony J Turner
Natalia N Nalivaeva
Natalia Z Makova
Nikolai D Belyaev
P2860
P304
P356
10.1038/EMBOR.2008.222
P577
2008-12-05T00:00:00Z