Stigmasterol, a soy lipid-derived phytosterol, is an antagonist of the bile acid nuclear receptor FXR.
about
Controversies in the Mechanism of Total Parenteral Nutrition Induced PathologyThe food matrix and sterol characteristics affect the plasma cholesterol lowering of phytosterol/phytostanolFXR signaling in the enterohepatic systemPhytosterols promote liver injury and Kupffer cell activation in parenteral nutrition-associated liver disease.The natural history of cirrhosis from parenteral nutrition-associated liver disease after resolution of cholestasis with parenteral fish oil therapy.Nuclear receptors: mediators and modifiers of inflammation-induced cholestasis.Pharmacophore-based discovery of FXR agonists. Part I: Model development and experimental validation.Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation.The use of Omegaven in treating parenteral nutrition-associated liver disease.Total parenteral nutrition-associated cholestasis and risk factors in preterm infants.Pediatric intestinal failure-associated liver disease is reversed with 6 months of intravenous fish oilDeciphering the nuclear bile acid receptor FXR paradigm.Phytosterols differentially influence ABC transporter expression, cholesterol efflux and inflammatory cytokine secretion in macrophage foam cells.Relation of cholesterol metabolism to pediatric gallstone disease: a retrospective controlled study.The relationship between the parenteral dose of fish oil supplementation and the variation of liver function tests in hospitalized adult patientsVitamin E in New-Generation Lipid Emulsions Protects Against Parenteral Nutrition-Associated Liver Disease in Parenteral Nutrition-Fed Preterm PigsLow-Dose Intravenous Soybean Oil Emulsion for Prevention of Cholestasis in Preterm Neonates.Kinetics of phytosterol metabolism in neonates receiving parenteral nutritionIntravenous Lipid Emulsions in Parenteral NutritionEnteral High Fat-Polyunsaturated Fatty Acid Blend Alters the Pathogen Composition of the Intestinal Microbiome in Premature Infants with an Enterostomy.The ABCG5 ABCG8 sterol transporter opposes the development of fatty liver disease and loss of glycemic control independently of phytosterol accumulationSteroidal compounds in commercial parenteral lipid emulsions.Synthesis and biological evaluations of chalcones, flavones and chromenes as farnesoid x receptor (FXR) antagonists.Unifying mechanisms of action of the anticancer activities of triterpenoids and synthetic analogs.The use of fish oil lipid emulsion in the treatment of intestinal failure associated liver disease (IFALD).Short-term intravenous fish oil and pediatric intestinal failure associated liver disease: 3-year follow-up on liver function and nutrition.Dietary xenosterols lead to infertility and loss of abdominal adipose tissue in sterolin-deficient mice.Nuclear receptors as drug targets in cholestatic liver diseases.Biological models for phytochemical research: from cell to human organism.Treatment of parenteral nutrition-associated liver disease: the role of lipid emulsions.The role of FXR in disorders of bile acid homeostasis.Fish oil-based lipid emulsions in the treatment of parenteral nutrition-associated liver disease: an ongoing positive experience.Fish oil-based lipid emulsions prevent and reverse parenteral nutrition-associated liver disease: the Boston experience.New generation lipid emulsions prevent PNALD in chronic parenterally fed preterm pigs.Complications associated with parenteral nutrition in the neonate.Transcriptomic responses of the liver and adipose tissues to altered carbohydrate-fat ratio in diet: an isoenergetic study in young ratsProvision of a soy-based intravenous lipid emulsion at 1 g/kg/d does not prevent cholestasis in neonates.Bile acid transporters and regulatory nuclear receptors in the liver and beyondThe impact of farnesoid X receptor activation on intestinal permeability in inflammatory bowel disease.Review and clinical update on parenteral nutrition-associated liver disease.
P2860
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P2860
Stigmasterol, a soy lipid-derived phytosterol, is an antagonist of the bile acid nuclear receptor FXR.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Stigmasterol, a soy lipid-deri ...... ile acid nuclear receptor FXR.
@en
type
label
Stigmasterol, a soy lipid-deri ...... ile acid nuclear receptor FXR.
@en
prefLabel
Stigmasterol, a soy lipid-deri ...... ile acid nuclear receptor FXR.
@en
P2093
P2860
P1433
P1476
Stigmasterol, a soy lipid-deri ...... ile acid nuclear receptor FXR.
@en
P2093
Beth A Carter
Daniel R Prendergast
David D Moore
Olga A Taylor
Richard Von Furstenberg
Saul J Karpen
Tracy L Zimmerman
P2860
P2888
P304
P356
10.1203/PDR.0B013E3181256492
P407
P577
2007-09-01T00:00:00Z
P6179
1027393865