Small-molecule inhibitors of protein geranylgeranyltransferase type I.
about
Identification and characterization of mechanism of action of P61-E7, a novel phosphine catalysis-based inhibitor of geranylgeranyltransferase-IAplexone targets the HMG-CoA reductase pathway and differentially regulates arteriovenous angiogenesis.Novel three-component synthesis and antiproliferative properties of diversely functionalized pyrrolinesInhibitors of protein geranylgeranyltransferase I and Rab geranylgeranyltransferase identified from a library of allenoate-derived compounds.In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-IDiversity through a branched reaction pathway: generation of multicyclic scaffolds and identification of antimigratory agents.Diversity through phosphine catalysis identifies octahydro-1,6-naphthyridin-4-ones as activators of endothelium-driven immunity.Phosphine-catalyzed [4+2] annulations of 2-alkylallenoates and olefins: synthesis of multisubstituted cyclohexenesDiversity-oriented synthesis based on the DPPP-catalyzed mixed double-Michael reactions of electron-deficient acetylenes and β-amino alcohols.A small molecule inhibitor of redox-regulated protein translocation into mitochondriaHydroxyproline-derived pseudoenantiomeric [2.2.1] bicyclic phosphines: asymmetric synthesis of (+)- and (-)-pyrrolines.PHOSPHINE-CATALYZED [3 + 2] ANNULATION: SYNTHESIS OF ETHYL 5-(tert-BUTYL)-2-PHENYL-1-TOSYL-3-PYRROLINE-3-CARBOXYLATEIn vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cellsPhosphine-Catalyzed [3+2] and [4+3]Annulation Reactions of C,N-Cyclic Azomethine Imines with AllenoatesMitochondrial Ca(2+) uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity.Scaling out by microwave-assisted, continuous flow organic synthesis (MACOS): multi-gram synthesis of bromo- and fluoro-benzofused sultams benzthiaoxazepine-1,1-dioxidesPhosphine-catalyzed annulations of azomethine imines: allene-dependent [3 + 2], [3 + 3], [4 + 3], and [3 + 2 + 3] pathways.Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival.Use of a new spirophosphine to achieve catalytic enantioselective [4 + 1] annulations of amines with allenes to generate dihydropyrrolesSignificance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesisNanoformulation of Geranylgeranyltransferase-I Inhibitors for Cancer Therapy: Liposomal Encapsulation and pH-Dependent Delivery to Cancer Cells.Enantioselective total synthesis of (+)-ibophyllidine via an asymmetric phosphine-catalyzed [3 + 2] annulation.PHOSPHINE-CATALYZED [4+2] ANNULATION: SYNTHESIS OF ETHYL 6-PHENYL-1-TOSYL-1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXYLATE.Discovery of geranylgeranyltransferase-I inhibitors with novel scaffolds by the means of quantitative structure-activity relationship modeling, virtual screening, and experimental validation.Advances in nucleophilic phosphine catalysis of alkenes, allenes, alkynes, and MBHADs.Nucleophilic Chiral Phosphines: Powerful and Versatile Catalysts for Asymmetric AnnulationsModule assembly for designing multivalent mid-sized inhibitors of protein-protein interactions.Phosphine catalysis of allenes with electrophiles.Annulations of enantioenriched allenylsilanes with in situ generated iminium ions: stereoselective synthesis of diverse heterocycles.Synthesis and evaluation of 3- and 7-substituted geranylgeranyl pyrophosphate analogs.Phosphine-initiated general base catalysis: facile access to benzannulated 1,3-diheteroatom five-membered rings via double-Michael reactions of allenes.Theory-Guided Design of Brønsted Acid-Assisted Phosphine Catalysis: Synthesis of Dihydropyrones from Aldehydes and Allenoates.Phosphine-catalyzed [4 + 2] annulation: synthesis of cyclohexenes.Bisphosphine-catalyzed mixed double-Michael reactions: asymmetric synthesis of oxazolidines, thiazolidines, and pyrrolidines.Phosphine-catalyzed intramolecular γ-umpolung addition of α-aminoalkylallenic esters: facile synthesis of 3-carbethoxy-2-alkyl-3-pyrrolines.Alcohol-assisted phosphine catalysis: one-step syntheses of dihydropyrones from aldehydes and allenoates."Click, click, cyclize": a DOS approach to sultams utilizing vinyl sulfonamide linchpins.Phosphine-catalyzed β'-umpolung addition of nucleophiles to activated α-alkyl allenes.Phosphine-containing Lewis base catalyzed cyclization of benzofuranone type electron-deficient alkenes with allenoates: a facile synthesis of spirocyclic benzofuranones.Formation of N-sulfonyl imines from iminoiodinanes by iodine-promoted, N-centered radical sulfonamidation of aldehydes.
P2860
Q28477527-BD2E9155-02AD-489A-BA17-91BF40B1EE9AQ30498222-C942E3D7-15CC-4D2C-9F92-E3E0EC50A29CQ33316600-0733B7E9-BF25-4129-8758-7287B4E63655Q33317126-5B0EE2FC-8C14-43CE-A257-29C73EB8E01BQ33439394-084701EC-1B23-47F1-85C3-56F59CB16CCEQ33786011-82B62FDD-A252-4556-91BA-DC02D7FFF6A9Q33839073-C20E2B69-1A4F-43D9-AB93-38544CA6A1BEQ34004474-296B1D62-CF15-4565-A7C3-D96E3FEFAFBCQ34020882-30830BD4-B6BA-44CB-8410-CFFD1275624DQ34036402-2424AE89-36A3-4310-B011-A532812AAE85Q34120280-79CA104C-9749-4FAB-9AB1-EF08E109F9E0Q34637917-69803EDF-CE32-4D76-A9C1-A29E19A7B4E3Q34680671-980B1086-03E6-4FE3-AF19-7E89B3FBCB61Q34706915-2652341E-1FA2-493F-9F52-5AE2419FA645Q34949313-28D6A0C2-8BC8-46CC-8632-B50E4BB3B279Q35133469-35CF2DC0-3A37-4987-837D-9D076433984AQ35184786-6A1CDDB9-DB07-4133-9CBB-94209A4D23C4Q35472210-3098478E-B5A0-4F20-A45D-D77914ECF6A9Q35610315-F66852AB-6BD5-4F29-A591-19D71003E0E5Q35625798-7A7E2200-33C1-43FE-B15B-E42E1DD01506Q35767648-AC9C255E-6964-4130-AB83-418F5848D494Q36085820-30999865-446C-4247-ADF3-8E0B0D9BE8BAQ37271990-1D076677-8147-46E5-B7E8-2E61F8747C14Q37304601-AF7B8442-EED6-4E93-A8AC-9117E7A38AB2Q37495686-2C2A1F1E-8802-4AD7-B8F8-DC61ABE635CDQ37574112-9B146806-F19F-4629-85EA-5B3C425A5144Q38168810-207CC831-60ED-42C0-B9A4-A3C2EE9F6947Q38198956-3D1F7A62-B3CD-4677-8084-340B6364119DQ38273618-97B88013-8F9D-4CA1-B859-6AC842486110Q38291087-99B31773-7C32-480D-8F91-10C81D0BB1DBQ38708680-F76F26ED-5365-4337-8EC3-837C38197E5AQ41115696-73103F55-431E-4531-8EC9-584D562BFAE2Q41822465-2699BDF4-ECD0-4C7C-A316-93058049A884Q41828894-E0BA3005-CB99-49A6-8127-F8C53259DEA4Q42094790-F714A129-8DFC-460F-822A-AD2E28139A8DQ42150888-E1E4F183-3F00-4624-9119-826DD89EE7CCQ42553763-1B44BF05-F79B-4AFB-A1EF-EB533C257CAFQ42733767-D2650D7B-6419-45AF-B395-6BC5CE90EDAFQ43636962-D296B3C3-2112-4141-9294-B24EB78AC2DBQ46273386-F68F1BEB-85CD-4825-B103-936DA0576CD4
P2860
Small-molecule inhibitors of protein geranylgeranyltransferase type I.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Small-molecule inhibitors of protein geranylgeranyltransferase type I.
@en
type
label
Small-molecule inhibitors of protein geranylgeranyltransferase type I.
@en
prefLabel
Small-molecule inhibitors of protein geranylgeranyltransferase type I.
@en
P2093
P2860
P356
P1476
Small-molecule inhibitors of protein geranylgeranyltransferase type I.
@en
P2093
Fuyuhiko Tamanoi
Hannah D G Fiji
Masaru Watanabe
Ohyun Kwon
Pablo de Leon
Sape S Kinderman
P2860
P304
P356
10.1021/JA070274N
P407
P577
2007-04-17T00:00:00Z