Definition of pRB- and p53-dependent and -independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci. - Wikidata - awgldk - TriplyDB

Definition of pRB- and p53-dependent and -independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci.

Definition of pRB- and p53-dependent and -independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci.

http://www.wikidata.org/entity/Q40180222

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PML nuclear bodies Mitogen-activated protein kinase p38 and retinoblastoma protein signalling is required for DNA damage-mediated formation of senescence-associated heterochromatic foci in tumour cells Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging Molecular dissection of formation of senescence-associated heterochromatin foci The cell biology of disease: Acute promyelocytic leukemia, arsenic, and PML bodies Oxidative stress and epigenetic regulation in ageing and age-related diseases Disruptive chemicals, senescence and immortality Therapeutic targeting of replicative immortality Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells.Drosophila Yemanuclein and HIRA cooperate for de novo assembly of H3.3-containing nucleosomes in the male pronucleus Role of chromatin during herpesvirus infections.Changed genome heterochromatinization upon prolonged activation of the Raf/ERK signaling pathway.HP1-mediated formation of alternative lengthening of telomeres-associated PML bodies requires HIRA but not ASF1a.Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci.Ring-like distribution of constitutive heterochromatin in bovine senescent cells.PML-mediated signaling and its role in cancer stem cells.Escherichia coli producing colibactin triggers premature and transmissible senescence in mammalian cells.Asf1/HIRA facilitate global histone deacetylation and associate with HP1 to promote nucleosome occupancy at heterochromatic loci.A kinase shRNA screen links LATS2 and the pRB tumor suppressor Antagonistic TSC22D1 variants control BRAF(E600)-induced senescence.Wnt5a suppresses epithelial ovarian cancer by promoting cellular senescence.Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex.Oncogenic RAS regulates BRIP1 expression to induce dissociation of BRCA1 from chromatin, inhibit DNA repair, and promote senescence.Linking DNA replication to heterochromatin silencing and epigenetic inheritance POZ/BTB and AT-hook-containing zinc finger protein 1 (PATZ1) inhibits endothelial cell senescence through a p53 dependent pathway.Retinoblastoma protein promotes oxidative phosphorylation through upregulation of glycolytic genes in oncogene-induced senescent cells.JMJD3 promotes SAHF formation in senescent WI38 cells by triggering an interplay between demethylation and phosphorylation of RB protein.Interleukin 6 signaling regulates promyelocytic leukemia protein gene expression in human normal and cancer cells.Detection of senescence-associated heterochromatin foci (SAHF).Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells.BRG1 is required for formation of senescence-associated heterochromatin foci induced by oncogenic RAS or BRCA1 loss Aging by epigenetics--a consequence of chromatin damage?Clothing up DNA for all seasons: Histone chaperones and nucleosome assembly pathways.Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability.Induction of cellular senescence by secretory phospholipase A2 in human dermal fibroblasts through an ROS-mediated p53 pathway.New insights into the role of PML in tumour suppression.Oncogene-induced senescence: an essential role for Runx.Lessons from senescence: Chromatin maintenance in non-proliferating cells.Dynamics of histone H3.3 deposition in proliferating and senescent cells reveals a DAXX-dependent targeting to PML-NBs important for pericentromeric heterochromatin organization.Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer.

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P2860

Definition of pRB- and p53-dependent and -independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci.

http://www.wikidata.org/entity/Q40180222

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2007 nî lūn-bûn

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Definition of pRB- and p53-dep ...... sociated heterochromatin foci.

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Definition of pRB- and p53-dep ...... sociated heterochromatin foci.

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Definition of pRB- and p53-dep ...... sociated heterochromatin foci.

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Molecular and Cellular Biology

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Definition of pRB- and p53-dep ...... sociated heterochromatin foci.

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P2093

Brad Zerlanko

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Marc Lipinski

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Neeta Somaiah

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Paolo Salomoni

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Peter D Adams

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Rugang Zhang

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Xiaofen Ye

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P2860

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

Regulation of p53 activity in nuclear bodies by a specific PML isoform

Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA

Extension of life-span by introduction of telomerase into normal human cells

Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1

HIRA, the human homologue of yeast Hir1p and Hir2p, is a novel cyclin-cdk2 substrate whose expression blocks S-phase progression

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

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2452-2465

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10.1128/MCB.01592-06

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7

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27

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17242198

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1899904

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