A novel low-molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth.
about
Glioblastoma angiogenesis and tumor cell invasiveness are differentially regulated by β8 integrinFAK and paxillin, two potential targets in pancreatic cancerFAK in cancer: mechanistic findings and clinical applicationsTumor cell migration in complex microenvironmentsAltering FAK-paxillin interactions reduces adhesion, migration and invasion processesCrystal Structures of the FAK Kinase in Complex with TAE226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical DFG ConformationTAE226, a Bis-Anilino Pyrimidine Compound, Inhibits the EGFR-Mutant Kinase Including T790M Mutant to Show Anti-Tumor Effect on EGFR-Mutant Non-Small Cell Lung Cancer CellsDiscovery of novel focal adhesion kinase inhibitors using a hybrid protocol of virtual screening approach based on multicomplex-based pharmacophore and molecular dockingFocal adhesion kinase as a regulator of cell tension in the progression of cancer.Activation of focal adhesion kinase and JNK contributes to the extracellular matrix and cAMP-GEF mediated survival from bile acid induced apoptosis in rat hepatocytesTherapeutic strategies for inhibiting invasion in glioblastoma.Molecular and cellular impact of Psoriasin (S100A7) on the healing of human wounds.The Ras-related protein, Rap1A, mediates thrombin-stimulated, integrin-dependent glioblastoma cell proliferation and tumor growthInhibition of focal adhesion kinase decreases tumor growth in human neuroblastomaG(12/13) signaling pathways substitute for integrin αIIbβ3-signaling for thromboxane generation in platelets.Mesenchymal migration as a therapeutic target in glioblastoma.Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models.PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments.Targeting Pyk2 for therapeutic interventionαvβ8 integrin interacts with RhoGDI1 to regulate Rac1 and Cdc42 activation and drive glioblastoma cell invasion.Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism.Understanding the roles of FAK in cancer: inhibitors, genetic models, and new insightsA novel strategy to inhibit FAK and IGF-1R decreases growth of pancreatic cancer xenograftsInhibition of FAK and VEGFR-3 binding decreases tumorigenicity in neuroblastoma.MYCN, neuroblastoma and focal adhesion kinase (FAK)Targeting focal adhesion kinase in neuroblastoma.Acquisition of meiotic DNA repair regulators maintain genome stability in glioblastoma.Focal adhesion kinase signaling mediates acute renal injury induced by ischemia/reperfusion.Pharmacological strategies to overcome HER2 cross-talk and Trastuzumab resistance.Post-radiation increase in VEGF enhances glioma cell motility in vitroKinases as targets for chemical modulators: Structural aspects and their role in spermatogenesis.Focal Adhesion Kinase: Insight into Molecular Roles and Functions in Hepatocellular CarcinomaThe role of semaphorins and their receptors in gliomasTopography induces differential sensitivity on cancer cell proliferation via Rho-ROCK-Myosin contractility.Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK.Bacitracin Inhibits the Migration of U87-MG Glioma Cells via Interferences of the Integrin Outside-in Signaling Pathway.FAK inhibition decreases cell invasion, migration and metastasis in MYCN amplified neuroblastomaA novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer.Expression of focal adhesion kinase in small-cell lung carcinoma.Diffuse glioma growth: a guerilla war
P2860
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P2860
A novel low-molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
A novel low-molecular weight i ...... AE226, inhibits glioma growth.
@en
type
label
A novel low-molecular weight i ...... AE226, inhibits glioma growth.
@en
prefLabel
A novel low-molecular weight i ...... AE226, inhibits glioma growth.
@en
P2093
P2860
P50
P356
P1476
A novel low-molecular weight i ...... AE226, inhibits glioma growth.
@en
P2093
Dowdy Jackson
Jeremy N Rich
Linhua Song
Osamu Ohmori
Sarah Wickman
Stephen T Keir
P2860
P304
P356
10.1002/MC.20297
P577
2007-06-01T00:00:00Z