Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins.
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Small-molecule Bcl-2 antagonists as targeted therapy in oncologyBH3 mimetics to improve cancer therapy; mechanisms and examplesBcl-2 antagonists: a proof of concept for CLL therapyThe role of BH3-mimetic drugs in the treatment of pediatric hepatoblastomaTargeting BCL2-Proteins for the Treatment of Solid TumoursTargeting the Bcl-2 family for cancer therapyFeatures of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinityBAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial poreThe MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizerIn vitro models of cancer stem cells and clinical applicationsPutting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy?Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasisSelectivity by small-molecule inhibitors of protein interactions can be driven by protein surface fluctuationsBiological Stereoselectivity of Atropisomeric Natural Products and DrugsAcanthamoeba myosin IC colocalizes with phosphatidylinositol 4,5-bisphosphate at the plasma membrane due to the high concentration of negative chargeA competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survivalApogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteinsVoltage-dependent anion channel 1-based peptides interact with Bcl-2 to prevent antiapoptotic activity.Emerging Bcl-2 inhibitors for the treatment of cancer.RhoA/ROCK/PTEN signaling is involved in AT-101-mediated apoptosis in human leukemia cells in vitro and in vivo.A dual-readout F2 assay that combines fluorescence resonance energy transfer and fluorescence polarization for monitoring bimolecular interactions.PUMA mediates EGFR tyrosine kinase inhibitor-induced apoptosis in head and neck cancer cellsDiscovery and development of thiazolo[3,2-a]pyrimidinone derivatives as general inhibitors of Bcl-2 family proteins.Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo.Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factorsPhosphoproteomic analysis of gossypol-induced apoptosis in ovarian cancer cell line, HOC1a.Proteomic analysis of gossypol induces necrosis in multiple myeloma cells.Metronomic small molecule inhibitor of Bcl-2 (TW-37) is antiangiogenic and potentiates the antitumor effect of ionizing radiationB cell lymphoma-2 (BCL-2) homology domain 3 (BH3) mimetics demonstrate differential activities dependent upon the functional repertoire of pro- and anti-apoptotic BCL-2 family proteins.Amphipathic tail-anchoring peptide and Bcl-2 homology domain-3 (BH3) peptides from Bcl-2 family proteins induce apoptosis through different mechanismsSynthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteinsMelanoma proliferation and chemoresistance controlled by the DEK oncogeneSmall molecule inhibitors of bcl-2 family proteins for pancreatic cancer therapyA cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma.Small-molecule inhibitor of Bcl-2 (TW-37) suppresses growth and enhances cisplatin-induced apoptosis in ovarian cancer cells.The Role of BH3-Only Proteins in Tumor Cell Development, Signaling, and Treatment.Inhibitory activity of apogossypol in human prostate cancer in vitro and in vivoSmall molecule inhibition of the steroid receptor coactivators, SRC-3 and SRC-1.BH3 Profiling Reveals Selectivity by Herpesviruses for Specific Bcl-2 Proteins To Mediate Survival of Latently Infected Cells.Small-Molecule and Peptide Inhibitors of the Pro-Survival Protein Mcl-1
P2860
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P2860
Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Structure-based design of pote ...... anti-apoptotic Bcl-2 proteins.
@en
type
label
Structure-based design of pote ...... anti-apoptotic Bcl-2 proteins.
@en
prefLabel
Structure-based design of pote ...... anti-apoptotic Bcl-2 proteins.
@en
P2093
P356
P1476
Structure-based design of pote ...... anti-apoptotic Bcl-2 proteins.
@en
P2093
Chao-Yie Yang
Dajun Yang
Guoping Wang
Hatice Ozel Abaan
Jeanne Stuckey
Jennifer Meagher
Krzysztof Krajewski
Peter P Roller
Renxiao Wang
P304
P356
10.1021/JM060460O
P407
P50
P577
2006-10-01T00:00:00Z