Evaluation of 170 xenobiotics as transactivators of human pregnane X receptor (hPXR) and correlation to known CYP3A4 drug interactions.
about
Biology of PXR: role in drug-hormone interactionsTargeting xenobiotic receptors PXR and CAR for metabolic diseasesIdentification of clinically used drugs that activate pregnane X receptorsDevelopment of a common carp (Cyprinus carpio) pregnane X receptor (cPXR) transactivation reporter assay and its activation by azole fungicides and pharmaceutical chemicals.Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation.Overcoming drug resistance by regulating nuclear receptors.Differential activation of pregnane X receptor and constitutive androstane receptor by buprenorphine in primary human hepatocytes and HepG2 cells.Cell-based systems to assess nuclear receptor activation and their use in drug development.Thiazide-like diuretic drug metolazone activates human pregnane X receptor to induce cytochrome 3A4 and multidrug-resistance protein 1.Differential drug resistance acquisition to doxorubicin and paclitaxel in breast cancer cells.Evaluation of the pharmacokinetic interaction between repeated doses of rifapentine or rifampin and a single dose of bedaquiline in healthy adult subjects.Serine 350 of human pregnane X receptor is crucial for its heterodimerization with retinoid X receptor alpha and transactivation of target genes in vitro and in vivoSmall-molecule modulators of PXR and CAR.Human PXR-mediated induction of intestinal CYP3A4 attenuates 1α,25-dihydroxyvitamin D₃ function in human colon adenocarcinoma LS180 cells.Three new shRNA expression vectors targeting the CYP3A4 coding sequence to inhibit its expressionA comprehensive in vitro and in silico analysis of antibiotics that activate pregnane X receptor and induce CYP3A4 in liver and intestine.The pregnane X receptor in tuberculosis therapeutics.Identification of novel activators of constitutive androstane receptor from FDA-approved drugs by integrated computational and biological approaches.Machine learning methods and docking for predicting human pregnane X receptor activation.Cytochrome P450 reaction-phenotyping: an industrial perspective.PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics.BDE47 induces rat CYP3A1 by targeting the transcriptional regulation of miR-23b.Current industrial practices in assessing CYP450 enzyme induction: preclinical and clinicalActivity, inhibition, and induction of cytochrome P450 2J2 in adult human primary cardiomyocytes.Activation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) by herbal medicines.Evaluation of models for predicting drug-drug interactions due to induction.Methods for the quantitative evaluation and prediction of CYP enzyme induction using human in vitro systems.Evaluation of pregnane X receptor (PXR)-mediated CYP3A4 drug-drug interactions in drug development.Advances in predicting CYP-mediated drug interactions in the drug discovery setting.Post-translational and post-transcriptional modifications of pregnane X receptor (PXR) in regulation of the cytochrome P450 superfamily.Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction.Advantages of cell-based high-volume screening assays to assess nuclear receptor activation during drug discovery.Nuclear hormone receptors PXR and CAR and metabolic diseases.The regulation of human hepatic drug transporter expression by activation of xenobiotic-sensing nuclear receptors.BFCOD activity in fish cell lines and zebrafish embryos and its modulation by chemical ligands of human aryl hydrocarbon and nuclear receptors.Managing the Risk of CYP3A Induction in Drug Development: A Strategic Approach.Efficient assessment of the utility of immortalized Fa2N-4 cells for cytochrome P450 (CYP) induction studies using multiplex quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and substrate cassette methodologies.Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cellsUse of cryopreserved transiently transfected cells in high-throughput pregnane X receptor transactivation assay.Studies on the pharmacokinetics and metabolism of a gamma-secretase inhibitor BMS-299897, and exploratory investigation of CYP enzyme induction.
P2860
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P2860
Evaluation of 170 xenobiotics as transactivators of human pregnane X receptor (hPXR) and correlation to known CYP3A4 drug interactions.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Evaluation of 170 xenobiotics ...... nown CYP3A4 drug interactions.
@en
type
label
Evaluation of 170 xenobiotics ...... nown CYP3A4 drug interactions.
@en
prefLabel
Evaluation of 170 xenobiotics ...... nown CYP3A4 drug interactions.
@en
P2093
P1476
Evaluation of 170 xenobiotics ...... nown CYP3A4 drug interactions.
@en
P2093
A David Rodrigues
Kenneth Dickinson
Michael Sinz
Monique Anthony
Taosheng Chen
Zhengrong Zhu
P304
P356
10.2174/138920006776873535
P407
P577
2006-05-01T00:00:00Z