Novel 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists with improved cellular activity.
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Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapyChemical Variations on the p53 Reactivation ThemeDesign, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions.Microwave-assisted fluorous synthesis of a 1,4-benzodiazepine-2,5-dione library.1,4-Thienodiazepine-2,5-diones via MCR (II): scaffold hopping by Gewald and Ugi-deprotection-cyclization strategyPrivileged diazepine compounds and their emergence as bromodomain inhibitors.Synthesis of phantasmidineChemistry and biology of multicomponent reactions.The p53-MDM2/MDMX axis - A chemotype perspective.Isocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics.1,4-Thienodiazepine-2,5-diones via MCR (I): synthesis, virtual space and p53-Mdm2 activity.Docking Analysis and Multidimensional Hybrid QSAR Model of 1,4-Benzodiazepine-2,5-Diones as HDM2 Antagonists.Structural determinants of benzodiazepinedione/peptide-based p53-HDM2 inhibitors using 3D-QSAR, docking and molecular dynamics.
P2860
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P2860
Novel 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists with improved cellular activity.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Novel 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists with improved cellular activity.
@en
type
label
Novel 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists with improved cellular activity.
@en
prefLabel
Novel 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists with improved cellular activity.
@en
P2093
P1476
Novel 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists with improved cellular activity.
@en
P2093
Anna C Maroney
Holly K Koblish
Jennifer Lattanze
Joan M Gushue
Juan Jose Marugan
Kristi Leonard
Mark R Player
Maxwell D Cummings
Pierre Raboisson
Raul Calvo
P304
P356
10.1016/J.BMCL.2006.04.009
P407
P577
2006-05-02T00:00:00Z