Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants.
about
Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugsX-ray structure of dopamine transporter elucidates antidepressant mechanismThe binding sites for cocaine and dopamine in the dopamine transporter overlapAntidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structuresComparative molecular field analysis using selectivity fields reveals residues in the third transmembrane helix of the serotonin transporter associated with substrate and antagonist recognitionHow LeuT shapes our understanding of the mechanisms of sodium-coupled neurotransmitter transportersA steered molecular dynamics study of binding and translocation processes in the GABA transporterIntegrin β3 Haploinsufficiency Modulates Serotonin Transport and Antidepressant-Sensitive Behavior in MiceA competitive inhibitor traps LeuT in an open-to-out conformation.Structural basis for action by diverse antidepressants on biogenic amine transportersTwo allelic isoforms of the serotonin transporter from Schistosoma mansoni display electrogenic transport and high selectivity for serotoninAssessing the ability of sequence-based methods to provide functional insight within membrane integral proteins: a case study analyzing the neurotransmitter/Na+ symporter family.4-(4-(dimethylamino)phenyl)-1-methylpyridinium (APP+) is a fluorescent substrate for the human serotonin transporter.Binding and orientation of tricyclic antidepressants within the central substrate site of the human serotonin transporter.Transmembrane domain 6 of the human serotonin transporter contributes to an aqueously accessible binding pocket for serotonin and the psychostimulant 3,4-methylene dioxymethamphetamine.Structural analysis of the extracellular entrance to the serotonin transporter permeation pathway.Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile) analogues at monoamine transportersThe high-affinity binding site for tricyclic antidepressants resides in the outer vestibule of the serotonin transporter.Pharmaceuticals as neuroendocrine disruptors: lessons learned from fish on Prozac.Discovery of novel-scaffold monoamine transporter ligands via in silico screening with the S1 pocket of the serotonin transporterComputational and biochemical docking of the irreversible cocaine analog RTI 82 directly demonstrates ligand positioning in the dopamine transporter central substrate-binding site.X-ray structures and mechanism of the human serotonin transporter.Development of Therapeutics That Induce Mitochondrial Biogenesis for the Treatment of Acute and Chronic Degenerative Diseases.Transgenic elimination of high-affinity antidepressant and cocaine sensitivity in the presynaptic serotonin transporter.SLC6 transporters: structure, function, regulation, disease association and therapeuticsMotoneuron excitability and muscle spasms are regulated by 5-HT2B and 5-HT2C receptor activity.Interaction of cocaine-, benztropine-, and GBR12909-like compounds with wild-type and mutant human dopamine transporters: molecular features that differentially determine antagonist-binding properties.Location of the antidepressant binding site in the serotonin transporter: importance of Ser-438 in recognition of citalopram and tricyclic antidepressants.Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter.Molecular determinants for selective recognition of antidepressants in the human serotonin and norepinephrine transporters.Antagonist-induced conformational changes in dopamine transporter extracellular loop two involve residues in a potential salt bridgeMonoamine transporters: vulnerable and vital doorkeepers.Novel Azido-Iodo Photoaffinity Ligands for the Human Serotonin Transporter Based on the Selective Serotonin Reuptake Inhibitor (S)-Citalopram.Molecular mechanism of serotonin transporter inhibition elucidated by a new flexible docking protocol.Synthesis, in vitro binding studies and docking of long-chain arylpiperazine nitroquipazine analogues, as potential serotonin transporter inhibitors.The SSRI citalopram affects fetal thalamic axon responsiveness to netrin-1 in vitro independently of SERT antagonism.The solute carrier 6 family of transportersSteric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporterEngineered zinc-binding sites confirm proximity and orientation of transmembrane helices I and III in the human serotonin transporter.Mechanism of Paroxetine (Paxil) Inhibition of the Serotonin Transporter.
P2860
Q21262013-D8CCEF0D-C24D-4F04-AFD9-041C381D6F83Q24612997-3397BADB-290E-484B-B285-AD2F305B3703Q24650126-7129CE98-E80A-4F56-A95D-435ED4580B4FQ24655640-C35CB5AB-5E63-402B-8883-288620AE079CQ24656589-70BD1C6B-4DB0-480A-A7AC-9D2E3ABA047FQ26866308-18A06D66-B9E5-4453-9199-E12891707C61Q27300859-3D9448AF-2AA6-4AE5-A72F-89F0A209532EQ27310702-57F86510-BF45-4189-BF30-C3C607B0D1BBQ27653127-C84B652E-BED6-460E-97DC-D8DC141C9B13Q27680298-62299BB5-9A9B-4DF1-BB69-72908605E44CQ28751482-B02645A7-772C-4EA5-A089-DB1E185F6119Q30481053-0FBF7675-FFC5-478E-8F38-C9904B2F8652Q30511824-1B30E876-05BA-4283-B9F3-47848660B568Q33707171-C8487A73-58AA-4093-8142-D6EE17EC5D1EQ33799683-016D5AEC-D5BE-43AD-96B8-84E9964F2CBCQ33832622-5841871E-B78B-44CC-B514-0582C80B2AE1Q34102188-87271BDE-6CB2-4CDD-A78E-663C305674E9Q34137102-10111A70-4B15-4644-99A6-ECA81688F4E5Q34203601-41A015F0-950C-4669-A940-C170CA5F71A7Q34249476-270C7F01-F2C2-4797-8C7B-A25648E9A1DDQ34396818-5CF7E3A7-49D7-42A2-8575-EEA4DE9D802FQ34521033-1E1B0AD0-DB1B-4927-9626-3A6A343F715BQ34538482-85CB1D7E-3255-4192-98CF-DB617D9749F9Q34621173-7D50A184-D7DA-43CD-BA04-74E7D35256A7Q34649517-B5037C56-A011-4D53-AE05-D6BB6E012AF3Q34686451-0052818B-FE4E-4E3A-9D15-9A129CF4BEE0Q34825605-5F4712BA-7B42-406B-92A0-4D4ACC52D779Q34943864-C3CF7C7E-EACF-4E87-BD68-75DF03303AB3Q35011459-4AE8CED5-CBE3-4D0A-B47B-083B453DDBFEQ35123142-8EBB1CB7-E0DF-414A-AD9E-7E263FD38DF2Q35383366-0D3CD47F-8A21-4A5F-8B1E-DFC966EE9EC0Q35877150-721FAA8A-F83A-49EA-94AD-DEDDAE307101Q35891263-73727E41-3187-432F-9B8E-BBB1C0F0A1F1Q35975646-4D4A6953-7CAF-4322-9091-2463BE2A7F8AQ36002440-0AF7136B-ABE7-4167-A159-C8959E41A983Q36035922-099C5A32-2C2A-4EE8-A665-2B64875F05E0Q36346899-C38EB29E-DD98-4ACB-9A5D-BB3FE5EE8C53Q36407799-902D6FA0-71DC-43C7-9F83-267C93D378D7Q36458026-F58006A9-FDA6-4A9B-ADAF-23ADD7B7CD61Q36754967-B0DE73E2-E032-44D1-BBEA-1603A4936661
P2860
Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Tyr-95 and Ile-172 in transmem ...... ecognition of antidepressants.
@en
type
label
Tyr-95 and Ile-172 in transmem ...... ecognition of antidepressants.
@en
prefLabel
Tyr-95 and Ile-172 in transmem ...... ecognition of antidepressants.
@en
P2093
P2860
P356
P1476
Tyr-95 and Ile-172 in transmem ...... ecognition of antidepressants.
@en
P2093
Erika M Adkins
Julie R Field
L Keith Henry
M Laura Parnas
Randy D Blakely
Roxanne A Vaughan
P2860
P304
P356
10.1074/JBC.M505055200
P407
P577
2005-11-03T00:00:00Z