The chaperone-associated ubiquitin ligase CHIP is able to target p53 for proteasomal degradation.
about
p53-induced growth arrest is regulated by the mitochondrial SirT3 deacetylaseBAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP.Docking-dependent ubiquitination of the interferon regulatory factor-1 tumor suppressor protein by the ubiquitin ligase CHIPRegulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexesCHIP: A new modulator of human malignant disordersMolecular chaperones in targeting misfolded proteins for ubiquitin-dependent degradationQuality control and fate determination of Hsp90 client proteinsMolecular Mechanism of the Negative Regulation of Smad1/5 Protein by Carboxyl Terminus of Hsc70-interacting Protein (CHIP)A Decade of Boon or Burden: What Has the CHIP Ever Done for Cellular Protein Quality Control Mechanism Implicated in Neurodegeneration and Aging?Co-chaperone HSJ1a dually regulates the proteasomal degradation of ataxin-3CHIP regulates AKT/FoxO/Bim signaling in MCF7 and MCF10A cellsAurora Kinase A Promotes AR Degradation via the E3 Ligase CHIP.The E3 Ligase CHIP Mediates p21 Degradation to Maintain Radioresistance.Cotargeting HSP90 and Its Client Proteins for Treatment of Prostate Cancer.Chaperone functions of the E3 ubiquitin ligase CHIP.GSK3β controls epithelial-mesenchymal transition and tumor metastasis by CHIP-mediated degradation of SlugProtein-Protein Interactions Modulate the Docking-Dependent E3-Ubiquitin Ligase Activity of Carboxy-Terminus of Hsc70-Interacting Protein (CHIP)Combining Oncolytic Virotherapy with p53 Tumor Suppressor Gene TherapyCHIP is a novel tumor suppressor in pancreatic cancer through targeting EGFRMDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer.Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2.The role of mutant p53 in human cancer.Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease.Limiting the power of p53 through the ubiquitin proteasome pathway.Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor.Making sense of ubiquitin ligases that regulate p53.Molecular mechanism of mutant p53 stabilization: the role of HSP70 and MDM2.The Unfolded Protein Response, Degradation from Endoplasmic Reticulum and CancerProposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage.Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cellsCancerous inhibitor of PP2A is targeted by natural compound celastrol for degradation in non-small-cell lung cancer.Balance of Yin and Yang: ubiquitylation-mediated regulation of p53 and c-MycSAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis.Laminar flow activation of ERK5 leads to cytoprotective effect via CHIP-mediated p53 ubiquitination in endothelial cellsRegulation of oxidative DNA damage repair by DNA polymerase λ and MutYH by cross-talk of phosphorylation and ubiquitination.Regulation of proto-oncogenic dbl by chaperone-controlled, ubiquitin-mediated degradation.p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction.Reciprocal Regulation of ERα and ERβ Stability and Activity by Diptoindonesin G.CHIP stabilizes amyloid precursor protein via proteasomal degradation and p53-mediated trans-repression of β-secretase.The chaperone-assisted E3 ligase C terminus of Hsc70-interacting protein (CHIP) targets PTEN for proteasomal degradation.
P2860
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P2860
The chaperone-associated ubiquitin ligase CHIP is able to target p53 for proteasomal degradation.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
The chaperone-associated ubiqu ...... 3 for proteasomal degradation.
@en
type
label
The chaperone-associated ubiqu ...... 3 for proteasomal degradation.
@en
prefLabel
The chaperone-associated ubiqu ...... 3 for proteasomal degradation.
@en
P356
P1476
The chaperone-associated ubiqu ...... 3 for proteasomal degradation.
@en
P2093
Claudia Esser
Jörg Höhfeld
P304
27443-27448
P356
10.1074/JBC.M501574200
P407
P577
2005-05-23T00:00:00Z