Configurationally defined phosphorothioate-containing oligoribonucleotides in the study of the mechanism of cleavage of hammerhead ribozymes.
about
Functional identification of catalytic metal ion binding sites within RNA.X-ray crystallographic observation of "in-line" and "adjacent" conformations in a bulged self-cleaving RNA/DNA hybrid.Structure of the U6 RNA intramolecular stem-loop harboring an S(P)-phosphorothioate modificationNMR Localization of Divalent Cations at the Active Site of the Neurospora VS Ribozyme Provides Insights into RNA–Metal-Ion InteractionsThe first step of aminoacylation at the atomic level in histidyl-tRNA synthetaseSpatial organization of protein-RNA interactions in the branch site-3' splice site region during pre-mRNA splicing in yeast.Coordination of divalent metal ions in the active site of poly(A)-specific ribonucleaseChloroplast ribonuclease P does not utilize the ribozyme-type pre-tRNA cleavage mechanismTertiary contacts distant from the active site prime a ribozyme for catalysis.Functional involvement of G8 in the hairpin ribozyme cleavage mechanism.Evaluation of methylphosphonates as analogs for detecting phosphate contacts in RNA-protein complexesRecent advances in the elucidation of the mechanisms of action of ribozymesA Two-Metal-Ion-Mediated Conformational Switching Pathway for HDV Ribozyme ActivationA functional gene discovery in the Fas-mediated pathway to apoptosis by analysis of transiently expressed randomized hybrid-ribozyme librariesA further investigation and reappraisal of the thio effect in the cleavage reaction catalyzed by a hammerhead ribozyme.Helix P4 is a divalent metal ion binding site in the conserved core of the ribonuclease P ribozyme.Comparison of the hammerhead cleavage reactions stimulated by monovalent and divalent cations.Analysis of the cleavage reaction of a trans-acting human hepatitis delta virus ribozyme.Chemical and enzymatic properties of bridging 5'-S-phosphorothioester linkages in DNA.Synthesis and biological activities of a phosphorodithioate analog of 2',5'-oligoadenylate.Nuclease-resistant chimeric ribozymes containing deoxyribonucleotides and phosphorothioate linkages.Ground-state coordination of a catalytic metal to the scissile phosphate of a tertiary-stabilized Hammerhead ribozyme.Enhancement of ribozyme catalytic activity by a contiguous oligodeoxynucleotide (facilitator) and by 2'-O-methylation.A phosphorothioate at the 3' splice-site inhibits the second splicing step in a group I intron.Coupling of fast and slow modes in the reaction pathway of the minimal hammerhead ribozyme cleavage.Observations on catalysis by hammerhead ribozymes are consistent with a two-divalent-metal-ion mechanism.A thermodynamic analysis of the sequence-specific binding of RNA by bacteriophage MS2 coat protein.Minimal and extended hammerheads utilize a similar dynamic reaction mechanism for catalysis.Molecular dynamics study displays near in-line attack conformations in the hammerhead ribozyme self-cleavage reactionHammerhead ribozymes: importance of stem-loop II for activity.Use of intrinsic binding energy for catalysis by an RNA enzymeEvolution of acceptor stem tRNA recognition by class II prolyl-tRNA synthetase.Identification of specific Rp-phosphate oxygens in the tRNA anticodon loop required for ribosomal P-site bindingDiastereomer characterizations of nitroxide-labeled nucleic acids.Function of specific 2'-hydroxyl groups of guanosines in a hammerhead ribozyme probed by 2' modificationsRibonuclease P (RNase P) RNA is converted to a Cd(2+)-ribozyme by a single Rp-phosphorothioate modification in the precursor tRNA at the RNase P cleavage site.Molecular Dynamics Study of Twister Ribozyme: Role of Mg(2+) Ions and the Hydrogen-Bonding Network in the Active Site.Importance of specific purine amino and hydroxyl groups for efficient cleavage by a hammerhead ribozyme.The roles of the conserved pyrimidine bases in hammerhead ribozyme catalysis: evidence for a magnesium ion-binding site.The synthesis of oligoribonucleotides containing O6-methylguanosine: the role of conserved guanosine residues in hammerhead ribozyme cleavage
P2860
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P2860
Configurationally defined phosphorothioate-containing oligoribonucleotides in the study of the mechanism of cleavage of hammerhead ribozymes.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
Configurationally defined phos ...... avage of hammerhead ribozymes.
@en
type
label
Configurationally defined phos ...... avage of hammerhead ribozymes.
@en
prefLabel
Configurationally defined phos ...... avage of hammerhead ribozymes.
@en
P2860
P356
P1476
Configurationally defined phos ...... avage of hammerhead ribozymes.
@en
P2860
P304
P356
10.1093/NAR/19.6.1183
P577
1991-03-01T00:00:00Z