Functional characterization of the 5' flanking region of the BACE gene: identification of a 91 bp fragment involved in basal level of BACE promoter expression.
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Functional activity of the novel Alzheimer's amyloid β-peptide interacting domain (AβID) in the APP and BACE1 promoter sequences and implications in activating apoptotic genes and in amyloidogenesisThe normal and pathologic roles of the Alzheimer's β-secretase, BACE1Metabolic stress modulates Alzheimer's β-secretase gene transcription via SIRT1-PPARγ-PGC-1 in neurons.Beta-secretase: structure, function, and evolution.Beyond the signaling effect role of amyloid-ß42 on the processing of APP, and its clinical implicationsLessons from a BACE1 inhibitor trial: off-site but not off base.Two novel DNA motifs are essential for BACE1 gene transcriptionDifferential regulation of BACE1 expression by oxidative and nitrosative signalsEvidence of a novel mechanism for partial γ-secretase inhibition induced paradoxical increase in secreted amyloid β proteinHypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expressionStructural and functional characterization of H2 haplotype MAPT promoter: unique neurospecific domains and a hypoxia-inducible element would enhance rationally targeted tauopathy research for Alzheimer's disease.Restraint stress and repeated corticotrophin-releasing factor receptor activation in the amygdala both increase amyloid-β precursor protein and amyloid-β peptide but have divergent effects on brain-derived neurotrophic factor and pre-synaptic proteiThe Alzheimer's disease beta-secretase enzyme, BACE1.Lysophosphatidic acid induces increased BACE1 expression and Aβ formation.Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1.Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processingLifespan profiles of Alzheimer's disease-associated genes and products in monkeys and miceThe Basic Biology of BACE1: A Key Therapeutic Target for Alzheimer's Disease.Palmitate induces transcriptional regulation of BACE1 and presenilin by STAT3 in neurons mediated by astrocytesMicroRNA-339-5p down-regulates protein expression of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) in human primary brain cultures and is reduced in brain tissue specimens of Alzheimer disease subjectsNFkappaB-dependent control of BACE1 promoter transactivation by Abeta42.Complex translational regulation of BACE1 involves upstream AUGs and stimulatory elements within the 5' untranslated region.Leaky scanning and reinitiation regulate BACE1 gene expression.Co-localization and distribution of cerebral APP and SP1 and its relationship to amyloidogenesis.
P2860
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P2860
Functional characterization of the 5' flanking region of the BACE gene: identification of a 91 bp fragment involved in basal level of BACE promoter expression.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Functional characterization of ...... l of BACE promoter expression.
@en
type
label
Functional characterization of ...... l of BACE promoter expression.
@en
prefLabel
Functional characterization of ...... l of BACE promoter expression.
@en
P2093
P356
P1433
P1476
Functional characterization of ...... l of BACE promoter expression.
@en
P2093
Debomoy K Lahiri
Kumar Sambamurti
Yuan-Wen Ge
P304
P356
10.1096/FJ.03-1379FJE
P407
P577
2004-04-01T00:00:00Z