Overcoming resistance to gamma-rays in squamous carcinoma cells by poly-drug elevation of ceramide levels.
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Transient alteration of cellular redox buffering before irradiation triggers apoptosis in head and neck carcinoma stem and non-stem cellsAcid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer.Heat shock protein 27 as a new therapeutic target for radiation sensitization of head and neck squamous cell carcinoma.The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis.Interdiction of sphingolipid metabolism to improve standard cancer therapies.Inhibition of ceramide metabolism sensitizes human leukemia cells to inhibition of BCL2-like proteinsp53-independent early and late apoptosis is mediated by ceramide after exposure of tumor cells to photon or carbon ion irradiation.Combinatorial therapies improve the therapeutic efficacy of nanoliposomal ceramide for pancreatic cancer.Recent developments in cancer chemotherapy oriented towards new targets.Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasisMitochondrial ceramide and the induction of apoptosisSphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosisNovel analogs of D-e-MAPP and B13. Part 2: signature effects on bioactive sphingolipids.Novel analogs of D-e-MAPP and B13. Part 1: synthesis and evaluation as potential anticancer agents.Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation.Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapyTargeting sphingolipid metabolism in head and neck cancer: rational therapeutic potentials.Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases.Allylic structures in cancer drugs and body metabolites that control cell life and death.Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse.Cytotoxicities and Quantitative Structure Activity Relationships of B13 Sulfonamides in HT-29 and A549 Cells.Cytotoxic activity and quantitative structure activity relationships of arylpropyl sulfonamides.Role of metabolism in cancer cell radioresistance and radiosensitization methods.
P2860
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P2860
Overcoming resistance to gamma-rays in squamous carcinoma cells by poly-drug elevation of ceramide levels.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Overcoming resistance to gamma ...... elevation of ceramide levels.
@en
type
label
Overcoming resistance to gamma ...... elevation of ceramide levels.
@en
prefLabel
Overcoming resistance to gamma ...... elevation of ceramide levels.
@en
P2093
P2860
P356
P1433
P1476
Overcoming resistance to gamma ...... elevation of ceramide levels.
@en
P2093
Claire Rodriguez-Lafrasse
Clara Bionda
Dominique Ardail
Gersende Alphonse
Marie-Thérèse Aloy
Robert Rousson
P2860
P2888
P304
P356
10.1038/SJ.ONC.1207357
P407
P577
2004-04-01T00:00:00Z
P5875
P6179
1036844348