Cytotoxic T cells learn specificity for self H-2 during differentiation in the thymus. - Wikidata - awgldk - TriplyDB

Cytotoxic T cells learn specificity for self H-2 during differentiation in the thymus.

Cytotoxic T cells learn specificity for self H-2 during differentiation in the thymus.

http://www.wikidata.org/entity/Q40666806

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Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability Ubc9 Is Required for Positive Selection and Late-Stage Maturation of Thymocytes.An analysis of T-cell receptor variable region gene expression in major histocompatibility complex disparate mice.Revisiting thymic positive selection and the mature T cell repertoire for antigen.Purified hematopoietic stem cell grafts induce tolerance to alloantigens and can mediate positive and negative T cell selection Alterations of thymus cortical epithelium and interdigitating dendritic cells but no increase of thymocyte cell death in the early course of simian immunodeficiency virus infection.On 'reactivity' versus 'tolerance'.Autoimmune diseases: immunopathology and etiopathogenesis Class II-positive hematopoietic cells cannot mediate positive selection of CD4+ T lymphocytes in class II-deficient mice Anti-self HLA may be clonally expressed Nature of T-cell macrophage interaction in helper-cell induction in vitro. II. Two stages of T-helper-cell differentiation analyzed in irradiation and allophenic chimeras.A role for elevated H-2 antigen expression in resistance to neoplasia caused by radiation-induced leukemia virus. Enhancement of effective tumor surveillance by killer lymphocytes.Regulation of cytotoxic T-cell reactivity to syngeneic tumors by the thymus.H-2 antigens of the thymus determine lymphocyte specificity.B cell repertoire diversity in athymic mice.Cytotoxic T lymphocyte responses by chimeric thymocytes. Self-recognition is determined early in T cell development.Murine syngeneic mixed lymphocyte response. I. Target antigens are self Ia molecules Differentiation from precursors in athymic nude mouse bone marrow of unusual spontaneously cytolytic cells showing anti-self-H-2 specificity and bearing T cell markers Self-recognition specificity expressed by T cells from nude mice. Absence of detectable Ia-restricted T cells in nude mice that do exhibit self-K/D-restricted T cell responses.Absence of the Lyt-2-,L3T4+ lineage of T cells in mice treated neonatally with anti-I-A correlates with absence of intrathymic I-A-bearing antigen-presenting cell function.Coordinate regulation of the human TAP1 and LMP2 genes from a shared bidirectional promoter.Priming of cytotoxic T lymphocytes by DNA vaccines: requirement for professional antigen presenting cells and evidence for antigen transfer from myocytes.Cell receptors for the mammalian reovirus: reovirus-specific T-cell hybridomas can become persistently infected and undergo autoimmune stimulation.Viral infection causes a shift in the self peptide repertoire presented by human MHC class I molecules.T cell-positive selection uses self-ligand binding strength to optimize repertoire recognition of foreign antigens.Bone marrow-derived thymic antigen-presenting cells determine self-recognition of Ia-restricted T lymphocytes.Mutations that impair a posttranscriptional step in expression of HLA-A and -B antigens.Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice The phenotype of lymphoid cells and thymic epithelium correlates with development of autoimmune insulitis in NOD in equilibrium with C57BL/6 allophenic chimeras.A structural voyage toward an understanding of the MHC-I-restricted immune response: lessons learned and much to be learned.A Phase II Study of Partial and Subtotal Thymectomy for Thymoma (JART02).Intrathymic and extrathymic T cell maturation.The influence of the major histocompatibility complex on the function of T-helper cells in antibody formation.Thymus and lymphohemopoietic cells: their role in T cell maturation in selection of T cells' H-2-restriction-specificity and in H-2 linked Ir gene control.The influence of thymus H-2 antigens on the specificity of maturing killer and helper cells.Production of an H--2-related suppressor factor by a hybrid T-cell line.Comparison of antigen-specific I-region-associated cell interaction factors.T cell selection in the thymus.Maturation of the immune system and immunodeficiency.Impact of thymus on the generation of immunocompetence and diversity of antigen-specific MHC-restricted cytotoxic T-lymphocyte precursors.

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P2860

Cytotoxic T cells learn specificity for self H-2 during differentiation in the thymus.

http://www.wikidata.org/entity/Q40666806

description

1978 nî lūn-bûn

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1978年の論文

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1978年論文

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1978年論文

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1978年論文

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1978年论文

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1978年论文

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1978年论文

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Cytotoxic T cells learn specificity for self H-2 during differentiation in the thymus.

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Cytotoxic T cells learn specificity for self H-2 during differentiation in the thymus.

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Cytotoxic T cells learn specificity for self H-2 during differentiation in the thymus.

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Cytotoxic T cells learn specificity for self H-2 during differentiation in the thymus.

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Callahan GN

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Dennert G

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Klein J

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Zinkernagel RM

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P2860

Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytic choriomeningitis.

H-2 restriction of virus-specific cytotoxicity across the H-2 barrier. Separate effector T-cell specificities are associated with self-H-2 and with the tolerated allogeneic H-2 in chimeras.

Neonatally tolerant mice fail to react against virus-infected tolerated cells.

The generation of killer cells to trinitrophenyl-modified allogeneic targets by lymphocyte populations negatively selected to strong alloantigens.

In a radiation chimaera, host H-2 antigens determine immune responsiveness of donor cytotoxic cells.

Virus and trinitrophenol hapten-specific T-cell-mediated cytotoxicity against H-2 incompatible target cells.

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251-253

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scholarly article

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10.1038/271251A0

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5642

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271

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1978-01-01T00:00:00Z

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1053143499

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304527

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