Beta-hydroxyisovalerylshikonin induces apoptosis in human leukemia cells by inhibiting the activity of a polo-like kinase 1 (PLK1).
about
SAK, a new polo-like kinase, is transcriptionally repressed by p53 and induces apoptosis upon RNAi silencingAnticancer agent shikonin is an incompetent inducer of cancer drug resistanceShikonin inhibits the growth of human prostate cancer cells via modulation of the androgen receptor.Polo-like kinase 1 enhances survival and mutagenesis after genotoxic stress in normal cells through cell cycle checkpoint bypass.Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2.Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin.Polo-like kinase 1 (PLK1) is involved in toll-like receptor (TLR)-mediated TNF-α production in monocytic THP-1 cells.Shikonin and its derivatives: a patent review.Shikonin Inhibits the Proliferation of Human Breast Cancer Cells by Reducing Tumor-Derived Exosomes.Reactive oxygen species-mediated activation of the Akt/ASK1/p38 signaling cascade and p21(Cip1) downregulation are required for shikonin-induced apoptosis.Hinesol, a compound isolated from the essential oils of Atractylodes lancea rhizome, inhibits cell growth and induces apoptosis in human leukemia HL-60 cells.Shikonin Inhibits Tumor Growth in Mice by Suppressing Pyruvate Kinase M2-mediated Aerobic Glycolysis
P2860
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P2860
Beta-hydroxyisovalerylshikonin induces apoptosis in human leukemia cells by inhibiting the activity of a polo-like kinase 1 (PLK1).
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Beta-hydroxyisovalerylshikonin ...... f a polo-like kinase 1 (PLK1).
@en
type
label
Beta-hydroxyisovalerylshikonin ...... f a polo-like kinase 1 (PLK1).
@en
prefLabel
Beta-hydroxyisovalerylshikonin ...... f a polo-like kinase 1 (PLK1).
@en
P2093
P2860
P356
P1433
P1476
Beta-hydroxyisovalerylshikonin ...... of a polo-like kinase 1 (PLK1)
@en
P2093
Ayano Nishida
Kazuyasu Nakaya
Masahiro Asaka
Sachiko Kajimoto
Shigeo Nakajo
Takahiro Hirabayashi
Takeshi Kondo
Yutaka Masuda
P2860
P2888
P304
P356
10.1038/SJ.ONC.1206200
P407
P50
P577
2003-02-01T00:00:00Z
P6179
1046351061