Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1.
about
Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1Centrosome-associated regulators of the G(2)/M checkpoint as targets for cancer therapyCyclin B1-Cdk1 activation continues after centrosome separation to control mitotic progressionA novel RING finger protein, human enhancer of invasion 10, alters mitotic progression through regulation of cyclin B levelsAPC/C(Cdh1) targets brain-specific kinase 2 (BRSK2) for degradation via the ubiquitin-proteasome pathwayMitotic regulation of the human anaphase-promoting complex by phosphorylationMechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complexEarly mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/CDifferential expression, localization and activity of two alternatively spliced isoforms of human APC regulator CDH1Timing of APC/C substrate degradation is determined by fzy/fzr specificity of destruction boxes.Mammalian Cdh1/Fzr mediates its own degradationHuman enhancer of invasion-cluster, a coiled-coil protein required for passage through mitosisMG-132, an inhibitor of proteasomes and calpains, induced inhibition of oocyte maturation and aneuploidy in mouse oocytesAntimitotic drugs in the treatment of cancerFunctional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesisSister chromatid segregation in meiosis II: deprotection through phosphorylationQuantitative framework for ordered degradation of APC/C substrates.Expression of constitutively active CDK1 stabilizes APC-Cdh1 substrates and potentiates premature spindle assembly and checkpoint function in G1 cellsGlobal Phosphoproteomic Mapping of Early Mitotic Exit in Human Cells Identifies Novel Substrate Dephosphorylation MotifsSequential replication-coupled destruction at G1/S ensures genome stability.Cdc20 is critical for meiosis I and fertility of female miceStructural analysis of human Cdc20 supports multisite degron recognition by APC/CSeparase biosensor reveals that cohesin cleavage timing depends on phosphatase PP2A(Cdc55) regulationUnique D box and KEN box sequences limit ubiquitination of Acm1 and promote pseudosubstrate inhibition of the anaphase-promoting complexNuclear localization of the cell cycle regulator CDH1 and its regulation by phosphorylationThe DNA damage response mediator MDC1 directly interacts with the anaphase-promoting complex/cyclosomeLoss of Cdc20 causes a securin-dependent metaphase arrest in two-cell mouse embryosThe APC/C recruits cyclin B1-Cdk1-Cks in prometaphase before D box recognition to control mitotic exitThe HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transitionA Centromere-Signaling Network Underlies the Coordination among Mitotic EventsDose-dependent effects of stable cyclin B1 on progression through mitosis in human cells.Emi1 is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/CPrometaphase APCcdh1 activity prevents non-disjunction in mammalian oocytes.Rapid cycling and precocious termination of G1 phase in cells expressing CDK1AF.Inhibitory phosphorylation of cyclin-dependent kinase 1 as a compensatory mechanism for mitosis exit.Mechanical impulses can control metaphase progression in a mammalian cellCritical differences between isoforms of securin reveal mechanisms of separase regulationSequestration of CDH1 by MAD2L2 prevents premature APC/C activation prior to anaphase onset.Kinetic framework of spindle assembly checkpoint signallingMultiple mechanisms determine the order of APC/C substrate degradation in mitosis.
P2860
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P2860
Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Human securin proteolysis is c ...... m activation by Cdc20 to Cdh1.
@en
type
label
Human securin proteolysis is c ...... m activation by Cdc20 to Cdh1.
@en
prefLabel
Human securin proteolysis is c ...... m activation by Cdc20 to Cdh1.
@en
P2093
P2860
P356
P1476
Human securin proteolysis is c ...... m activation by Cdc20 to Cdh1.
@en
P2093
Anja Hagting
Hartmut C Vodermaier
Irene C Waizenegger
Jan-Michael Peters
P2860
P304
P356
10.1083/JCB.200111001
P407
P577
2002-06-17T00:00:00Z