Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells.
about
Ku regulates the non-homologous end joining pathway choice of DNA double-strand break repair in human somatic cellsDNA ligase III and DNA ligase IV carry out genetically distinct forms of end joining in human somatic cellsDynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4Biochemical evidence for Ku-independent backup pathways of NHEJHomologous Recombination Deficiency: Exploiting the Fundamental Vulnerability of Ovarian CancerHuman LIGIV is synthetically lethal with the loss of Rad54B-dependent recombination and is required for certain chromosome fusion events induced by telomere dysfunctionIgH class switching and translocations use a robust non-classical end-joining pathwayModulation of DNA end joining by nuclear proteinsMDC1 regulates DNA-PK autophosphorylation in response to DNA damageGenome-wide mapping of DNA strand breaksDNA ligases I and III cooperate in alternative non-homologous end-joining in vertebrates53BP1 is required for class switch recombination.De novo mutations in SMCHD1 cause Bosma arhinia microphthalmia syndrome and abrogate nasal development.MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endingsPARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathwaysTargeted engineering of the Caenorhabditis elegans genome following Mos1-triggered chromosomal breaksUntangling the relationships between DNA repair pathways by silencing more than 20 DNA repair genes in human stable clones.Extensive ssDNA end formation at DNA double-strand breaks in non-homologous end-joining deficient cells during the S phaseNumt-mediated double-strand break repair mitigates deletions during primate genome evolutionOrigin-dependent initiation of DNA replication within telomeric sequencesDual roles for DNA polymerase theta in alternative end-joining repair of double-strand breaks in Drosophila.An end-joining repair mechanism in Escherichia coli.Differential role of nonhomologous end joining factors in the generation, DNA damage response, and myeloid differentiation of human induced pluripotent stem cells.Essential factors for incompatible DNA end joining at chromosomal DNA double strand breaks in vivo.Cernunnos influences human immunoglobulin class switch recombination and may be associated with B cell lymphomagenesisThe alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies.A new type of radiosensitive T-B-NK+ severe combined immunodeficiency caused by a LIG4 mutation.Pathway choice in DNA double strand break repair: observations of a balancing act.End-joining repair of double-strand breaks in Drosophila melanogaster is largely DNA ligase IV independent.Lig4 and rad54 are required for repair of DNA double-strand breaks induced by P-element excision in DrosophilaEfficient gene targeting in Drosophila with zinc-finger nucleasesNonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells.A structural model for regulation of NHEJ by DNA-PKcs autophosphorylationKu-dependent and Ku-independent end-joining pathways lead to chromosomal rearrangements during double-strand break repair in Saccharomyces cerevisiae.The Drosophila melanogaster DNA Ligase IV gene plays a crucial role in the repair of radiation-induced DNA double-strand breaks and acts synergistically with Rad54Formation of NHEJ-derived reciprocal chromosomal translocations does not require Ku70.Differential role of DNA-PKcs phosphorylations and kinase activity in radiosensitivity and chromosomal instability.Aberrant V(D)J recombination in ataxia telangiectasia mutated-deficient lymphocytes is dependent on nonhomologous DNA end joining.53BP1 promotes microhomology-mediated end-joining in G1-phase cells.Fidelity of end joining in mammalian episomes and the impact of Metnase on joint processing.
P2860
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P2860
Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Different types of V(D)J recom ...... repair mutant mammalian cells.
@en
type
label
Different types of V(D)J recom ...... repair mutant mammalian cells.
@en
prefLabel
Different types of V(D)J recom ...... repair mutant mammalian cells.
@en
P2093
P1476
Different types of V(D)J recom ...... repair mutant mammalian cells.
@en
P2093
Diana van Heemst
Dik C van Gent
Hennie T Brüggenwirth
Jan H J Hoeijmakers
Malgorzata Z Zdzienicka
Nicole S Verkaik
Rebecca E E Esveldt-van Lange
P304
P356
10.1002/1521-4141(200203)32:3<701::AID-IMMU701>3.0.CO;2-T
P407
P577
2002-03-01T00:00:00Z