A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6.
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Interleukin-6 induces hepcidin expression through STAT3Principles of interleukin (IL)-6-type cytokine signalling and its regulationInterleukin-6-type cytokine signalling through the gp130/Jak/STAT pathwayStructural requirements of the interleukin-6 signal transducer gp130 for its interaction with Janus kinase 1: the receptor is crucial for kinase activationKinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral stateInterferon-alpha-induced phosphorylation and activation of cytosolic phospholipase A2 is required for the formation of interferon-stimulated gene factor threeThe substrates and binding partners of protein kinase CepsilonJak1 kinase is required for cell migrations and anterior specification in zebrafish embryosMitochondrial Stat3, the Need for Design ThinkingTargeted inhibition of STATs and IRFs as a potential treatment strategy in cardiovascular diseaseMarburg Virus Evades Interferon Responses by a Mechanism Distinct from Ebola VirusHuman TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndromeMaking a grade: Sonic Hedgehog signalling and the control of neural cell fateA completely foreign receptor can mediate an interferon-gamma-like response.Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritisn-Butylidenephthalide (BP) maintains stem cell pluripotency by activating Jak2/Stat3 pathway and increases the efficiency of iPS cells generationThe LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activitiesCannabinoid 1 receptor and interleukin-6 receptor together induce integration of protein kinase and transcription factor signaling to trigger neurite outgrowthNovel interactions between NFATc1 (Nuclear Factor of Activated T cells c1) and STAT-3 (Signal Transducer and Activator of Transcription-3) mediate G protein-coupled receptor agonist, thrombin-induced biphasic expression of cyclin D1, with first phasIdentification of YB-1 as a regulator of PTP1B expression: implications for regulation of insulin and cytokine signalingMutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction.Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expressionPlatelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteinsTYK2 kinase activity is required for functional type I interferon responses in vivoRole of cytokine signaling during nervous system developmentBeta interferon and oncostatin M activate Raf-1 and mitogen-activated protein kinase through a JAK1-dependent pathway.Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo.Signal integration and gene induction by a functionally distinct STAT3 phosphoform.The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors.Non-cell-autonomous activation of IL-6/STAT3 signaling mediates FGF19-driven hepatocarcinogenesis.Constitutive activation of signal transducer and activator of transcription 3 regulates expression of vascular endothelial growth factor in human meningioma differentiation.Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling?Mutational switch of an IL-6 response to an interferon-gamma-like response.Identification of amino acid residues of gp130 signal transducer and gp80 alpha receptor subunit that are involved in ligand binding and signaling by human herpesvirus 8-encoded interleukin-6.The ubiquitin ligase TRAF6 negatively regulates the JAK-STAT signaling pathway by binding to STAT3 and mediating its ubiquitinationIFN-λ Inhibits MiR-122 Transcription through a Stat3-HNF4α Inflammatory Feedback Loop in an IFN-α Resistant HCV Cell Culture System.Elucidating the crosstalk mechanism between IFN-gamma and IL-6 via mathematical modelling.What does Stat3 do?The paradigm of IL-6: from basic science to medicineMarburg virus VP40 antagonizes interferon signaling in a species-specific manner.
P2860
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P2860
A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
A major role for the protein t ...... in response to interleukin-6.
@en
type
label
A major role for the protein t ...... in response to interleukin-6.
@en
prefLabel
A major role for the protein t ...... in response to interleukin-6.
@en
P2093
P2860
P1433
P1476
A major role for the protein t ...... y in response to interleukin-6
@en
P2093
B Witthuhn
K Yasukawa
P Heinrich
S Pellegrini
P2860
P304
P356
10.1002/J.1460-2075.1995.TB07128.X
P407
P577
1995-04-01T00:00:00Z