Posttranslational regulation of acid sphingomyelinase in niemann-pick type C1 fibroblasts and free cholesterol-enriched chinese hamster ovary cells.
about
Regulation of sterol transport between membranes and NPC2Analytical Characterization of Methyl-β-Cyclodextrin for Pharmacological Activity to Reduce Lysosomal Cholesterol Accumulation in Niemann-Pick Disease Type C1 Cells.Niemann-Pick C disease and mobilization of lysosomal cholesterol by cyclodextrinImprovement in lipid and protein trafficking in Niemann-Pick C1 cells by correction of a secondary enzyme defect.Niemann-Pick type C disease and intracellular cholesterol trafficking.Glucosylceramidase mass and subcellular localization are modulated by cholesterol in Niemann-Pick disease type C.Consequences of cellular cholesterol accumulation: basic concepts and physiological implicationsAmino acid substitution in NPC1 that abolishes cholesterol binding reproduces phenotype of complete NPC1 deficiency in mice.Pulmonary manifestations in Niemann-Pick type C disease with mutations in NPC2 gene: case report and review of literature.Characterization of secretory sphingomyelinase activity, lipoprotein sphingolipid content and LDL aggregation in ldlr-/- mice fed on a high-fat dietProteomic analysis of mouse models of Niemann-Pick C disease reveals alterations in the steady-state levels of lysosomal proteins within the brain.Identification of Niemann-Pick C1 disease biomarkers through sphingolipid profilingPartial blockage of sterol biosynthesis with a squalene synthase inhibitor in early postnatal Niemann-Pick type C npcnih null mice brains reduces neuronal cholesterol accumulation, abrogates astrogliosis, but may inhibit myelin maturation.Triglyceride alters lysosomal cholesterol ester metabolism in cholesteryl ester-laden macrophage foam cells.Roles and regulation of secretory and lysosomal acid sphingomyelinase.Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases.Complex lipid trafficking in Niemann-Pick disease type C.Endocytic trafficking of sphingomyelin depends on its acyl chain length.Silencing of the mutant SCAP allele accounts for restoration of a normal phenotype in CT60 cells selected for NPC1 expression.A novel role for CRTC2 in hepatic cholesterol synthesis through SREBP-2.Acid sphingomyelinase activity is regulated by membrane lipids and facilitates cholesterol transfer by NPC2.Adaptation of neuronal cells to chronic oxidative stress is associated with altered cholesterol and sphingolipid homeostasis and lysosomal function.Acid sphingomyelinase-deficient macrophages have defective cholesterol trafficking and efflux.A novel cholesterol stain reveals early neuronal cholesterol accumulation in the Niemann-Pick type C1 mouse brain.Sphingomyelinase deficiency (Niemann-Pick disease) in a Hereford calf.
P2860
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P2860
Posttranslational regulation of acid sphingomyelinase in niemann-pick type C1 fibroblasts and free cholesterol-enriched chinese hamster ovary cells.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Posttranslational regulation o ...... d chinese hamster ovary cells.
@en
type
label
Posttranslational regulation o ...... d chinese hamster ovary cells.
@en
prefLabel
Posttranslational regulation o ...... d chinese hamster ovary cells.
@en
P2093
P2860
P356
P1476
Posttranslational regulation o ...... d chinese hamster ovary cells.
@en
P2093
Hubbert ML
Reagan JW Jr
Shelness GS
P2860
P304
38104-38110
P356
10.1074/JBC.M005296200
P407
P577
2000-12-01T00:00:00Z