Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes.
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IgVH genes from different anatomical regions, with different histopathological patterns, of a rheumatoid arthritis patient suggest cyclic re-entry of mature synovial B-cells in the hypermutation processFrequent somatic hypermutation of the 5' noncoding region of the BCL6 gene in B-cell lymphomaFrequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain diseaseRelated Mechanisms of Antibody Somatic Hypermutation and Class Switch RecombinationA Model of Somatic Hypermutation Targeting in Mice Based on High-Throughput Ig Sequencing Data.Analysis of patterns of DNA sequence variation in flanking and coding regions of murine germ-line immunoglobulin heavy-chain variable genes: evolutionary implications.An immunoglobulin mutator that targets G.C base pairs.Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritisDNA polymerase mu, a candidate hypermutase?Neonatal immunity and somatic mutation.Immunoglobulin variable region hypermutation in hybrids derived from a pre-B- and a myeloma cell lineEvolution and the molecular basis of somatic hypermutation of antigen receptor genes.Molecular aspects of somatic hypermutation of immunoglobulin genes.Genesis of the strand-biased signature in somatic hypermutation of rearranged immunoglobulin variable genes.Analysis of somatic mutation in five B cell subsets of human tonsil.A well-differentiated B-cell line is permissive for somatic mutation of a transfected immunoglobulin heavy-chain gene.DNA breaks in hypermutating immunoglobulin genes: evidence for a break-and-repair pathway of somatic hypermutationMalignant B cells and antigenic receptor: necessity or habit?B cell variable genes have evolved their codon usage to focus the targeted patterns of somatic mutation on the complementarity determining regionsDifferential V region mutation of two transfected Ig genes and their interaction in cultured B cell linesThe Ig mutator is dependent on the presence, position, and orientation of the large intron enhancer.Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation.On the molecular mechanism of somatic hypermutation of rearranged immunoglobulin genes.Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions.Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice.Induction of Ig somatic hypermutation and class switching in a human monoclonal IgM+ IgD+ B cell line in vitro: definition of the requirements and modalities of hypermutation.Tracing the development of single memory-lineage B cells in a highly defined immune response.The transcriptional promoter regulates hypermutation of the antibody heavy chain locus.Analysis of somatic hypermutation in mouse Peyer's patches using immunoglobulin kappa light-chain transgenesSomatic hypermutation of the new antigen receptor gene (NAR) in the nurse shark does not generate the repertoire: possible role in antigen-driven reactions in the absence of germinal centersSequence dependent hypermutation of the immunoglobulin heavy chain in cultured B cells.Immunogenetic characteristics of immunoglobulin E in allergic disease.Lupus-specific antibodies reveal an altered pattern of somatic mutationThe challenge of the microenvironment in B-cell lymphomas.Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody GenesClonally related IgE and IgG4 transcripts in blood lymphocytes of patients with asthma reveal differing patterns of somatic mutation.Analysis of immunoglobulin E VH transcripts in a bronchial biopsy of an asthmatic patient confirms bias towards VH5, and indicates local clonal expansion, somatic mutation and isotype switch events.Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice.Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID.Overexpression of human DNA polymerase mu (Pol mu) in a Burkitt's lymphoma cell line affects the somatic hypermutation rate.
P2860
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P2860
Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Discriminating intrinsic and a ...... ots in immunoglobulin V genes.
@en
type
label
Discriminating intrinsic and a ...... ots in immunoglobulin V genes.
@en
prefLabel
Discriminating intrinsic and a ...... ots in immunoglobulin V genes.
@en
P2093
P1433
P1476
Discriminating intrinsic and a ...... ots in immunoglobulin V genes.
@en
P2093
C Milstein
M S Neuberger
P304
P356
10.1016/0167-5699(93)90144-A
P577
1993-08-01T00:00:00Z