Domain-specific interaction with the I kappa B kinase (IKK)regulatory subunit IKK gamma is an essential step in tax-mediated activation of IKK.
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The HTLV-1 Tax interactomevCLAP, a caspase-recruitment domain-containing protein of equine Herpesvirus-2, persistently activates the Ikappa B kinases through oligomerization of IKKgammaNonstructural 5A protein of hepatitis C virus modulates tumor necrosis factor alpha-stimulated nuclear factor kappa B activationThe inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosisA novel X-linked disorder of immune deficiency and hypohidrotic ectodermal dysplasia is allelic to incontinentia pigmenti and due to mutations in IKK-gamma (NEMO)Viruses associated with human cancerNF-kappaB activation: Tax sumoylation is out, but what about Tax ubiquitination?A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alphaNEMO trimerizes through its coiled-coil C-terminal domainProtein profile of tax-associated complexesHTLV-1 Tax Functions as a Ubiquitin E3 Ligase for Direct IKK Activation via Synthesis of Mixed-Linkage Polyubiquitin ChainsSegregation of NF-kappaB activation through NEMO/IKKgamma by Tax and TNFalpha: implications for stimulus-specific interruption of oncogenic signalingHuman T-cell lymphotropic virus type 1 Tax represses c-Myb-dependent transcription through activation of the NF-kappaB pathway and modulation of coactivator usage.Exclusive ubiquitination and sumoylation on overlapping lysine residues mediate NF-kappaB activation by the human T-cell leukemia virus tax oncoprotein.Stimulation of IKK-gamma oligomerization by the human T-cell leukemia virus oncoprotein Tax.Molecular pathways in virus-induced cytokine production.Epstein-Barr latent membrane protein 1 transformation site 2 activates NF-kappaB in the absence of NF-kappaB essential modifier residues 133-224 or 373-419.Recent advances in understanding NF-kappaB regulation.An alternative splice product of IkappaB kinase (IKKgamma), IKKgamma-delta, differentially mediates cytokine and human T-cell leukemia virus type 1 tax-induced NF-kappaB activation.Genotoxic stress and cellular stress alter the subcellular distribution of human T-cell leukemia virus type 1 tax through a CRM1-dependent mechanismRole of post-translational modifications of HTLV-1 Tax in NF-κB activation.Versatile reporter systems show that transactivation by human T-cell leukemia virus type 1 Tax occurs independently of chromatin remodeling factor BRG1.Kaposi's sarcoma-associated herpesvirus vFLIP and human T cell lymphotropic virus type 1 Tax oncogenic proteins activate IkappaB kinase subunit gamma by different mechanisms independent of the physiological cytokine-induced pathwaysHuman T-cell lymphotropic virus: a model of NF-κB-associated tumorigenesisMutual regulation between deubiquitinase CYLD and retroviral oncoprotein TaxNF-κB and cancer: a paradigm of Yin-Yang.Move or die: the fate of the Tax oncoprotein of HTLV-1.Endoproteolytic processing of C-terminally truncated NF-kappaB2 precursors at kappaB-containing promotersHTLV-1 Tax mutants that do not induce G1 arrest are disabled in activating the anaphase promoting complex.The tumor suppressor gene WWOX links the canonical and noncanonical NF-κB pathways in HTLV-I Tax-mediated tumorigenesisTranscriptional and post-transcriptional gene regulation of HTLV-1.Activation of NF-kappaB by HTLV-I and implications for cell transformation.The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation.HTLV tax: a fascinating multifunctional co-regulator of viral and cellular pathwaysUbiquitination of HTLV-I Tax in response to DNA damage regulates nuclear complex formation and nuclear export.Human T-cell leukemia virus type 1 tax attenuates the ATM-mediated cellular DNA damage response.Distinct Activation Mechanisms of NF-κB Regulator Inhibitor of NF-κB Kinase (IKK) by Isoforms of the Cell Death Regulator Cellular FLICE-like Inhibitory Protein (cFLIP).PDLIM2 suppresses human T-cell leukemia virus type I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradationNF-κB as a target for oncogenic viruses.Animal models on HTLV-1 and related viruses: what did we learn?
P2860
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P2860
Domain-specific interaction with the I kappa B kinase (IKK)regulatory subunit IKK gamma is an essential step in tax-mediated activation of IKK.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Domain-specific interaction wi ...... ax-mediated activation of IKK.
@en
type
label
Domain-specific interaction wi ...... ax-mediated activation of IKK.
@en
prefLabel
Domain-specific interaction wi ...... ax-mediated activation of IKK.
@en
P2093
P2860
P356
P1476
Domain-specific interaction wi ...... ax-mediated activation of IKK.
@en
P2093
P2860
P304
34060-34067
P356
10.1074/JBC.M002970200
P407
P577
2000-11-01T00:00:00Z