High-level expression of active HIV-1 integrase from a synthetic gene in human cells.
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LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cellsLEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexesEarly steps of retrovirus replicative cycleHIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cellsSolution structure of the HIV-1 integrase-binding domain in LEDGF/p75Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integraseConsensus HIV-1 FSU-A integrase gene variants electroporated into mice induce polyfunctional antigen-specific CD4+ and CD8+ T cellsDNA-Dependent protein kinase is not required for efficient lentivirus integrationIntegrase-specific enhancement and suppression of retroviral DNA integration by compacted chromatin structure in vitroInhibition of early steps of HIV-1 replication by SNF5/Ini1.Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication.The SET complex acts as a barrier to autointegration of HIV-1Sensitivity of cancer cells to truncated diphtheria toxin.GCN2 phosphorylates HIV-1 integrase and decreases HIV-1 replication by limiting viral integration.Genetic analyses of DNA-binding mutants in the catalytic core domain of human immunodeficiency virus type 1 integrase.Infection of lymphoid cells by integration-defective human immunodeficiency virus type 1 increases de novo methylationStructural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.Purification and characterization of HIV-human protein complexes.Impairment of human immunodeficiency virus type-1 integrase SUMOylation correlates with an early replication defect.Site-directed transposon integration in human cells.Integrase, LEDGF/p75 and HIV replication.Multimodal mechanism of action of allosteric HIV-1 integrase inhibitors.Inhibitors of the interactions between HIV-1 IN and the cofactor LEDGF/p75.The Interaction Between Lentiviral Integrase and LEDGF: Structural and Functional InsightsThe interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding.Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication.LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro.Incorporation of aptamers in the terminal loop of shRNAs yields an effective and novel combinatorial targeting strategy.Y-box-binding protein 1 supports the early and late steps of HIV replication
P2860
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P2860
High-level expression of active HIV-1 integrase from a synthetic gene in human cells.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
High-level expression of active HIV-1 integrase from a synthetic gene in human cells.
@en
type
label
High-level expression of active HIV-1 integrase from a synthetic gene in human cells.
@en
prefLabel
High-level expression of active HIV-1 integrase from a synthetic gene in human cells.
@en
P2093
P356
P1433
P1476
High-level expression of active HIV-1 integrase from a synthetic gene in human cells.
@en
P2093
P304
P356
10.1096/FJ.14.10.1389
P407
P577
2000-07-01T00:00:00Z