LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro.
about
Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2)Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressorRetroviral intasome assembly and inhibition of DNA strand transferVirological and cellular roles of the transcriptional coactivator LEDGF/p75Transcriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activityLEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integrationStructural basis for functional tetramerization of lentiviral integraseEmbryonic Lethality Due to Arrested Cardiac Development in Psip1/Hdgfrp2 Double-Deficient MiceFunctional and structural characterization of the integrase from the prototype foamy virusA Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75Crystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding siteMolecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.Crystal structures of catalytic core domain of BIV integrase: implications for the interaction between integrase and target DNAStructural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572)Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturationMultimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase InhibitorsRetroviral integration: Site matters: Mechanisms and consequences of retroviral integration site selectionLEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactorsBiochemical characterization of novel retroviral integrase proteinsNon-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cellsRetroviral DNA IntegrationThermodynamic instability of viral proteins is a pathogen-associated molecular pattern targeted by human defensinsStructural and sequencing analysis of local target DNA recognition by MLV integrase.Biochemical and virological analysis of the 18-residue C-terminal tail of HIV-1 integrase.LEDGF dominant interference proteins demonstrate prenuclear exposure of HIV-1 integrase and synergize with LEDGF depletion to destroy viral infectivityCharacterization of LEDGF/p75 genetic variants and association with HIV-1 disease progression.HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor.Structural basis for HIV-1 DNA integration in the human genome, role of the LEDGF/P75 cofactorVirus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting.The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication.Mass spectrometry-based footprinting of protein-protein interactionsHost cell factors in HIV replication: meta-analysis of genome-wide studies.The requirement for cellular transportin 3 (TNPO3 or TRN-SR2) during infection maps to human immunodeficiency virus type 1 capsid and not integrase.LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin.Structural basis for spumavirus GAG tethering to chromatinThe HIV-1 integrase α4-helix involved in LTR-DNA recognition is also a highly antigenic peptide elementLEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINsMolecular mechanisms of retroviral integration site selection.Integrase-mediated spacer acquisition during CRISPR-Cas adaptive immunity.
P2860
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P2860
LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
LEDGF/p75 interacts with diver ...... r enzymatic activity in vitro.
@en
type
label
LEDGF/p75 interacts with diver ...... r enzymatic activity in vitro.
@en
prefLabel
LEDGF/p75 interacts with diver ...... r enzymatic activity in vitro.
@en
P2860
P356
P1476
LEDGF/p75 interacts with diver ...... r enzymatic activity in vitro.
@en
P2093
Peter Cherepanov
P2860
P304
P356
10.1093/NAR/GKL885
P577
2006-12-07T00:00:00Z