Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus.
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Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell developmentConditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesisCux/CDP homeoprotein is a component of NF-muNR and represses the immunoglobulin heavy chain intronic enhancer by antagonizing the bright transcription activatorCD4+CD25+ regulatory T cells in autoimmune arthritis.Elucidation of IgH intronic enhancer functions via germ-line deletionOrdered assembly of the V(D)J synaptic complex ensures accurate recombinationV(D)J recombination frequency is affected by the sequence interposed between a pair of recombination signals: sequence comparison reveals a putative recombinational enhancer element.Identification of 3' alpha-hs4, a novel Ig heavy chain enhancer element regulated at multiple stages of B cell differentiation.The center of accessibility: Dβ control of V(D)J recombinationSequences affecting the V(D)J recombinational activity of the IgH intronic enhancer in a transgenic substrate.Insertion of an imprinted insulator into the IgH locus reveals developmentally regulated, transcription-dependent control of V(D)J recombination.Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions.Cis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus.Kappa chain monoallelic demethylation and the establishment of allelic exclusion.Enhancer control of V(D)J recombination at the TCRbeta locus: differential effects on DNA cleavage and joining.Dynamic changes in binding of immunoglobulin heavy chain 3' regulatory region to protein factors during class switching.Comparison of identical and functional Igh alleles reveals a nonessential role for Eμ in somatic hypermutation and class-switch recombinationHerpes simplex virus type 1 DNA replication is specifically required for high-frequency homologous recombination between repeated sequences.Critical roles of the immunoglobulin intronic enhancers in maintaining the sequential rearrangement of IgH and Igk loci.Chromosomal position of a VH gene segment determines its activation and inactivation as a substrate for V(D)J recombination.Temporal and lineage-specific control of T cell receptor alpha/delta gene rearrangement by T cell receptor alpha and delta enhancers.Differential activation of transcription versus recombination of transgenic T cell receptor beta variable region gene segments in B and T lineage cellsRegulation of T cell receptor delta gene rearrangement by c-Myb.Domains of the TCR beta-chain required for early thymocyte development.Insertion of phosphoglycerine kinase (PGK)-neo 5' of Jlambda1 dramatically enhances VJlambda1 rearrangementInduction of a diverse T cell receptor gamma/delta repertoire by the helix-loop-helix proteins E2A and HEB in nonlymphoid cells.Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers.The V(D)J recombinational and transcriptional activities of the immunoglobulin heavy-chain intronic enhancer can be mediated through distinct protein-binding sites in a transgenic substratePrecise alignment of sites required for mu enhancer activation in B cells.The absence of the transcription activator TFE3 impairs activation of B cells in vivo.Enhancer control of local accessibility to V(D)J recombinase.B cell development and immunoglobulin transcription in Oct-1-deficient mice.Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility.A role for the IgH intronic enhancer E mu in enforcing allelic exclusion.V(D)J recombination is not activated by demethylation of the kappa locusTranscription of a productively rearranged Ig VDJC alpha does not require the presence of HS4 in the IgH 3' regulatory regionIn a model of immunoglobulin heavy-chain (IGH)/MYC translocation, the Igh 3' regulatory region induces MYC expression at the immature stage of B cell development.Immunoglobulin gene transcription ceases upon deletion of a distant enhancer.The dynamic architectural and epigenetic nuclear landscape: developing the genomic almanac of biology and disease.Expression of the (recombinant) endogenous immunoglobulin heavy-chain locus requires the intronic matrix attachment regions.
P2860
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P2860
Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh
1993年學術文章
@zh-hant
name
Mutations of the intronic IgH ...... accessibility of the JH locus.
@en
type
label
Mutations of the intronic IgH ...... accessibility of the JH locus.
@en
prefLabel
Mutations of the intronic IgH ...... accessibility of the JH locus.
@en
P2093
P2860
P1433
P1476
Mutations of the intronic IgH ...... accessibility of the JH locus
@en
P2093
P2860
P304
P356
10.1002/J.1460-2075.1993.TB06152.X
P407
P577
1993-12-01T00:00:00Z