Premature structural changes at replication origins in a yeast minichromosome maintenance (MCM) mutant.
about
Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensingMini-chromosome maintenance complexes form a filament to remodel DNA structure and topologyThe B2 element of the Saccharomyces cerevisiae ARS1 origin of replication requires specific sequences to facilitate pre-RC formationThe mcm5-bob1 bypass of Cdc7p/Dbf4p in DNA replication depends on both Cdk1-independent and Cdk1-dependent steps in Saccharomyces cerevisiae.Two mcm3 mutations affect different steps in the initiation of DNA replication.Evidence that the pre-mRNA splicing factor Clf1p plays a role in DNA replication in Saccharomyces cerevisiae.How MCM loading and spreading specify eukaryotic DNA replication initiation sitesTwo heads are better than one: regulation of DNA replication by hexameric helicasesThe Dbf4-Cdc7 kinase promotes Mcm2-7 ring opening to allow for single-stranded DNA extrusion and helicase assembly.Drosophila minichromosome maintenance 6 is required for chorion gene amplification and genomic replication.Strong minor groove base conservation in sequence logos implies DNA distortion or base flipping during replication and transcription initiation.The hexameric eukaryotic MCM helicase: building symmetry from nonidentical parts.The Cdc7/Dbf4 protein kinase: target of the S phase checkpoint?Control of DNA replication licensing in a cell cycle.Cdc7 kinase complex: a key regulator in the initiation of DNA replication.A Dbf4p BRCA1 C-terminal-like domain required for the response to replication fork arrest in budding yeast.Dpb11 protein helps control assembly of the Cdc45·Mcm2-7·GINS replication fork helicase.Eukaryotic MCM proteins: beyond replication initiation.Structural changes in Mcm5 protein bypass Cdc7-Dbf4 function and reduce replication origin efficiency in Saccharomyces cerevisiae.Functional conservation of beta-hairpin DNA binding domains in the Mcm protein of Methanobacterium thermoautotrophicum and the Mcm5 protein of Saccharomyces cerevisiae.Cryo-electron microscopy reveals a novel DNA-binding site on the MCM helicase.Cell cycle regulation of DNA replication.Insights into the Initiation of Eukaryotic DNA Replication.The Mcm complex: unwinding the mechanism of a replicative helicase.Budding yeast Dbf4 sequences required for Cdc7 kinase activation and identification of a functional relationship between the Dbf4 and Rev1 BRCT domainsDnaA, ORC, and Cdc6: similarity beyond the domains of life and diversity.Multiple pathways can bypass the essential role of fission yeast Hsk1 kinase in DNA replication initiation.Selective bypass of a lagging strand roadblock by the eukaryotic replicative DNA helicase.A novel intermediate in initiation complex assembly for fission yeast DNA replication.A mutation in Dbf4 motif M impairs interactions with DNA replication factors and confers increased resistance to genotoxic agents.Origin single-stranded DNA releases Sld3 protein from the Mcm2-7 complex, allowing the GINS tetramer to bind the Mcm2-7 complex.Xenopus Drf1, a regulator of Cdc7, displays checkpoint-dependent accumulation on chromatin during an S-phase arrest.Evidence for sequential action of cdc7 and cdk2 protein kinases during initiation of DNA replication in Xenopus egg extracts.Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing
P2860
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P2860
Premature structural changes at replication origins in a yeast minichromosome maintenance (MCM) mutant.
description
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name
Premature structural changes a ...... some maintenance (MCM) mutant.
@en
type
label
Premature structural changes a ...... some maintenance (MCM) mutant.
@en
prefLabel
Premature structural changes a ...... some maintenance (MCM) mutant.
@en
P2093
P2860
P356
P1476
Premature structural changes a ...... some maintenance (MCM) mutant.
@en
P2093
P2860
P304
18011-18021
P356
10.1074/JBC.M909787199
P407
P577
2000-06-01T00:00:00Z