Roles of PRP8 protein in the assembly of splicing complexes.
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The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 proteinHuman step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicingHuman homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicingThe structure and function of proline-rich regions in proteinsPrp8 protein: at the heart of the spliceosomeThe canonical GU dinucleotide at the 5' splice site is recognized by p220 of the U5 snRNP within the spliceosomeThe human Prp8 protein is a component of both U2- and U12-dependent spliceosomesCharacterization of U6 snRNA-protein interactions.Evidence for a Prp24 binding site in U6 snRNA and in a putative intermediate in the annealing of U6 and U4 snRNAsA complementation method for functional analysis of mammalian genesStructure and function of an RNase H domain at the heart of the spliceosomeA conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligationPrp31p promotes the association of the U4/U6 x U5 tri-snRNP with prespliceosomes to form spliceosomes in Saccharomyces cerevisiae.Evidence for a role of Sky1p-mediated phosphorylation in 3' splice site recognition involving both Prp8 and Prp17/Slu4.Assembly of Snu114 into U5 snRNP requires Prp8 and a functional GTPase domain.Yeast ortholog of the Drosophila crooked neck protein promotes spliceosome assembly through stable U4/U6.U5 snRNP addition.Progression through the spliceosome cycle requires Prp38p function for U4/U6 snRNA dissociationSubunits of the Saccharomyces cerevisiae signal recognition particle required for its functional expression.Evidence that the pre-mRNA splicing factor Clf1p plays a role in DNA replication in Saccharomyces cerevisiae.Genetic analysis reveals a role for the C terminus of the Saccharomyces cerevisiae GTPase Snu114 during spliceosome activationFunctional interactions between Prp8, Prp18, Slu7, and U5 snRNA during the second step of pre-mRNA splicing.The biochemical defects of prp4-1 and prp6-1 yeast splicing mutants reveal that the PRP6 protein is required for the accumulation of the [U4/U6.U5] tri-snRNP.Extragenic suppressors of Saccharomyces cerevisiae prp4 mutations identify a negative regulator of PRP genesConvergent transcripts of the yeast PRP38-SMD1 locus encode two essential splicing factors, including the D1 core polypeptide of small nuclear ribonucleoprotein particlesGenetic interactions with CLF1 identify additional pre-mRNA splicing factors and a link between activators of yeast vesicular transport and splicing.Mutagenesis of the yeast gene PRP8 reveals domains governing the specificity and fidelity of 3' splice site selection.A tertiary interaction detected in a human U2-U6 snRNA complex assembled in vitro resembles a genetically proven interaction in yeast.The oligonucleotide binding (OB)-fold domain of KREPA4 is essential for stable incorporation into editosomesUbiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p.The PRP31 gene encodes a novel protein required for pre-mRNA splicing in Saccharomyces cerevisiae.Suppressors of a cold-sensitive mutation in yeast U4 RNA define five domains in the splicing factor Prp8 that influence spliceosome activation.The budding yeast U5 snRNP Prp8 is a highly conserved protein which links RNA splicing with cell cycle progression.Factors required for the binding of reassembled yeast kinetochores to microtubules in vitro.Extensive interactions of PRP8 protein with the 5' and 3' splice sites during splicing suggest a role in stabilization of exon alignment by U5 snRNA.Interaction of the yeast splicing factor PRP8 with substrate RNA during both steps of splicing.SLU7 and a novel activity, SSF1, act during the PRP16-dependent step of yeast pre-mRNA splicing.Functional contacts with a range of splicing proteins suggest a central role for Brr2p in the dynamic control of the order of events in spliceosomes of Saccharomyces cerevisiae.Analysis of synthetic lethality reveals genetic interactions between the GTPase Snu114p and snRNAs in the catalytic core of the Saccharomyces cerevisiae spliceosome.Trans mRNA splicing in trypanosomes: cloning and analysis of a PRP8-homologous gene from Trypanosoma brucei provides evidence for a U5-analogous RNPDHX15 promotes prostate cancer progression by stimulating Siah2-mediated ubiquitination of androgen receptor.
P2860
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P2860
Roles of PRP8 protein in the assembly of splicing complexes.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Roles of PRP8 protein in the assembly of splicing complexes.
@en
type
label
Roles of PRP8 protein in the assembly of splicing complexes.
@en
prefLabel
Roles of PRP8 protein in the assembly of splicing complexes.
@en
P2860
P1433
P1476
Roles of PRP8 protein in the assembly of splicing complexes.
@en
P2093
P2860
P304
P407
P577
1992-10-01T00:00:00Z