Are changes in integrin affinity and conformation overemphasized?
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Oligomerization of the integrin alphaIIbbeta3: roles of the transmembrane and cytoplasmic domainsCoordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeletonMegakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling.A novel function for the Tec family tyrosine kinase Itk in activation of beta 1 integrins by the T-cell receptorType 1 fimbrial adhesin FimH elicits an immune response that enhances cell adhesion of Escherichia coliGreen fluorescent protein (GFP) tagged to the cytoplasmic tail of alphaIIb or beta3 allows the expression of a fully functional integrin alphaIIb(beta3): effect of beta3GFP on alphaIIb(beta3) ligand bindingThe immune dysregulatory compound mercuric chloride induces integrin-mediated T-lymphocyte adhesionActivation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignmentIntegrin leukocyte function-associated antigen-1-mediated cell binding can be activated by clustering of membrane raftsThe oligodendrocyte precursor mitogen PDGF stimulates proliferation by activation of alpha(v)beta3 integrins.RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activationStructural basis of integrin regulation and signalingPrimary megakaryocytes reveal a role for transcription factor NF-E2 in integrin alpha IIb beta 3 signalingEvidence that distinct states of the integrin alpha6beta1 interact with laminin and an ADAM.Extracellular protein disulfide isomerase regulates ligand-binding activity of αMβ2 integrin and neutrophil recruitment during vascular inflammationThe LG3 module of laminin-5 harbors a binding site for integrin alpha3beta1 that promotes cell adhesion, spreading, and migration.The molecular adapter SLP-76 relays signals from platelet integrin alphaIIbbeta3 to the actin cytoskeleton.Quantitative analysis of platelet alpha v beta 3 binding to osteopontin using laser tweezers.Stepped changes of monovalent ligand-binding force during ligand-induced clustering of integrin alphaIIB beta3.Recreation of the terminal events in physiological integrin activation.Mechanisms and consequences of phagocyte adhesion to endothelium.Rac regulates integrin-mediated spreading and increased adhesion of T lymphocytes.Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase.Leukocyte-endothelial interactions in inflammation.Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering.Definition of EGF-like, closely interacting modules that bear activation epitopes in integrin beta subunits.The final steps of integrin activation: the end gameThe GTPase Rap1 regulates phorbol 12-myristate 13-acetate-stimulated but not ligand-induced beta 1 integrin-dependent leukocyte adhesion.Anthrax toxin receptor 1/tumor endothelial marker 8: mutation of conserved inserted domain residues overrides cytosolic control of protective antigen bindingFRET detection of cellular alpha4-integrin conformational activation.Aggregatibacter actinomycetemcomitans leukotoxin (LtxA; Leukothera) induces cofilin dephosphorylation and actin depolymerization during killing of malignant monocytes.An isolated, surface-expressed I domain of the integrin alphaLbeta2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond.Fc receptor inside-out signaling and possible impact on antibody therapy.Molecular pathway for cancer metastasis to bone.Probabilistic modeling of rosette formation.Role of integrins in regulating epidermal adhesion, growth and differentiation.Rapid leukocyte integrin activation by chemokines.Genetic analysis of integrin activation in T lymphocytes.AL-57, a ligand-mimetic antibody to integrin LFA-1, reveals chemokine-induced affinity up-regulation in lymphocytes.Organization of the integrin LFA-1 in nanoclusters regulates its activity.
P2860
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P2860
Are changes in integrin affinity and conformation overemphasized?
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Are changes in integrin affinity and conformation overemphasized?
@en
type
label
Are changes in integrin affinity and conformation overemphasized?
@en
prefLabel
Are changes in integrin affinity and conformation overemphasized?
@en
P1476
Are changes in integrin affinity and conformation overemphasized?
@en
P2093
P356
10.1016/S0968-0004(97)01141-9
P577
1998-01-01T00:00:00Z