Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation.
about
p31comet blocks Mad2 activation through structural mimicryPharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damageShugoshin is a Mad1/Cdc20-like interactor of Mad2Mechanism of ubiquitin-chain formation by the human anaphase-promoting complexA centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neuronsIdentification of a physiological E2 module for the human anaphase-promoting complexAPC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachmentFcp1-dependent dephosphorylation is required for M-phase-promoting factor inactivation at mitosis exitTwo different mitotic checkpoint inhibitors of the anaphase-promoting complex/cyclosome antagonize the action of the activator Cdc20The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction.The multifaceted roles of the HORMA domain in cellular signalingK11-linked ubiquitin chains as novel regulators of cell divisionMitotic and mitogenic Wnt signallingStructure of the mitotic checkpoint complexCryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin LigationThe APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation.Cdk1 promotes kinetochore bi-orientation and regulates Cdc20 expression during recovery from spindle checkpoint arrestSpatiotemporal regulation of the anaphase-promoting complex in mitosisTranscriptional control of mitosis: deregulation and cancerIn-silico modeling of the mitotic spindle assembly checkpointUSP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesisUSP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1Overexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemiaGenetic analysis of the spindle checkpoint genes san-1, mdf-2, bub-3 and the CENP-F homologues hcp-1 and hcp-2 in Caenorhabditis elegans.Microtubule-dependent regulation of mitotic protein degradation.Kinetic framework of spindle assembly checkpoint signallingMitotic catenation is monitored and resolved by a PKCε-regulated pathwayDeregulation of Rb-E2F1 axis causes chromosomal instability by engaging the transactivation function of Cdc20-anaphase-promoting complex/cyclosome.Molecular basis of APC/C regulation by the spindle assembly checkpoint.Individual retinal progenitor cells display extensive heterogeneity of gene expression.The influence of catalysis on mad2 activation dynamics.Transcriptome analysis reveals potential mechanisms underlying differential heart development in fast- and slow-growing broilers under heat stress.UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complexOverexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation.Enhanced protein degradation by branched ubiquitin chains.RIZ1 negatively regulates ubiquitin-conjugating enzyme E2C/UbcH10 via targeting c-Myc in meningioma.ATP is required for the release of the anaphase-promoting complex/cyclosome from inhibition by the mitotic checkpointRegulation of APC/C activators in mitosis and meiosis.APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction.Mitotic chromosomal instability and cancer: mouse modelling of the human disease.
P2860
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P2860
Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation.
@en
type
label
Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation.
@en
prefLabel
Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation.
@en
P2093
P356
P1433
P1476
Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation.
@en
P2093
M W Kirschner
W A Margansky
P2888
P304
P356
10.1038/NATURE05734
P407
P577
2007-04-01T00:00:00Z
P6179
1028946343