Purification of native p94, a muscle-specific calpain, and characterization of its autolysis
about
Calpain 3 is a rapid-action, unidirectional proteolytic switch central to muscle remodelingA new pathway encompassing calpain 3 and its newly identified substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-κB pathway in skeletal muscleNovel variants of muscle calpain 3 identified in human melanoma cells: cisplatin-induced changes in vitro and differential expression in melanocytic lesionsMultiple molecular interactions implicate the connectin/titin N2A region as a modulating scaffold for p94/calpain 3 activity in skeletal muscleThe atypical calpains: evolutionary analyses and roles in Caenorhabditis elegans cellular degenerationCrystal structure of calpain-3 penta-EF-hand (PEF) domain - a homodimerized PEF family member with calcium bound at the fifth EF-handGlucose regulates protein catabolism in ras-transformed fibroblasts through a lysosomal-dependent proteolytic pathwayCharacterization and regulation of lens-specific calpain Lp82Endogenous calpain-3 activation is primarily governed by small increases in resting cytoplasmic [Ca2+] and is not dependent on stretchExpression and functional characteristics of calpain 3 isoforms generated through tissue-specific transcriptional and posttranscriptional eventsA New Insight into the Role of Calpains in Post-mortem Meat Tenderization in Domestic Animals: A review.Stable expression of calpain 3 from a muscle transgene in vivo: immature muscle in transgenic mice suggests a role for calpain 3 in muscle maturation.Comprehensive survey of p94/calpain 3 substrates by comparative proteomics--possible regulation of protein synthesis by p94.Suppressed disassembly of autolyzing p94/CAPN3 by N2A connectin/titin in a genetic reporter system.The N- and C-terminal autolytic fragments of CAPN3/p94/calpain-3 restore proteolytic activity by intermolecular complementation.Autolytic activation of calpain 3 proteinase is facilitated by calmodulin proteinRegulation of the M-cadherin-beta-catenin complex by calpain 3 during terminal stages of myogenic differentiationPathogenity of some limb girdle muscular dystrophy mutations can result from reduced anchorage to myofibrils and altered stability of calpain 3.Loss of calpain-3 autocatalytic activity in LGMD2A patients with normal protein expression.Calpain 3: a key regulator of the sarcomere?Calpain 3, the "gatekeeper" of proper sarcomere assembly, turnover and maintenance.Role of calpains in the injury-induced dysfunction and degeneration of the mammalian axon.mu-Calpain and calpain-3 are not autolyzed with exhaustive exercise in humans.Mutations in calpain 3 associated with limb girdle muscular dystrophy: analysis by molecular modeling and by mutation in m-calpain.Calpain 3 is activated through autolysis within the active site and lyses sarcomeric and sarcolemmal componentsCalpain-dependent proteolysis of merlin occurs by oxidative stress in meningiomas: a novel hypothesis of tumorigenesis.PLEIAD/SIMC1/C5orf25, a novel autolysis regulator for a skeletal-muscle-specific calpain, CAPN3, scaffolds a CAPN3 substrate, CTBP1.RGS4 is arginylated and degraded by the N-end rule pathway in vitro.Expression, partial purification and functional properties of themuscle-specific calpain isoform p94.Homodimerization of calpain 3 penta-EF-hand domain.Characterization of a new p94-like calpain form in human lymphocytes.Molecular adaptations of neuromuscular disease-associated proteins in response to eccentric exercise in human skeletal muscle.Insertion sequence 1 of muscle-specific calpain, p94, acts as an internal propeptide.Characterization of the expression profile of calpain-3 (CAPN3) gene in chicken.Disruption of excitation-contraction coupling and titin by endogenous Ca2+-activated proteases in toad muscle fibres.Calpain 3 participates in sarcomere remodeling by acting upstream of the ubiquitin-proteasome pathway.Distinguishing between calpain heterodimerization and homodimerization.Effects of concentric and repeated eccentric exercise on muscle damage and calpain-calpastatin gene expression in human skeletal muscle.Possible regulation of the conventional calpain system by skeletal muscle-specific calpain, p94/calpain 3.Structures of human calpain-3 protease core with and without bound inhibitor reveal mechanisms of calpain activation.
P2860
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P2860
Purification of native p94, a muscle-specific calpain, and characterization of its autolysis
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Purification of native p94, a ...... racterization of its autolysis
@en
type
label
Purification of native p94, a ...... racterization of its autolysis
@en
prefLabel
Purification of native p94, a ...... racterization of its autolysis
@en
P2093
P2860
P356
P1433
P1476
Purification of native p94, a ...... racterization of its autolysis
@en
P2093
Kawasaki H
Kolmerer B
Sorimachi H
P2860
P304
P356
10.1042/BJ3350589
P407
P478
335 ( Pt 3)
P577
1998-11-01T00:00:00Z