Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss. - Wikidata - awgldk - TriplyDB

Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss.

Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss.

http://www.wikidata.org/entity/Q42003181

about

Mouse models of intestinal cancer Cyclin D as a therapeutic target in cancer TRIB2 acts downstream of Wnt/TCF in liver cancer cells to regulate YAP and C/EBPα function.Elevated expression of CDK4 in lung cancer.Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles Delta-like 4/Notch signaling promotes Apc Min/+ tumor initiation through angiogenic and non-angiogenic related mechanisms Sensitivity of KRAS-Mutant Colorectal Cancers to Combination Therapy That Cotargets MEK and CDK4/6.Impact of deleterious passenger mutations on cancer progression.APC controls asymmetric Wnt/β-catenin signaling and cardiomyocyte proliferation gradient in the heart Mammalian interphase cdks: dispensable master regulators of the cell cycle.ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation.Activation of tumor cell proliferation by thyroid hormone in a mouse model of follicular thyroid carcinoma.Analysis of inflammatory and lipid metabolic networks across RAW264.7 and thioglycolate-elicited macrophages.Targeting cell cycle and hormone receptor pathways in cancer.Cell cycle proteins as promising targets in cancer therapy MYC-y mice: from tumour initiation to therapeutic targeting of endogenous MYC.Signaling through cyclin D-dependent kinases.Cyclin-dependent kinase inhibitors and the treatment of gastrointestinal cancers.Comparative Analysis of the Effects of Two Probiotic Bacterial Strains on Metabolism and Innate Immunity in the RAW 264.7 Murine Macrophage Cell Line.PD-0332991 induces G1 arrest of colorectal carcinoma cells through inhibition of the cyclin-dependent kinase-6 and retinoblastoma protein axis.Repeated H2 O2 exposure drives cell cycle progression in an in vitro model of ulcerative colitis.Wnt Signaling in Normal and Malignant Stem Cells.APC hypermethylation for early diagnosis of colorectal cancer: a meta-analysis and literature review.NF-κB inducing kinase (NIK) modulates melanoma tumorigenesis by regulating expression of pro-survival factors through the β-catenin pathway.A bioinformatical and functional approach to identify novel strategies for chemoprevention of colorectal cancer.circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family.The establishment of a growth-controllable orthotopic bladder cancer model through the down-regulation of c-myc expression.D-cyclins repress apoptosis in hematopoietic cells by controlling death receptor Fas and its ligand FasL.Influence of miRNA-106b and miRNA-135a on butyrate-regulated expression of p21 and Cyclin D2 in human colon adenoma cells.Targeting Wnt pathway in mantle cell lymphoma-initiating cells.Efficient Wnt mediated intestinal hyperproliferation requires the cyclin D2-CDK4/6 complex.Analysis of apoptosis methods recently used in Cancer Research and Cell Death & Disease publications.Cross-Tissue Identification of Somatic Stem and Progenitor Cells Using a Single-Cell RNA-Sequencing Derived Gene Signature.Usefulness of plasma epigenetic changes of five major genes involved in the pathogenesis of colorectal cancer.Rage signalling promotes intestinal tumourigenesis.Autocrine parathyroid hormone-like hormone promotes intrahepatic cholangiocarcinoma cell proliferation via increased ERK/JNK-ATF2-cyclinD1 signaling.Early diagnostic potential of APC hypermethylation in esophageal cancer.

P2860

Q26785563-19967B61-AAA6-4022-B881-33D13DC1007A Q28242623-21BA7980-8E66-40D7-BEF5-47D21D01C636 Q33557334-8378B607-6D72-4B4B-A1FA-19128BC0DE02 Q34980269-6E86BC02-3E2E-4853-A5C1-BAA1D9B7ABE8 Q35698700-4A02F440-B48C-4070-98A3-6BA8199A4F49 Q36249368-B55522ED-3842-44DB-86CA-4D905DFDCEEA Q36471372-370C77A0-7FBF-431E-8D06-66D14E61B5C7 Q36637272-F4679EA6-B063-4F47-BB13-792CD75B7730 Q36709796-8510BC3B-05EE-4128-8A29-6BE9052FAF45 Q36796448-54497481-BD50-4581-AB28-1D861DA3FF12 Q36949354-E43A5CE6-D6D0-4517-9A38-706C64B9553D Q37058438-C4363BEC-F77F-463C-B6BB-398602159C25 Q37076525-445B680B-E2E8-431F-BC19-D88DB838B216 Q37502364-7E577ED2-BD3C-440A-A4EE-A00FABA8CE0C Q37693690-EF736DAD-47DF-4ED9-B785-CE8587B04945 Q38092448-59B8DC08-D43C-4833-A032-68771A4A4126 Q38104238-548A6CE1-1259-4940-BE3E-3B8898C0EF76 Q38369468-DC18F8BF-AA4D-490E-9805-1E178C42FDC0 Q38781381-05BCB124-74D4-45AA-9FA0-73D7D89CBAB7 Q38932951-27855A9F-5F5F-455B-8042-B5F454AE0581 Q39080578-37304060-3773-49B9-B7AE-5DD4EE791A30 Q39306017-32F203E5-49A4-4200-BC50-8A7A004142C1 Q39313634-7A09D0DB-FBD4-4712-9747-8FA6A158D589 Q39464868-E41B48AE-BF21-4D3F-99A5-C73CD8B1DC3E Q39610270-7B5254A1-CB31-4F29-B261-E642475580AC Q41425937-4C1CB814-8EF2-46DC-8D70-69B46D39071C Q41612126-3E545C02-6911-4DA5-AD4A-B9331336EB3B Q42087817-BAF1E88B-C42E-4FC9-94F0-4BD5DA481896 Q42094255-35680D7C-258F-424D-9785-470B2DDC7385 Q42558443-F4565E81-F57C-42C6-B6AE-7DC6A636B0B2 Q42610836-3C06BBC4-3802-4EBE-A939-96F0E42132A9 Q42632659-8F42E40E-380C-4DDB-BB3A-AA7D751CFCDD Q42778193-D055DE96-3E0A-40E7-BFDE-E1CF9A8C8A60 Q43526081-F59EB0CE-4F39-4A3F-9FF4-8EEB553CB4CB Q43572477-F372C306-A9C8-43CF-8255-041A7326D8DD Q47138859-555A5D5A-4C44-4062-B9C8-0FC214223867 Q49711559-6B7DE414-7711-46BB-9101-80C446D7F592

P2860

Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss.

http://www.wikidata.org/entity/Q42003181

description

2010 nî lūn-bûn

@nan

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

2010年论文

@zh

2010年论文

@zh-cn

name

Cyclin D2-cyclin-dependent kin ...... origenesis following Apc loss.

@en

Cyclin D2-cyclin-dependent kin ...... origenesis following Apc loss.

@nl

type

label

Cyclin D2-cyclin-dependent kin ...... origenesis following Apc loss.

@en

Cyclin D2-cyclin-dependent kin ...... origenesis following Apc loss.

@nl

prefLabel

Cyclin D2-cyclin-dependent kin ...... origenesis following Apc loss.

@en

Cyclin D2-cyclin-dependent kin ...... origenesis following Apc loss.

@nl

P1433

Q42003181-72F33461-98ED-43CD-9D5A-F80F2BFFF87C

P1476

Q42003181-893062EF-1609-4D09-BE8F-76F5A7406668

P2093

Q42003181-151FC76B-6AE9-46C5-A8DB-D90E21B0FADA

Q42003181-2FD52DD5-32DF-462E-A0FA-419BC1953931

Q42003181-3297EF38-3567-4B8A-954E-25223A640FCA

Q42003181-3D94BC75-502B-4EB7-B143-CF8598661043

Q42003181-A0C62CB7-6B25-470E-B3C6-ECCB3C687DDC

Q42003181-C4D9D52C-5496-40D0-B044-EC99CAB3EF46

Q42003181-D3123333-149E-4542-A863-7E877D006063

P2860

Q42003181-06A9E379-12B1-428E-A328-52BF624CD946

Q42003181-2A71E5ED-DABA-411F-B374-348F26ECFCB2

Q42003181-3147654C-B1A8-4084-9D05-3253254290FD

Q42003181-31CA36D9-E57E-4689-B8C1-86D1E77BFE8B

Q42003181-33D04BD5-0567-4E89-B895-F026491BF9B5

Q42003181-3A2AE4BF-BAEE-4289-BD7E-4A02CA79E587

Q42003181-42C86F49-F3CD-44F1-9DC4-ADD16FF2ED58

Q42003181-45622863-2805-4184-8CF0-8CC7394A5F48

Q42003181-601C9BBB-B704-457D-BA98-73AE7068F73A

Q42003181-6146B89F-A9C1-4814-B638-79988CDFEEE9

P304

Q42003181-C9759020-FC35-4D50-9D51-B2292BCA59F8

P31

Q42003181-A7E79CBD-2FC4-4F32-86D7-AC736BB3F80D

P356

Q42003181-5636A32F-BC96-4EAD-892B-C99A62D93849

P407

Q42003181-7F4D6126-66EE-4912-9838-21E3222F65F1

P433

Q42003181-D4982A49-66ED-42CB-96C8-5E347199C50F

P478

Q42003181-7530117B-1C82-4D60-A322-F509D8628CDA

P50

Q42003181-125BD72A-52CE-441A-B86D-821C0233B4DA

Q42003181-14BE9785-A923-425A-B29E-638999442EEA

Q42003181-1554A50C-ADE2-4CFB-9D6E-CD24A6514FCB

Q42003181-7296A5D4-137D-4C9D-B0D1-341B91B85BED

P577

Q42003181-4E06343F-D902-487A-A222-24A0A48AF950

P5875

Q42003181-A3CA01AA-81C8-43FE-8C15-58B214C25F8B

P698

Q42003181-E3B4A279-55C1-4C1D-80E6-B2B93C4C1F24

P932

Q42003181-9904FAB0-6A43-453D-9D02-F839B246D9B9

P356

0008-5472.CAN-10-0315

P1433

Cancer Research

P1476

Cyclin D2-cyclin-dependent kin ...... origenesis following Apc loss.

@en

P2093

Alicia M Cole

http://www.w3.org/2001/XMLSchema#string

Gijs R Van den Brink

http://www.w3.org/2001/XMLSchema#string

Hans Clevers

http://www.w3.org/2001/XMLSchema#string

Kevin Myant

http://www.w3.org/2001/XMLSchema#string

Peter Sicinski

http://www.w3.org/2001/XMLSchema#string

Rachel A Ridgway

http://www.w3.org/2001/XMLSchema#string

Vanesa Muncan

http://www.w3.org/2001/XMLSchema#string

P2860

Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27.

Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

Lessons from hereditary colorectal cancer

Aberrant expression of G1-phase cell cycle regulators in flat and exophytic adenomas of the human colon

Cell cycle kinases as therapeutic targets for cancer

Identification of FAP locus genes from chromosome 5q21

Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice

Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

Myc deletion rescues Apc deficiency in the small intestine

P304

8149-8158

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1158/0008-5472.CAN-10-0315

http://www.w3.org/2001/XMLSchema#string

P407

P433

20

http://www.w3.org/2001/XMLSchema#string

P478

70

http://www.w3.org/2001/XMLSchema#string

P50

Dimitris Athineos

P577

2010-08-24T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

45827721

http://www.w3.org/2001/XMLSchema#string

P698

20736363

http://www.w3.org/2001/XMLSchema#string

P932

2974087

http://www.w3.org/2001/XMLSchema#string