Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase - Wikidata - awgldk - TriplyDB

Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase

Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase

http://www.wikidata.org/entity/Q42033944

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Crystal Structure of the Erythromycin Polyketide Synthase Dehydratase Structural and Biochemical Analyses of Regio- and Stereospecificities Observed in a Type II Polyketide Ketoreductase Structural Studies of an A2-Type Modular Polyketide Synthase Ketoreductase Reveal Features Controlling α-Substituent Stereochemistry Structure and Stereospecificity of the Dehydratase Domain from the Terminal Module of the Rifamycin Polyketide Synthase Structural and functional studies of atrans-acyltransferase polyketide assembly line enzyme that catalyzes stereoselective α- and β-ketoreduction A labile point in mutant amphotericin polyketide synthases Clustering of protein domains for functional and evolutionary studies Elucidation of the cryptic epimerase activity of redox-inactive ketoreductase domains from modular polyketide synthases by tandem equilibrium isotope exchange Insights into radicicol biosynthesis via heterologous synthesis of intermediates and analogs Programming of erythromycin biosynthesis by a modular polyketide synthase Mechanism and stereospecificity of a fully saturating polyketide synthase module: nanchangmycin synthase module 2 and its dehydratase domain.Polyketide intermediate mimics as probes for revealing cryptic stereochemistry of ketoreductase domains.Reprogramming a module of the 6-deoxyerythronolide B synthase for iterative chain elongation.Epimerase and Reductase Activities of Polyketide Synthase Ketoreductase Domains Utilize the Same Conserved Tyrosine and Serine Residues.Stereochemistry of reductions catalyzed by methyl-epimerizing ketoreductase domains of polyketide synthases.Coupled methyl group epimerization and reduction by polyketide synthase ketoreductase domains. Ketoreductase-catalyzed equilibrium isotope exchange.Polyketide stereocontrol: a study in chemical biology.The structures of type I polyketide synthases.Dissecting complex polyketide biosynthesis.Assembly line polyketide synthases: mechanistic insights and unsolved problems.Alkyldihydropyrones, new polyketides synthesized by a type III polyketide synthase from Streptomyces reveromyceticus.Hidden function of catalytic domain in 6-methylsalicylic acid synthase for product release.Total synthesis and study of 6-deoxyerythronolide B by late-stage C-H oxidation.The biochemical basis for stereochemical control in polyketide biosynthesis.A general scheme for synthesis of substrate-based polyketide labels for acyl carrier proteins ClustScan: an integrated program package for the semi-automatic annotation of modular biosynthetic gene clusters and in silico prediction of novel chemical structures.A fungal ketoreductase domain that displays substrate-dependent stereospecificity.Stereospecificity of the dehydratase domain of the erythromycin polyketide synthase.Stereospecificity of ketoreductase domains 1 and 2 of the tylactone modular polyketide synthase.The changing patterns of covalent active site occupancy during catalysis on a modular polyketide synthase multienzyme revealed by ion-trap mass spectrometry.Assembly and absolute configuration of short-lived polyketides from Burkholderia thailandensis.A trans-acting ketoreductase in biosynthesis of a symmetric polyketide dimer SIA7248.Elucidation of the Stereospecificity of C-Methyltransferases from trans-AT Polyketide Synthases.Elucidation of the Cryptic Methyl Group Epimerase Activity of Dehydratase Domains from Modular Polyketide Synthases Using a Tandem Modules Epimerase Assay.Mechanism and Stereochemistry of Polyketide Chain Elongation and Methyl Group Epimerization in Polyether Biosynthesis.Stereospecific Formation of Z-Trisubstituted Double Bonds by the Successive Action of Ketoreductase and Dehydratase Domains from trans-AT Polyketide Synthases.Evaluating Ketoreductase Exchanges as a Means of Rationally Altering Polyketide Stereochemistry.Insights into the stereospecificity of ketoreduction in a modular polyketide synthase.Substrate-dependent stereospecificity of Tyl-KR1: an isolated polyketide synthase ketoreductase domain from Streptomyces fradiae.Substrate-bound structures of a ketoreductase from amphotericin modular polyketide synthase.

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P2860

Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase

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2007 nî lūn-bûn

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Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase

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Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase

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type

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Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase

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Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase

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prefLabel

Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase

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Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase

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Journal of the American Chemical Society

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Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase

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Alice Y Chen

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Chaitan Khosla

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David E Cane

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Roselyne Castonguay

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Weiguo He

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P2860

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Structure of fungal fatty acid synthase and implications for iterative substrate shuttling

Structural basis for substrate delivery by acyl carrier protein in the yeast fatty acid synthase

A tylosin ketoreductase reveals how chirality is determined in polyketides

Structural and Mechanistic Analysis of Protein Interactions in Module 3 of the 6-Deoxyerythronolide B Synthase

Solution structure and proposed domain-domain recognition interface of an acyl carrier protein domain from a modular polyketide synthase

Tolerance and specificity of polyketide synthases

Post-translational modification of polyketide and nonribosomal peptide synthases

Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli.

Polyketide and nonribosomal peptide antibiotics: modularity and versatility.

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