Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase
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Crystal Structure of the Erythromycin Polyketide Synthase DehydrataseStructural and Biochemical Analyses of Regio- and Stereospecificities Observed in a Type II Polyketide KetoreductaseStructural Studies of an A2-Type Modular Polyketide Synthase Ketoreductase Reveal Features Controlling α-Substituent StereochemistryStructure and Stereospecificity of the Dehydratase Domain from the Terminal Module of the Rifamycin Polyketide SynthaseStructural and functional studies of atrans-acyltransferase polyketide assembly line enzyme that catalyzes stereoselective α- and β-ketoreductionA labile point in mutant amphotericin polyketide synthasesClustering of protein domains for functional and evolutionary studiesElucidation of the cryptic epimerase activity of redox-inactive ketoreductase domains from modular polyketide synthases by tandem equilibrium isotope exchangeInsights into radicicol biosynthesis via heterologous synthesis of intermediates and analogsProgramming of erythromycin biosynthesis by a modular polyketide synthaseMechanism and stereospecificity of a fully saturating polyketide synthase module: nanchangmycin synthase module 2 and its dehydratase domain.Polyketide intermediate mimics as probes for revealing cryptic stereochemistry of ketoreductase domains.Reprogramming a module of the 6-deoxyerythronolide B synthase for iterative chain elongation.Epimerase and Reductase Activities of Polyketide Synthase Ketoreductase Domains Utilize the Same Conserved Tyrosine and Serine Residues.Stereochemistry of reductions catalyzed by methyl-epimerizing ketoreductase domains of polyketide synthases.Coupled methyl group epimerization and reduction by polyketide synthase ketoreductase domains. Ketoreductase-catalyzed equilibrium isotope exchange.Polyketide stereocontrol: a study in chemical biology.The structures of type I polyketide synthases.Dissecting complex polyketide biosynthesis.Assembly line polyketide synthases: mechanistic insights and unsolved problems.Alkyldihydropyrones, new polyketides synthesized by a type III polyketide synthase from Streptomyces reveromyceticus.Hidden function of catalytic domain in 6-methylsalicylic acid synthase for product release.Total synthesis and study of 6-deoxyerythronolide B by late-stage C-H oxidation.The biochemical basis for stereochemical control in polyketide biosynthesis.A general scheme for synthesis of substrate-based polyketide labels for acyl carrier proteinsClustScan: an integrated program package for the semi-automatic annotation of modular biosynthetic gene clusters and in silico prediction of novel chemical structures.A fungal ketoreductase domain that displays substrate-dependent stereospecificity.Stereospecificity of the dehydratase domain of the erythromycin polyketide synthase.Stereospecificity of ketoreductase domains 1 and 2 of the tylactone modular polyketide synthase.The changing patterns of covalent active site occupancy during catalysis on a modular polyketide synthase multienzyme revealed by ion-trap mass spectrometry.Assembly and absolute configuration of short-lived polyketides from Burkholderia thailandensis.A trans-acting ketoreductase in biosynthesis of a symmetric polyketide dimer SIA7248.Elucidation of the Stereospecificity of C-Methyltransferases from trans-AT Polyketide Synthases.Elucidation of the Cryptic Methyl Group Epimerase Activity of Dehydratase Domains from Modular Polyketide Synthases Using a Tandem Modules Epimerase Assay.Mechanism and Stereochemistry of Polyketide Chain Elongation and Methyl Group Epimerization in Polyether Biosynthesis.Stereospecific Formation of Z-Trisubstituted Double Bonds by the Successive Action of Ketoreductase and Dehydratase Domains from trans-AT Polyketide Synthases.Evaluating Ketoreductase Exchanges as a Means of Rationally Altering Polyketide Stereochemistry.Insights into the stereospecificity of ketoreduction in a modular polyketide synthase.Substrate-dependent stereospecificity of Tyl-KR1: an isolated polyketide synthase ketoreductase domain from Streptomyces fradiae.Substrate-bound structures of a ketoreductase from amphotericin modular polyketide synthase.
P2860
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P2860
Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase
@en
Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase
@nl
type
label
Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase
@en
Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase
@nl
prefLabel
Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase
@en
Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase
@nl
P2093
P2860
P356
P1476
Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase
@en
P2093
Alice Y Chen
Chaitan Khosla
David E Cane
Roselyne Castonguay
P2860
P304
13758-13769
P356
10.1021/JA0753290
P407
P577
2007-10-06T00:00:00Z