NAADP induces pH changes in the lumen of acidic Ca2+ stores.
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Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADPTPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+Two-pore channels function in calcium regulation in sea star oocytes and embryos.Reconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+Fertilization and nicotinic acid adenine dinucleotide phosphate induce pH changes in acidic Ca(2+) stores in sea urchin eggsTPC: the NAADP discovery channel?Bidirectional Ca²⁺ signaling occurs between the endoplasmic reticulum and acidic organellesThe two-pore channel TPCN2 mediates NAADP-dependent Ca(2+)-release from lysosomal storesTwo-Pore Channels and Parkinson's Disease: Where's the Link?Calcium signaling via two-pore channels: local or global, that is the question.TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADPTwo-pore channels for integrative Ca signaling.The calcium-mobilizing messenger nicotinic acid adenine dinucleotide phosphate participates in sperm activation by mediating the acrosome reactionCalcium- and polyphosphate-containing acidic granules of sea urchin eggs are similar to acidocalcisomes, but are not the targets for NAADPNAADP receptors.Function and dysfunction of two-pore channels.Two-Pore Channels: Lessons from Mutant Mouse ModelsSTIM1 and STIM2 are located in the acidic Ca2+ stores and associates with Orai1 upon depletion of the acidic stores in human plateletsAcidic Ca2+ stores in neurodegeneration.The intracellular Ca²⁺ channels of membrane traffic.Calcium pathway machinery at fertilization in echinodermsThe endoplasmic reticulum, not the pH gradient, drives calcium refilling of lysosomes.The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.Cyclic ADP-Ribose and NAADP in Vascular Regulation and Diseases.The endo-lysosomal system as an NAADP-sensitive acidic Ca(2+) store: role for the two-pore channels.Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease.A link between LRRK2, autophagy and NAADP-mediated endolysosomal calcium signalling.Ca(2+) signals, NAADP and two-pore channels: role in cellular differentiation.A New Perspective of Lysosomal Cation Channel-Dependent Homeostasis in Alzheimer's Disease.Calcium- and polyphosphate-containing acidocalcisomes in chicken egg yolk.A Link between Autophagy and the Pathophysiology of LRRK2 in Parkinson's Disease.Two pore channel 2 (TPC2) inhibits autophagosomal-lysosomal fusion by alkalinizing lysosomal pH.The luminal Ca(2+) chelator, TPEN, inhibits NAADP-induced Ca(2+) release.Aberrant NF-kappaB expression in autism spectrum condition: a mechanism for neuroinflammation.Cytoplasmic nanojunctions between lysosomes and sarcoplasmic reticulum are required for specific calcium signalingTwo-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Signaling in the Heart.mTORC1 controls lysosomal Ca release through the two-pore channel TPC2
P2860
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P2860
NAADP induces pH changes in the lumen of acidic Ca2+ stores.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
NAADP induces pH changes in the lumen of acidic Ca2+ stores.
@en
NAADP induces pH changes in the lumen of acidic Ca2+ stores.
@nl
type
label
NAADP induces pH changes in the lumen of acidic Ca2+ stores.
@en
NAADP induces pH changes in the lumen of acidic Ca2+ stores.
@nl
prefLabel
NAADP induces pH changes in the lumen of acidic Ca2+ stores.
@en
NAADP induces pH changes in the lumen of acidic Ca2+ stores.
@nl
P2860
P356
P1433
P1476
NAADP induces pH changes in the lumen of acidic Ca2+ stores.
@en
P2093
Anthony J Morgan
P2860
P304
P356
10.1042/BJ20060759
P407
P577
2007-03-01T00:00:00Z