Membrane potential-dependent inactivation of voltage-gated ion channels in alpha-cells inhibits glucagon secretion from human islets. - Wikidata - awgldk - TriplyDB

Membrane potential-dependent inactivation of voltage-gated ion channels in alpha-cells inhibits glucagon secretion from human islets.

Membrane potential-dependent inactivation of voltage-gated ion channels in alpha-cells inhibits glucagon secretion from human islets.

http://www.wikidata.org/entity/Q42138516

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Glucagon secretion and signaling in the development of diabetes Paracrine and autocrine interactions in the human islet: more than meets the eye Distinct initial SNARE configurations underlying the diversity of exocytosis Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease Design Principles of Pancreatic Islets: Glucose-Dependent Coordination of Hormone Pulses Roles of Voltage-Gated Tetrodotoxin-Sensitive Sodium Channels NaV1.3 and NaV1.7 in Diabetes and Painful Diabetic Neuropathy CFTR is involved in the regulation of glucagon secretion in human and rodent alpha cells.Zinc in specialized secretory tissues: roles in the pancreas, prostate, and mammary gland.TASK-1 Potassium Channels Limit Pancreatic α-Cell Calcium Influx and Glucagon Secretion.γ-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetes.SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells.A computational systems analysis of factors regulating α cell glucagon secretion.Channeling dysglycemia: ion-channel variations perturbing glucose homeostasis.PYY-Dependent Restoration of Impaired Insulin and Glucagon Secretion in Type 2 Diabetes following Roux-En-Y Gastric Bypass Surgery.Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes.Modeling the pancreatic α-cell: dual mechanisms of glucose suppression of glucagon secretion.Functional identification of islet cell types by electrophysiological fingerprinting.Regulation of glucagon secretion by glucose: paracrine, intrinsic or both?Regulation of glucagon secretion by zinc: lessons from the β cell-specific Znt8 knockout mouse model.Regulation of calcium in pancreatic α- and β-cells in health and disease.Zinc and insulin in pancreatic beta-cells.K(ATP) channels and islet hormone secretion: new insights and controversies.ATP-regulated potassium channels and voltage-gated calcium channels in pancreatic alpha and beta cells: similar functions but reciprocal effects on secretion.Sulfonylureas and their use in clinical practice.Microfluidic perfusion systems for secretion fingerprint analysis of pancreatic islets: applications, challenges and opportunities.Glucose control of glucagon secretion-'There's a brand-new gimmick every year'.Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion.Dapagliflozin stimulates glucagon secretion at high glucose: experiments and mathematical simulations of human A-cells.Per-arnt-sim (PAS) domain kinase (PASK) as a regulator of glucagon secretion.Submembrane ATP and Ca2+ kinetics in α-cells: unexpected signaling for glucagon secretion.LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia In situ electrophysiological examination of pancreatic α cells in the streptozotocin-induced diabetes model, revealing the cellular basis of glucagon hypersecretion.Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression.Sulfonylureas: Scoring beyond START STUDY.Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men.Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion.Matthias Braun, 23 July 1966-16 November 2013.Sitagliptin and Roux-en-Y gastric bypass modulate insulin secretion via regulation of intra-islet PYY.Key Matrix Proteins Within the Pancreatic Islet Basement Membrane Are Differentially Digested During Human Islet Isolation.Consensus Recommendations on Sulfonylurea and Sulfonylurea Combinations in the Management of Type 2 Diabetes Mellitus - International Task Force.

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P2860

Membrane potential-dependent inactivation of voltage-gated ion channels in alpha-cells inhibits glucagon secretion from human islets.

http://www.wikidata.org/entity/Q42138516

description

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Membrane potential-dependent i ...... n secretion from human islets.

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Membrane potential-dependent i ...... n secretion from human islets.

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Membrane potential-dependent i ...... n secretion from human islets.

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Membrane potential-dependent i ...... n secretion from human islets.

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Membrane potential-dependent i ...... n secretion from human islets.

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Membrane potential-dependent i ...... n secretion from human islets.

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Caroline Ward

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Jonathan N Walker

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Makoto Shigeto

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Matthias Braun

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Paul R Johnson

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Quan Zhang

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Reshma Ramracheya

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Stefan Amisten

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P2860

The unique cytoarchitecture of human pancreatic islets has implications for islet cell function

R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion

Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopy.

A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans.

Novel tarantula toxins for subtypes of voltage-dependent potassium channels in the Kv2 and Kv4 subfamilies.

Heteropoda toxin 2 is a gating modifier toxin specific for voltage-gated K+ channels of the Kv4 family.

Hypoglycaemia: the limiting factor in the glycaemic management of Type I and Type II diabetes.

Hypoglycemia in diabetes.

Transient outward potassium current, 'Ito', phenotypes in the mammalian left ventricle: underlying molecular, cellular and biophysical mechanisms.

Zinc and copper: pharmacological probes and endogenous modulators of neuronal excitability.

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