Premature aging in mice activates a systemic metabolic response involving autophagy induction.
about
Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cellsDNA Damage: A Main Determinant of Vascular AgingAutophagy facilitates the development of breast cancer resistance to the anti-HER2 monoclonal antibody trastuzumabAcetylation of yeast AMPK controls intrinsic aging independently of caloric restriction.Rapalogs and mTOR inhibitors as anti-aging therapeuticsXenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil: a new family of gerosuppressant agentsZMPSTE24 defends against influenza and other pathogenic virusesComputer-aided discovery of biological activity spectra for anti-aging and anti-cancer olive oil oleuropeins.The central role of chromatin maintenance in aging.Prelamin A accumulation and stress conditions induce impaired Oct-1 activity and autophagy in prematurely aged human mesenchymal stem cellEarly autophagic response in a novel knock-in model of Huntington diseaseInsulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function.Cellular stress response pathways and ageing: intricate molecular relationshipsCell autonomous and systemic factors in progeria development.Autophagy and ageing: implications for age-related neurodegenerative diseases.The paradox of mitochondrial dysfunction and extended longevity.Promotion of tumor development in prostate cancer by progerinRapamycin treatment of Mandibuloacral dysplasia cells rescues localization of chromatin-associated proteins and cell cycle dynamicsAdiponectin modulates oxidative stress-induced autophagy in cardiomyocytes.Proteasomes, Sir2, and Hxk2 form an interconnected aging network that impinges on the AMPK/Snf1-regulated transcriptional repressor Mig1.Gerosuppressant metformin: less is moreThe functional and pathologic relevance of autophagy proteases.Proteomic profiling of adipose tissue from Zmpste24-/- mice, a model of lipodystrophy and premature aging, reveals major changes in mitochondrial function and vimentin processing.iTRAQ-based analysis of progerin expression reveals mitochondrial dysfunction, reactive oxygen species accumulation and altered proteostasis.Autophagic degradation of farnesylated prelamin A as a therapeutic approach to lamin-linked progeria.Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging.Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.Autophagy drives epidermal deterioration in a Drosophila model of tissue aging.DNA damage accumulation and TRF2 degradation in atypical Werner syndrome fibroblasts with LMNA mutations.Severe growth retardation and early lethality in mice lacking the nuclear localization sequence and C-terminus of PTH-related proteinPrelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion.How to live long and prosper: autophagy, mitochondria, and aging.Autophagy and aging: keeping that old broom working.ZMPSTE24, an integral membrane zinc metalloprotease with a connection to progeroid disorders.Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling.Chaperone-mediated autophagy: selectivity pays off.Quality and quantity control of proteins in senescence.Apoptosis and aging: increased resistance to apoptosis enhances the aging process.SIRT1 and AMPK in regulating mammalian senescence: a critical review and a working model.ZMPSTE24 Is Downstream Effector of Interferon-Induced Transmembrane Antiviral Activity.
P2860
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P2860
Premature aging in mice activates a systemic metabolic response involving autophagy induction.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Premature aging in mice activa ...... involving autophagy induction.
@en
Premature aging in mice activa ...... involving autophagy induction.
@nl
type
label
Premature aging in mice activa ...... involving autophagy induction.
@en
Premature aging in mice activa ...... involving autophagy induction.
@nl
prefLabel
Premature aging in mice activa ...... involving autophagy induction.
@en
Premature aging in mice activa ...... involving autophagy induction.
@nl
P2093
P2860
P50
P921
P356
P1476
Premature aging in mice activa ...... involving autophagy induction
@en
P2093
Alejandro P Ugalde
Guillermo Mariño
Ingrid van der Pluijm
Natalia Salvador-Montoliu
Pedro M Quirós
P2860
P304
P356
10.1093/HMG/DDN120
P577
2008-04-28T00:00:00Z