Regulation of the biosynthesis of insulin-secretory-granule proteins. Co-ordinate translational control is exerted on some, but not all, granule matrix constituents.
about
Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and co-localization with somatostatin in islet delta cellsIdentification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational controlImogen 38: a novel 38-kD islet mitochondrial autoantigen recognized by T cells from a newly diagnosed type 1 diabetic patientPolypyrimidine tract-binding protein promotes insulin secretory granule biogenesisGlucose stimulates the activity of the guanine nucleotide-exchange factor eIF-2B in isolated rat islets of LangerhansMolecular cloning of phogrin, a protein-tyrosine phosphatase homologue localized to insulin secretory granule membranesPrenatal androgen exposure programs metabolic dysfunction in female mice.Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes developmentAn intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic beta cells.Evidence of diminished glucose stimulation and endoplasmic reticulum function in nonoscillatory pancreatic islets.Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure.Real-time detection of single-living pancreatic beta-cell by laser tweezers Raman spectroscopy: high glucose stimulation.New class of cargo protein in Tetrahymena thermophila dense core secretory granulesPolymorphism rs11085226 in the gene encoding polypyrimidine tract-binding protein 1 negatively affects glucose-stimulated insulin secretion.Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus.Distinct glucose-dependent stress responses revealed by translational profiling in pancreatic beta-cells.Plasticity of the beta cell insulin secretory competence: preparing the pancreatic beta cell for the next meal.Islet autoantigens: structure, function, localization, and regulation.Differences in insulin biosynthesis pathway between small and large islets do not correspond to insulin secretionMetabolic control of insulin gene expression and biosynthesis.Rapid changes of mRNA-binding protein levels following glucose and 3-isobutyl-1-methylxanthine stimulation of insulinoma INS-1 cells.Regulation of β-cell function by RNA-binding proteins.Regulation by glucose of the biosynthesis of PC2, PC3 and proinsulin in (ob/ob) mouse islets of Langerhans.The selective recruitment of mRNA to the ER and an increase in initiation are important for glucose-stimulated proinsulin synthesis in pancreatic beta-cells.PERK activation at low glucose concentration is mediated by SERCA pump inhibition and confers preemptive cytoprotection to pancreatic β-cellsProteomics analysis of insulin secretory granules.Glucose-stimulated protein synthesis in pancreatic beta-cells parallels an increase in the availability of the translational ternary complex (eIF2-GTP.Met-tRNAi) and the dephosphorylation of eIF2 alpha.A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moietiesInsulin mediates glucose-stimulated phosphorylation of PHAS-I by pancreatic beta cells. An insulin-receptor mechanism for autoregulation of protein synthesis by translation.Processing and secretion of human carboxypeptidase E by C6 glioma cells.Endoplasmic reticulum Ca2+ is important for the proteolytic processing and intracellular transport of proinsulin in the pancreatic beta-cell.GTP-binding proteins may stimulate insulin biosynthesis in rat pancreatic islets by enhancing the signal-recognition-particle-dependent translocation of the insulin mRNA poly-/mono-some complex to the endoplasmic reticulum.Secretagogue-dependent phosphorylation of phogrin, an insulin granule membrane protein tyrosine phosphatase homologue.mTOR Inhibition: Reduced Insulin Secretion and Sensitivity in a Rat Model of Metabolic Syndrome.Two Dimensional Gel Electrophoresis of Insulin Secretory Granule Proteins from Biosynthetically-Labeled Pancreatic Islets.Co-secretion of carboxypeptidase H and insulin from isolated rat islets of Langerhans.The post-translational processing of chromogranin A in the pancreatic islet: involvement of the eukaryote subtilisin PC2.Insulin secretory granule biogenesis. Co-ordinate regulation of the biosynthesis of the majority of constituent proteins.Cooperativity between the preproinsulin mRNA untranslated regions is necessary for glucose-stimulated translation.Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin.
P2860
Q22008790-634FBB1A-C69F-499F-AFCA-FE52454BB69EQ24522941-64E781C6-3522-44BF-AE24-4B4B33172AC2Q28118623-26C5E1E7-0F43-4963-AFAD-9D81DAEDF521Q28567445-9004D18D-0AAB-45F1-AB81-7C7438497C25Q28574256-F3FB6D95-E560-4B4B-9D55-C46B8D738531Q28583729-C29AA146-A87E-4E6B-BBE1-95FD4B22AFE1Q30421731-CFE55565-BD05-47CD-AF0E-4A3B2C690579Q30422344-3DA0443F-5664-40E5-95A9-5925C1582924Q30435561-06F4A1D1-9942-4496-827A-F35AB691FCDBQ30437173-BEB61636-6F81-49B6-A6F0-B059DF3947D0Q30438373-B8AB34A9-F41C-4AEE-94C9-0C342F038BB4Q33525636-7E45CB4F-10D6-4AD7-B324-40E141CE3866Q33903802-67CD2EDE-29D8-48F2-8296-73A70954733BQ34450307-3BE7B2D6-7AEF-43C6-8E34-B2F3572597B3Q35552583-BE84F4BC-15B7-4834-8DA4-4C263307C526Q35695491-62067C6A-FCB5-4F0B-B236-2DA86C1AFAD3Q35794504-A008504E-A053-4069-B805-9907ACC7FC85Q36119378-B9A4A0C1-8285-4C9A-A155-0A673095C95AQ36930367-7FEED857-CB9D-4FCC-95D4-C01E3100DB3BQ37039928-BC49E67C-8BDA-4550-8E3B-1AD6DF31F557Q37113844-317EF5B3-E511-4132-827B-FCDE0C24D5ACQ38170369-177DC4B6-B3C2-4E89-8A12-6D01E388A206Q38301139-7ED3CBE9-7F32-4346-B9C1-D211BFF58BF8Q39498096-C3212147-09CF-4DD9-9681-FD21E1E42D63Q39613819-0D685BB8-9095-45EB-A543-78A021ECE2B2Q40167745-7EAFAAB3-AEA0-45D0-A96C-822CFED0C229Q40505852-698C6390-A908-4676-8819-5D746C2BE7DAQ41035647-7AA76A90-F29A-46AD-9C01-7805B366CED7Q41057722-48F7248F-255B-455A-9637-86C6954809A5Q41652608-091E239A-2032-4B4B-8964-D6495BF7E3DAQ41849212-53BAFA26-A628-40F4-AD64-579E761CBE33Q41935147-BB7DB122-3636-46BD-812C-823357F38742Q42009948-E8F7CD75-DDFE-4F90-BFCF-ECC091BD6925Q42418240-22B2DA76-3C28-41D1-AE5C-107EE59CF9B0Q42502369-EB28253A-B3A7-41FD-A8AF-DA5270164932Q42804937-1E7E65EC-F891-4062-A6C0-FA6E59866499Q42832903-BD44AE7F-7476-44E1-85A4-5BA9DBA54E2AQ42859781-A82D86FA-A48A-424B-A486-C3D985510F81Q43571532-BF36B662-CCD0-451D-8FB3-37F5CC7F1395Q44556045-066A130D-1272-4728-B89C-55D7345D0261
P2860
Regulation of the biosynthesis of insulin-secretory-granule proteins. Co-ordinate translational control is exerted on some, but not all, granule matrix constituents.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年学术文章
@wuu
1989年学术文章
@zh-cn
1989年学术文章
@zh-hans
1989年学术文章
@zh-my
1989年学术文章
@zh-sg
1989年學術文章
@yue
1989年學術文章
@zh
1989年學術文章
@zh-hant
name
Regulation of the biosynthesis ...... , granule matrix constituents.
@en
Regulation of the biosynthesis ...... , granule matrix constituents.
@nl
type
label
Regulation of the biosynthesis ...... , granule matrix constituents.
@en
Regulation of the biosynthesis ...... , granule matrix constituents.
@nl
prefLabel
Regulation of the biosynthesis ...... , granule matrix constituents.
@en
Regulation of the biosynthesis ...... , granule matrix constituents.
@nl
P2093
P2860
P356
P1433
P1476
Regulation of the biosynthesis ...... , granule matrix constituents.
@en
P2093
P2860
P304
P356
10.1042/BJ2570431
P407
P577
1989-01-01T00:00:00Z