The adenovirus type 5 E1B-55K oncoprotein is a highly active shuttle protein and shuttling is independent of E4orf6, p53 and Mdm2.
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SUMO modification of E1B-55K oncoprotein regulates isoform-specific binding to the tumour suppressor protein PMLSox10 is an active nucleocytoplasmic shuttle protein, and shuttling is crucial for Sox10-mediated transactivationThe NS2 proteins of parvovirus minute virus of mice are required for efficient nuclear egress of progeny virions in mouse cells.Adenovirus Early Proteins and Host SumoylationNuclear export is evolutionarily conserved in CVC paired-like homeobox proteins and influences protein stability, transcriptional activation, and extracellular secretion.Adenovirus type 5 early region 1B 55-kDa oncoprotein can promote cell transformation by a mechanism independent from blocking p53-activated transcriptionAdenovirus type 5 early region 1B 55K oncoprotein-dependent degradation of cellular factor Daxx is required for efficient transformation of primary rodent cellsDegradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complexSPOC1-mediated antiviral host cell response is antagonized early in human adenovirus type 5 infectionThe adenovirus-2 E1B-55K protein interacts with a mSin3A/histone deacetylase 1 complex.Investigation of nucleo-cytoplasmic transport using UV-guided microinjection.Identification of three functions of the adenovirus e4orf6 protein that mediate p53 degradation by the E4orf6-E1B55K complexSUMO-1 modification required for transformation by adenovirus type 5 early region 1B 55-kDa oncoproteinSequestration of p53 in the cytoplasm by adenovirus type 12 E1B 55-kilodalton oncoprotein is required for inhibition of p53-mediated apoptosis.Adenovirus E1B 55-kilodalton protein is a p53-SUMO1 E3 ligase that represses p53 and stimulates its nuclear export through interactions with promyelocytic leukemia nuclear bodies.Adenovirus E1B 55-kilodalton protein is required for both regulation of mRNA export and efficient entry into the late phase of infection in normal human fibroblastsE4orf6 variants with separate abilities to augment adenovirus replication and direct nuclear localization of the E1B 55-kilodalton protein.Export of adenoviral late mRNA from the nucleus requires the Nxf1/Tap export receptor.Effects of mutations in the adenoviral E1B 55-kilodalton protein coding sequence on viral late mRNA metabolism.An activity associated with human chromosome 21 permits nuclear colocalization of the adenovirus E1B-55K and E4orf6 proteins and promotes viral late gene expression.Adenovirus ubiquitin-protein ligase stimulates viral late mRNA nuclear export.Intranuclear targeting and nuclear export of the adenovirus E1B-55K protein are regulated by SUMO1 conjugation.Timely synthesis of the adenovirus type 5 E1B 55-kilodalton protein is required for efficient genome replication in normal human cells.Oncolytic viral therapies.Role of the RNA recognition motif of the E1B 55 kDa protein in the adenovirus type 5 infectious cycle.RUNX1 permits E4orf6-directed nuclear localization of the adenovirus E1B-55K protein and associates with centers of viral DNA and RNA synthesisAggresome formation by the adenoviral protein E1B55K is not conserved among adenovirus species and is not required for efficient degradation of nuclear substratesRegulation of the nucleocytoplasmic trafficking of viral and cellular proteins by ubiquitin and small ubiquitin-related modifiers.Long story short: p53 mediates innate immunity.Adenovirus E1B 55-kilodalton protein: multiple roles in viral infection and cell transformation.An oncolytic adenovirus that expresses the HAb18 and interleukin 24 genes exhibits enhanced antitumor activity in hepatocellular carcinoma cells.Tinkering with translation: protein synthesis in virus-infected cells.Analysis of the Cullin binding sites of the E4orf6 proteins of human adenovirus E3 ubiquitin ligases.Diverse mechanisms evolved by DNA viruses to inhibit early host defenses.CRM1-dependent transport supports cytoplasmic accumulation of adenoviral early transcripts.Two distinct activities contribute to the oncogenic potential of the adenovirus type 5 E4orf6 protein.Analyses of single-amino-acid substitution mutants of adenovirus type 5 E1B-55K proteinThe adenovirus type 5 E1B-55K oncoprotein actively shuttles in virus-infected cells, whereas transport of E4orf6 is mediated by a CRM1-independent mechanism.Arginine methylation of human adenovirus type 5 L4 100-kilodalton protein is required for efficient virus production.Distinct requirements of adenovirus E1b55K protein for degradation of cellular substrates.
P2860
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P2860
The adenovirus type 5 E1B-55K oncoprotein is a highly active shuttle protein and shuttling is independent of E4orf6, p53 and Mdm2.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
The adenovirus type 5 E1B-55K ...... ndent of E4orf6, p53 and Mdm2.
@en
The adenovirus type 5 E1B-55K ...... ndent of E4orf6, p53 and Mdm2.
@nl
type
label
The adenovirus type 5 E1B-55K ...... ndent of E4orf6, p53 and Mdm2.
@en
The adenovirus type 5 E1B-55K ...... ndent of E4orf6, p53 and Mdm2.
@nl
prefLabel
The adenovirus type 5 E1B-55K ...... ndent of E4orf6, p53 and Mdm2.
@en
The adenovirus type 5 E1B-55K ...... ndent of E4orf6, p53 and Mdm2.
@nl
P2093
P356
P1433
P1476
The adenovirus type 5 E1B-55K ...... endent of E4orf6, p53 and Mdm2
@en
P2093
P2888
P304
P356
10.1038/SJ.ONC.1203395
P407
P50
P577
2000-02-01T00:00:00Z
P5875
P6179
1000002825