Quantitative lid dynamics of MDM2 reveals differential ligand binding modes of the p53-binding cleft.
about
MDM4 binds ligands via a mechanism in which disordered regions become structuredEfficient Atomistic Simulation of Pathways and Calculation of Rate Constants for a Protein-Peptide Binding Process: Application to the MDM2 Protein and an Intrinsically Disordered p53 Peptide.Elucidation of Ligand-Dependent Modulation of Disorder-Order Transitions in the Oncoprotein MDM2In vitro selection of mutant HDM2 resistant to Nutlin inhibitionTransient Protein States in Designing Inhibitors of the MDM2-p53 InteractionAn Ultrahigh Affinity d -Peptide Antagonist Of MDM2The structure of an MDM2-Nutlin-3a complex solved by the use of a validated MDM2 surface-entropy reduction mutantStructural basis of how stress-induced MDMX phosphorylation activates p53Simulating molecular mechanisms of the MDM2-mediated regulatory interactions: a conformational selection model of the MDM2 lid dynamicsReliable resonance assignments of selected residues of proteins with known structure based on empirical NMR chemical shift predictionModulation of p53 binding to MDM2: computational studies reveal important roles of Tyr100Protein side-chain dynamics and residual conformational entropyTrapping moving targets with small molecules.Discovery of Novel Isatin-Based p53 InducersInterrogation of MDM2 phosphorylation in p53 activation using native chemical ligation: the functional role of Ser17 phosphorylation in MDM2 reexamined.Structural convergence of unstructured p53 family transactivation domains in MDM2 recognition.Competitive binding between dynamic p53 transactivation subdomains to human MDM2 protein: implications for regulating the p53·MDM2/MDMX interaction.On the interaction mechanisms of a p53 peptide and nutlin with the MDM2 and MDMX proteins: a Brownian dynamics study.Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry?Markov models of the apo-MDM2 lid region reveal diffuse yet two-state binding dynamics and receptor poses for computational docking.In Silico Improvement of beta3-peptide inhibitors of p53 x hDM2 and p53 x hDMXGeneralized indirect covariance NMR formalism for establishment of multidimensional spin correlationsProtein-peptide molecular docking with large-scale conformational changes: the p53-MDM2 interaction.Heterogeneous Hydration of p53/MDM2 Complex.Using NMR to study fast dynamics in proteins: methods and applications.Microsecond simulations of mdm2 and its complex with p53 yield insight into force field accuracy and conformational dynamics.Understanding small-molecule binding to MDM2: insights into structural effects of isoindolinone inhibitors from NMR spectroscopy.Accurate sampling of high-frequency motions in proteins by steady-state (15)N-{(1)H} nuclear Overhauser effect measurements in the presence of cross-correlated relaxation.Regulation of the E3 ubiquitin ligase activity of MDM2 by an N-terminal pseudo-substrate motif.The C terminus of p53 binds the N-terminal domain of MDM2.Current and emerging opportunities for molecular simulations in structure-based drug design.Characterizing the conformational landscape of MDM2-binding p53 peptides using Molecular Dynamics simulations.Effect of a Paramagnetic Spin Label on the Intrinsically Disordered Peptide Ensemble of Amyloid-β.Role of the N-terminal lid in regulating the interaction of phosphorylated MDMX with p53.Regulation of apoptosis by an intrinsically disordered region of Bcl-xL.
P2860
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P2860
Quantitative lid dynamics of MDM2 reveals differential ligand binding modes of the p53-binding cleft.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Quantitative lid dynamics of M ...... odes of the p53-binding cleft.
@en
Quantitative lid dynamics of M ...... odes of the p53-binding cleft.
@nl
type
label
Quantitative lid dynamics of M ...... odes of the p53-binding cleft.
@en
Quantitative lid dynamics of M ...... odes of the p53-binding cleft.
@nl
prefLabel
Quantitative lid dynamics of M ...... odes of the p53-binding cleft.
@en
Quantitative lid dynamics of M ...... odes of the p53-binding cleft.
@nl
P2093
P356
P1476
Quantitative lid dynamics of M ...... modes of the p53-binding cleft
@en
P2093
Eric Johnson
Fengli Zhang
Lei Bruschweiler-Li
Rafael Brüschweiler
P304
P356
10.1021/JA800201J
P407
P577
2008-04-25T00:00:00Z