Restricted Ig variable region gene expression among Ly-1+ B cell lymphomas.
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Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemiaMost peripheral B cells in mice are ligand selected.Molecular cloning of the primary IgH repertoire: a quantitative analysis of VH gene usage in adult miceSequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generationHuman chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expressionDevelopmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia.The PGE2/IL-10 Axis Determines Susceptibility of B-1 Cell-Derived Phagocytes (B-1CDP) to Leishmania major Infection.Autoreactive B-1 B cells: constraints on natural autoantibody B cell antigen receptorsExtensive and selective mutation of a rearranged VH5 gene in human B cell chronic lymphocytic leukemia.Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation.Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice.Natural autoantibodies to thymocytes: origin, VH genes, fine specificities, and the role of Thy-1 glycoprotein.The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary responseRestricted immunoglobulin variable region gene usage by normal Ly-1 (CD5+) B cells that recognize phosphatidyl choline.Lack of extensive mutations in the VH5 genes used in common B cell chronic lymphocytic leukemia.Restricted kappa chain expression in early ontogeny: biased utilization of V kappa exons and preferential V kappa-J kappa recombinationsDevelopment of B-1 cells: segregation of phosphatidyl choline-specific B cells to the B-1 population occurs after immunoglobulin gene expression.Facultative role of germinal centers and T cells in the somatic diversification of IgVH genesB cell antigen receptor specificity and surface density together determine B-1 versus B-2 cell development.Pathogenic profiles and molecular signatures of antinuclear autoantibodies rescued from NZM2410 lupus miceB-1 cell development: evidence for an uncommitted immunoglobulin (Ig)M+ B cell precursor in B-1 cell differentiation.Expansion of B-1a Cells with Germline Heavy Chain Sequence in Lupus Mice.Multispecificity of immunoglobulin M antibodies raised against advanced glycation end products: involvement of electronegative potential of antigensClonal evolution of a follicular lymphoma: evidence for antigen selection.Predominant VH genes expressed in innate antibodies are associated with distinctive antigen-binding sitesTumorigenesis mediated by an antigen receptor.Adult BM generates CD5+ B1 cells containing abundant N-region additions.Early generated B1 B cells with restricted BCRs become chronic lymphocytic leukemia with continued c-Myc and low Bmf expression.B-1a cell diversity: nontemplated addition in B-1a cell Ig is determined by progenitor population and developmental location.Atypical Response of B-1 Cells to BCR Ligation: A Speculative Model.B-1a, B-1b and B-2 B cells display unique VHDJH repertoires formed at different stages of ontogeny and under different selection pressures.VHDJH gene sequences and antigen reactivity of monoclonal antibodies produced by human B-1 cells: evidence for somatic selection.The peritoneal cavity B-2 antibody repertoire appears to reflect many of the same selective pressures that shape the B-1a and B-1b repertoires.Massively Parallel Sequencing of Peritoneal and Splenic B Cell Repertoires Highlights Unique Properties of B-1 Cell Antibodies.
P2860
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P2860
Restricted Ig variable region gene expression among Ly-1+ B cell lymphomas.
description
1988 nî lūn-bûn
@nan
1988年の論文
@ja
1988年学术文章
@wuu
1988年学术文章
@zh-cn
1988年学术文章
@zh-hans
1988年学术文章
@zh-my
1988年学术文章
@zh-sg
1988年學術文章
@yue
1988年學術文章
@zh
1988年學術文章
@zh-hant
name
Restricted Ig variable region gene expression among Ly-1+ B cell lymphomas.
@en
Restricted Ig variable region gene expression among Ly-1+ B cell lymphomas.
@nl
type
label
Restricted Ig variable region gene expression among Ly-1+ B cell lymphomas.
@en
Restricted Ig variable region gene expression among Ly-1+ B cell lymphomas.
@nl
prefLabel
Restricted Ig variable region gene expression among Ly-1+ B cell lymphomas.
@en
Restricted Ig variable region gene expression among Ly-1+ B cell lymphomas.
@nl
P2093
P1476
Restricted Ig variable region gene expression among Ly-1+ B cell lymphomas
@en
P2093
P304
P407
P577
1988-10-01T00:00:00Z