The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response
about
A surrogate-based approach for post-genomic partner identificationRegulation of germinal center B-cell differentiationMSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sitesDisruption of the Bcl6 gene results in an impaired germinal center formationSomatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution patternNormal induction but attenuated progression of germinal center responses in BAFF and BAFF-R signaling-deficient miceM17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in miceMice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normallyThe lupus-prone NZM2410/NZW strain-derived Sle1b sublocus alters the germinal center checkpoint in female mice in a B cell-intrinsic manner.Immunoglobulin heavy chain gene expression in peripheral blood B lymphocytes.Most peripheral B cells in mice are ligand selected.The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response.Analysis of somatic mutation in five B cell subsets of human tonsil.Absence of N addition facilitates B cell development, but impairs immune responses.Molecular approaches to the study of human B-cell and (auto)antibody repertoire generation and selection.The dynamics of T cell-dependent B cell responses in vivo.Autoreactivity in human IgG+ memory B cells.Chronic spinal cord injury impairs primary antibody responses but spares existing humoral immunity in miceA Public Database of Memory and Naive B-Cell Receptor SequencesMaturation and dispersal of B-cell clones during T cell-dependent antibody responses.The development of B cells and the B-cell repertoire in the microenvironment of the germinal center.Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation.Natural occurrence and origin of somatically mutated memory B cells in miceIn situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers.Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory.Clonal analysis of a human antibody response. II. Sequences of the VH genes of human IgM, IgG, and IgA to rabies virus reveal preferential utilization of VHIII segments and somatic hypermutationHypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: implications for the location of cis-acting elements required for somatic mutationAntigen-driven B cell differentiation in vivoIn situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cellsAltering the antibody repertoire via transgene homologous recombination: evidence for global and clone-autonomous regulation of antigen-driven B cell differentiation.Facultative role of germinal centers and T cells in the somatic diversification of IgVH genesTracing the development of single memory-lineage B cells in a highly defined immune response.Isotype-specific selection of high affinity memory B cells in nasal-associated lymphoid tissueVery low affinity B cells form germinal centers, become memory B cells, and participate in secondary immune responses when higher affinity competition is reducedThe transcriptional promoter regulates hypermutation of the antibody heavy chain locus.Autoimmunity in coxsackievirus B3 induced myocarditis.Early appearance of germinal center-derived memory B cells and plasma cells in blood after primary immunization.Intrinsic properties of human and murine memory B cells.Defect in IgV gene somatic hypermutation in common variable immuno-deficiency syndromeComplex Antigens Drive Permissive Clonal Selection in Germinal Centers.
P2860
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P2860
The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年学术文章
@wuu
1990年学术文章
@zh-cn
1990年学术文章
@zh-hans
1990年学术文章
@zh-my
1990年学术文章
@zh-sg
1990年學術文章
@yue
1990年學術文章
@zh
1990年學術文章
@zh-hant
name
The repertoire of somatic anti ...... ssed in the secondary response
@ast
The repertoire of somatic anti ...... ssed in the secondary response
@en
type
label
The repertoire of somatic anti ...... ssed in the secondary response
@ast
The repertoire of somatic anti ...... ssed in the secondary response
@en
prefLabel
The repertoire of somatic anti ...... ssed in the secondary response
@ast
The repertoire of somatic anti ...... ssed in the secondary response
@en
P2860
P356
P1476
The repertoire of somatic anti ...... ssed in the secondary response
@en
P2093
P2860
P304
P356
10.1084/JEM.172.6.1681
P407
P577
1990-12-01T00:00:00Z