Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.
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Sustained Isoprostane E2 Elevation, Inflammation and Fibrosis after Acute Ischaemia-Reperfusion Injury Are Reduced by Pregnane X Receptor ActivationPhenobarbital mediates an epigenetic switch at the constitutive androstane receptor (CAR) target gene Cyp2b10 in the liver of B6C3F1 miceStructural and functional similarity of amphibian constitutive androstane receptor with mammalian pregnane X receptorNon-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylomeScientific and Regulatory Policy Committee (SRPC) Review: Interpretation and Use of Cell Proliferation Data in Cancer Risk Assessment.Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activatorXenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicitiesP2Y2 purinergic receptor activation is essential for efficient hepatocyte proliferation in response to partial hepatectomy.Selective phthalate activation of naturally occurring human constitutive androstane receptor splice variants and the pregnane X receptorOrtho-aminoazotoluene activates mouse constitutive androstane receptor (mCAR) and increases expression of mCAR target genes.Multi-species analyses of direct activators of the constitutive androstane receptor.Transcriptional Regulation of CYP3A4/2B6/2C9 Mediated via Nuclear Receptor PXR by Helicid and Its MetabolitesSmall-molecule modulators of the constitutive androstane receptor.Small-molecule modulators of PXR and CAR.Bioinformatic analysis of microRNA networks following the activation of the constitutive androstane receptor (CAR) in mouse liverRNA-Seq reveals common and unique PXR- and CAR-target gene signatures in the mouse liver transcriptome.Genome-wide analysis of human constitutive androstane receptor (CAR) transcriptome in wild-type and CAR-knockout HepaRG cellsDifferential effects of clinically used derivatives and metabolites of artemisinin in the activation of constitutive androstane receptor isoformsExposure to PFOA and PFOS and fetal growth: a critical merging of toxicological and epidemiological data.Expression of human CAR splicing variants in BAC-transgenic miceNonsterol Isoprenoids Activate Human Constitutive Androstane Receptor in an Isoform-Selective Manner in Primary Cultured Mouse Hepatocytes.Evidence that the capacity of nongenotoxic carcinogens to induce oxidative stress is subject to marked variability.Pregnane X Receptor and Cancer: Context-Specificity is Key.Characterizing drug-metabolizing enzymes and transporters that are bona fide CAR-target genes in mouse intestineIndirect activation of the SV23 and SV24 splice variants of human constitutive androstane receptor: analysis with 3-hydroxyflavone and its analoguesSignaling control of the constitutive androstane receptor (CAR)Computational modeling identifies key gene regulatory interactions underlying phenobarbital-mediated tumor promotion.Using mode of action information to improve regulatory decision-making: an ECETOC/ILSI RF/HESI workshop overview.Knockout and transgenic mice in glutathione transferase research.Liver hypertrophy: a review of adaptive (adverse and non-adverse) changes--conclusions from the 3rd International ESTP Expert Workshop.Xenobiotic receptor humanized mice and their utility.Role of the constitutive androstane receptor in obesity and type 2 diabetes: a case study of the endobiotic function of a xenobiotic receptor.Minireview: endoplasmic reticulum stress: control in protein, lipid, and signal homeostasis.Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications.Mode of action analysis for pesticide-induced rodent liver tumours involving activation of the constitutive androstane receptor: relevance to human cancer risk.Risk assessments for chronic exposure of children and prospective parents to ethylbenzene (CAS No. 100-41-4).The regulation of human hepatic drug transporter expression by activation of xenobiotic-sensing nuclear receptors.Xenobiotic CAR activators induce Dlk1-Dio3 locus non-coding RNA expression in mouse liver.Hepatotoxic effects of cyproconazole and prochloraz in wild-type and hCAR/hPXR mice.Constitutive androstane receptor regulates the intestinal mucosal response to injury.
P2860
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P2860
Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
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2010年學術文章
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2010年學術文章
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name
Human constitutive androstane ...... arbital and chlordane in vivo.
@en
Human constitutive androstane receptor
@nl
type
label
Human constitutive androstane ...... arbital and chlordane in vivo.
@en
Human constitutive androstane receptor
@nl
prefLabel
Human constitutive androstane ...... arbital and chlordane in vivo.
@en
Human constitutive androstane receptor
@nl
P2093
P2860
P50
P356
P1476
Human constitutive androstane ...... barbital and chlordane in vivo
@en
P2093
Clifford R Elcombe
Conrad C Bower
Jillian Ross
Ortwin Vogel
Simon M Plummer
P2860
P304
P356
10.1093/TOXSCI/KFQ118
P577
2010-04-19T00:00:00Z