A lithium-induced conformational change in serotonin transporter alters cocaine binding, ion conductance, and reactivity of Cys-109.
about
Conformational flexibility of transmembrane helix VII of the human serotonin transporter impacts ion dependence and transport.The second sodium site in the dopamine transporter controls cation permeation and is regulated by chloride.Early fluorescence signals detect transitions at mammalian serotonin transporters.Ionic currents in the human serotonin transporter reveal inconsistencies in the alternating access hypothesisCytoplasmic permeation pathway of neurotransmitter transporters.Characterization of a functional bacterial homologue of sodium-dependent neurotransmitter transporters.The significance of molecular slips in transport systems.Unifying concept of serotonin transporter-associated currentsInvolvement of serotonin transporter extracellular loop 1 in serotonin binding and transport.Functional consequences of sulfhydryl modification of the γ-aminobutyric acid transporter 1 at a single solvent-exposed cysteine residue.Helix XI contributes to the entrance of the serotonin transporter permeation pathway.The two Na+ sites in the human serotonin transporter play distinct roles in the ion coupling and electrogenicity of transportUnderstanding the molecular pharmacology of the serotonergic system: using fluoxetine as a model.Cationic interactions at the human dopamine transporter reveal binding conformations for dopamine distinguishable from those for the cocaine analog 2 alpha-carbomethoxy-3 alpha-(4-fluorophenyl)tropane.Elucidating conformational changes in the gamma-aminobutyric acid transporter-1.Conformational basis for the Li(+)-induced leak current in the rat gamma-aminobutyric acid (GABA) transporter-1.A dualistic conformational response to substrate binding in the human serotonin transporter reveals a high affinity state for serotonin.Substrate-induced conformational changes of extracellular loop 1 in the glycine transporter GLYT2.Serotonin transporter function and pharmacology are sensitive to expression level: evidence for an endogenous regulatory factor.Analysis of transmembrane domain 2 of rat serotonin transporter by cysteine scanning mutagenesis.The cytoplasmic substrate permeation pathway of serotonin transporter.An aspartate residue in the external vestibule of GLYT2 (glycine transporter 2) controls cation access and transport coupling.
P2860
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P2860
A lithium-induced conformational change in serotonin transporter alters cocaine binding, ion conductance, and reactivity of Cys-109.
description
2001 nî lūn-bûn
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2001年の論文
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2001年学术文章
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2001年学术文章
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@zh-hans
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name
A lithium-induced conformation ...... ce, and reactivity of Cys-109.
@en
A lithium-induced conformation ...... ce, and reactivity of Cys-109.
@nl
type
label
A lithium-induced conformation ...... ce, and reactivity of Cys-109.
@en
A lithium-induced conformation ...... ce, and reactivity of Cys-109.
@nl
prefLabel
A lithium-induced conformation ...... ce, and reactivity of Cys-109.
@en
A lithium-induced conformation ...... ce, and reactivity of Cys-109.
@nl
P2093
P2860
P356
P1476
A lithium-induced conformation ...... ce, and reactivity of Cys-109.
@en
P2093
Androutsellis-Theotokis A
Moczydlowski E
P2860
P304
30942-30947
P356
10.1074/JBC.M104653200
P407
P577
2001-06-14T00:00:00Z