beta-Cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats.
about
Endoplasmic reticulum stress and type 2 diabetesEndoplasmic reticulum stress in the β-cell pathogenesis of type 2 diabetesTransamination is required for {alpha}-ketoisocaproate but not leucine to stimulate insulin secretionPPARdelta is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunctionEnhanced rat beta-cell proliferation in 60% pancreatectomized islets by increased glucose metabolic flux through pyruvate carboxylase pathwayTranscriptional regulation of the distal promoter of the rat pyruvate carboxylase gene by hepatocyte nuclear factor 3beta/Foxa2 and upstream stimulatory factors in insulinoma cellsMalic enzyme is present in mouse islets and modulates insulin secretionResveratrol regulates pathologic angiogenesis by a eukaryotic elongation factor-2 kinase-regulated pathway.Reduction of islet pyruvate carboxylase activity might be related to the development of type 2 diabetes mellitus in Agouti-K miceSweet taste receptors regulate basal insulin secretion and contribute to compensatory insulin hypersecretion during the development of diabetes in male mice.Regulation of pyruvate metabolism and human diseaseRegulation of insulin secretion: role of mitochondrial signalling.Pyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal beta-cells.Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue.Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion.Cytosolic and mitochondrial malic enzyme isoforms differentially control insulin secretion.Islet beta cell failure in type 2 diabetesInvestigating the roles of mitochondrial and cytosolic malic enzyme in insulin secretion.Acetyl-CoA carboxylases 1 and 2 show distinct expression patterns in rats and humans and alterations in obesity and diabetes.A role for cytosolic isocitrate dehydrogenase as a negative regulator of glucose signaling for insulin secretion in pancreatic ß-cells.Geniposide regulates glucose-stimulated insulin secretion possibly through controlling glucose metabolism in INS-1 cells.Mechanistic insights into pancreatic beta-cell mass regulation by glucose and free fatty acids.Inhibitors of Pyruvate CarboxylaseFree fatty acids block glucose-induced β-cell proliferation in mice by inducing cell cycle inhibitors p16 and p18Compensatory Islet Response to Insulin Resistance Revealed by Quantitative Proteomics.Sunflower Oil but Not Fish Oil Resembles Positive Effects of Virgin Olive Oil on Aged Pancreas after Life-Long Coenzyme Q Addition.Nr2e1 Deficiency Augments Palmitate-Induced Oxidative Stress in Beta Cells.Pancreatic beta cell mass PET imaging and quantification with [11C]DTBZ and [18F]FP-(+)-DTBZ in rodent models of diabetes.Metabolic cycling in control of glucose-stimulated insulin secretionPeroxisome proliferator-activated receptor γ (PPARγ) and its target genes are downstream effectors of FoxO1 protein in islet β-cells: mechanism of β-cell compensation and failure.Protein malnutrition potentiates the amplifying pathway of insulin secretion in adult obese mice.ER stress in rodent islets of Langerhans is concomitant with obesity and β-cell compensation but not with β-cell dysfunction and diabetes.Loss of coupling between calcium influx, energy consumption and insulin secretion associated with development of hyperglycaemia in the UCD-T2DM rat model of type 2 diabetes.Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndromeThe role of pyruvate carboxylase in insulin secretion and proliferation in rat pancreatic beta cells.Chronic reduction of the cytosolic or mitochondrial NAD(P)-malic enzyme does not affect insulin secretion in a rat insulinoma cell line.Longer-Term Physiological and Metabolic Effects of Gastric Bypass SurgeryThe pyruvate carboxylase-pyruvate dehydrogenase axis in islet pyruvate metabolism: Going round in circles?Retinoic acid receptor β2 agonists restore glycaemic control in diabetes and reduce steatosis.SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice.
P2860
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P2860
beta-Cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
beta-Cell adaptation to insuli ...... nondiabetic Zucker fatty rats.
@en
beta-Cell adaptation to insuli ...... nondiabetic Zucker fatty rats.
@nl
type
label
beta-Cell adaptation to insuli ...... nondiabetic Zucker fatty rats.
@en
beta-Cell adaptation to insuli ...... nondiabetic Zucker fatty rats.
@nl
prefLabel
beta-Cell adaptation to insuli ...... nondiabetic Zucker fatty rats.
@en
beta-Cell adaptation to insuli ...... nondiabetic Zucker fatty rats.
@nl
P2093
P2860
P356
P1476
beta-Cell adaptation to insuli ...... nondiabetic Zucker fatty rats.
@en
P2093
Jack L Leahy
Thomas L Jetton
P2860
P304
39163-39168
P356
10.1074/JBC.M207157200
P407
P577
2002-07-29T00:00:00Z