GABA(A) receptor M2-M3 loop secondary structure and changes in accessibility during channel gating.
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Structural States and Dynamics of the D-Loop in ActinOpen-channel structures of the human glycine receptor α1 full-length transmembrane domain.Preventing voltage-dependent gating of anthrax toxin channels using engineered disulfides.Role of charged residues in coupling ligand binding and channel activation in the extracellular domain of the glycine receptor.Mechanisms of channel gating of the ligand-gated ion channel superfamily inferred from protein structure.A gating mechanism proposed from a simulation of a human alpha7 nicotinic acetylcholine receptorTransmembrane segment 11 appears to line the purine permeation pathway of the Plasmodium falciparum equilibrative nucleoside transporter 1 (PfENT1).Molecular targets and mechanisms for ethanol action in glycine receptorsHomology model of the GABAA receptor examined using Brownian dynamicsOuter pore topology of the ECaC-TRPV5 channel by cysteine scan mutagenesis.Ligand- and subunit-specific conformational changes in the ligand-binding domain and the TM2-TM3 linker of {alpha}1 {beta}2 {gamma}2 GABAA receptorsCis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel.Structure of the M2 transmembrane segment of GLIC, a prokaryotic Cys loop receptor homologue from Gloeobacter violaceus, probed by substituted cysteine accessibility.Salicylidene salicylhydrazide, a selective inhibitor of beta 1-containing GABAA receptors.5-HT3 receptor ion size selectivity is a property of the transmembrane channel, not the cytoplasmic vestibule portals.Nanosecond-timescale conformational dynamics of the human alpha7 nicotinic acetylcholine receptor.Deleterious Rare Variants Reveal Risk for Loss of GABAA Receptor Function in Patients with Genetic Epilepsy and in the General Population.Gating-induced conformational rearrangement of the γ-aminobutyric acid type A receptor β-α subunit interface in the membrane-spanning domainThe location of a closed channel gate in the GABAA receptor channel.Dynamic structural investigations on the torpedo nicotinic acetylcholine receptor by time-resolved photoaffinity labeling.Single-channel SCAM identifies pore-lining residues in the first extracellular loop and first transmembrane domains of Cx46 hemichannelsModulating inhibitory ligand-gated ion channels.Cross-linking of sites involved with alcohol action between transmembrane segments 1 and 3 of the glycine receptor following activationProbing protein packing surrounding the residues in and flanking the nicotinic acetylcholine receptor M2M3 loop.Altered Channel Conductance States and Gating of GABAA Receptors by a Pore Mutation Linked to Dravet Syndrome.The structural basis of function in Cys-loop receptors.Synaptic neurotransmitter-gated receptorsMechanisms of anabolic androgenic steroid inhibition of mammalian epsilon-subunit-containing GABAA receptors.Role of aspartate 298 in mouse 5-HT3A receptor gating and modulation by extracellular Ca2+.Trapping of ivermectin by a pentameric ligand-gated ion channel upon open-to-closed isomerization.Structural basis for allosteric coupling at the membrane-protein interface in Gloeobacter violaceus ligand-gated ion channel (GLIC).Mutational Analysis at Intersubunit Interfaces of an Anionic Glutamate Receptor Reveals a Key Interaction Important for Channel Gating by Ivermectin.Trans-cis switching mechanisms in proline analogues and their relevance for the gating of the 5-HT3 receptor.An atypical residue in the pore of Varroa destructor GABA-activated RDL receptors affects picrotoxin block and thymol modulationA single M1 residue in the beta2 subunit alters channel gating of GABAA receptor in anesthetic modulation and direct activation.Loose protein packing around the extracellular half of the GABA(A) receptor beta1 subunit M2 channel-lining segment.Channel gating of the glycine receptor changes accessibility to residues implicated in receptor potentiation by alcohols and anesthetics.The GABAA receptor alpha 1 subunit Pro174-Asp191 segment is involved in GABA binding and channel gating.Comparison of taurine- and glycine-induced conformational changes in the M2-M3 domain of the glycine receptor.A novel hyperekplexia-causing mutation in the pre-transmembrane segment 1 of the human glycine receptor alpha1 subunit reduces membrane expression and impairs gating by agonists.
P2860
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P2860
GABA(A) receptor M2-M3 loop secondary structure and changes in accessibility during channel gating.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
GABA(A) receptor M2-M3 loop se ...... ibility during channel gating.
@en
type
label
GABA(A) receptor M2-M3 loop se ...... ibility during channel gating.
@en
prefLabel
GABA(A) receptor M2-M3 loop se ...... ibility during channel gating.
@en
P2860
P356
P1476
GABA(A) receptor M2-M3 loop se ...... sibility during channel gating
@en
P2093
Maya Chatav
P2860
P304
43002-43010
P356
10.1074/JBC.M206321200
P407
P577
2002-09-10T00:00:00Z